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1.发明授权Substituted spirocyclic piperidine derivatives as histamine-3 (H3) receptor ligands 失效取代的螺环哌啶衍生物作为组胺-3（H3）受体配体公开(公告)号：US08513232B2
公开(公告)日：2013-08-20
申请号：US12846100
申请日：2010-07-29
申请人： Edward R. Bacon , Nadine C. Becknell , Reddeppa reddy Dandu , Lisa Guise-Zawacki , Tao Guo , Chia-yu Huang , Robert L. Hudkins , Babu G. Sundar , Ming Tao , Minglang Wu , Allison L. Zulli
发明人： Edward R. Bacon , Nadine C. Becknell , Reddeppa reddy Dandu , Lisa Guise-Zawacki , Tao Guo , Chia-yu Huang , Robert L. Hudkins , Babu G. Sundar , Ming Tao , Minglang Wu , Allison L. Zulli
IPC分类号： C07D491/10 , C07D401/14 , C07D471/10 , A61K31/397 , A61K31/438 , A61K31/506 , A61P11/00 , A61P1/00 , A61P25/00 , A61P29/00
CPC分类号： C07D491/10
摘要： The present invention provides compounds of Formula (I): their use as H3 antagonists/inverse agonists, processes for their preparation, and pharmaceuticals compositions thereof.
摘要翻译： 本发明提供式（I）化合物：其用作H3拮抗剂/反向激动剂，其制备方法及其药物组合物。
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2.发明申请Substituted Spirocyclic Piperidine Derivatives as Histamine-3 (H3) Receptor Ligands 失效取代的螺环哌啶衍生物作为组胺-3（H3）受体配体公开(公告)号：US20110071131A1
公开(公告)日：2011-03-24
申请号：US12846100
申请日：2010-07-29
申请人： Edward R. Bacon , Nadine C. Becknell , Reddeppa reddy Dandu , Lisa Guise-Zawacki , Tao Guo , Chia-yu Huang , Robert L. Hudkins , Babu G. Sundar , Ming Tao , Minglang Wu , Allison L. Zulli
发明人： Edward R. Bacon , Nadine C. Becknell , Reddeppa reddy Dandu , Lisa Guise-Zawacki , Tao Guo , Chia-yu Huang , Robert L. Hudkins , Babu G. Sundar , Ming Tao , Minglang Wu , Allison L. Zulli
IPC分类号： A61K31/397 , C07D471/10 , A61K31/438 , C07D413/14 , A61K31/5377 , C07D401/14 , A61K31/506 , A61P25/00 , A61P1/00 , A61P11/00 , A61P9/00 , A61P29/00
CPC分类号： C07D491/10
摘要： The present invention provides compounds of Formula (I): their use as H3 antagonists/inverse agonists, processes for their preparation, and pharmaceuticals compositions thereof.
摘要翻译： 本发明提供式（I）化合物：其用作H3拮抗剂/反向激动剂，其制备方法及其药物组合物。
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3.发明申请Substituted Pyridazinone Derivatives as Histamine-3 (H3) Receptor Ligands 审中-公开作为组胺-3（H3）受体配体的取代哒嗪酮衍生物公开(公告)号：US20110098269A1
公开(公告)日：2011-04-28
申请号：US12948496
申请日：2010-11-17
申请人： Nadine C. Becknell , Reddeppa reddy Dandu , Derek D. Dunn , Robert L. Hudkins , Kurt A. Josef , Babu G. Sundar , Allison L. Zulli
发明人： Nadine C. Becknell , Reddeppa reddy Dandu , Derek D. Dunn , Robert L. Hudkins , Kurt A. Josef , Babu G. Sundar , Allison L. Zulli
IPC分类号： A61K31/501 , C07D403/10 , C07D401/14 , C07D403/14 , C07D237/14 , C07D401/10 , C07D413/10 , A61K31/55 , A61K31/4985 , A61K31/5377 , A61P3/00 , A61P3/04 , A61P25/00 , A61P25/20 , A61P25/28 , A61P25/18 , A61P25/22 , A61P25/06 , A61P25/04 , A61P25/24 , A61P25/08 , A61P29/00 , A61P9/10 , A61P1/00 , A61P11/00
CPC分类号： C07D403/04 , C07D237/14 , C07D401/14 , C07D403/10 , C07D403/12 , C07D487/04
摘要： The present invention provides compounds according to Formulas I, II, III, IV, V, VI, VII or VIII: their use as H3 antagonists/inverse agonists, processes for their preparation, and pharmaceutical compositions thereof.
摘要翻译： 本发明提供了根据式I，II，III，IV，V，VI，VII或VIII的化合物：它们用作H3拮抗剂/反向激动剂，其制备方法及其药物组合物。
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4.发明授权Substituted phenoxypropylcycloamine derivatives as histamine-3 (H3) receptor ligands 失效取代的苯氧基丙胺环胺衍生物作为组胺-3（H3）受体配体公开(公告)号：US08648067B2
公开(公告)日：2014-02-11
申请号：US13334311
申请日：2011-12-22
申请人： Edward R. Bacon , Thomas R. Bailey , Sankar Chatterjee , Derek D. Dunn , Greg A. Hostetler , Robert L. Hudkins , Brigitte Lesur , Babu G. Sundar , Allison L. Zulli , Christophe Yue
发明人： Edward R. Bacon , Thomas R. Bailey , Sankar Chatterjee , Derek D. Dunn , Greg A. Hostetler , Robert L. Hudkins , Brigitte Lesur , Babu G. Sundar , Allison L. Zulli , Christophe Yue
IPC分类号： A61K31/55 , A61K31/54 , A61K31/45 , A61K31/535 , A61K31/497 , A61K31/545 , A61K31/445 , A01N43/40 , C07D223/18 , C07D279/10 , C07D413/00 , C07D403/00 , C07D401/00 , C07D217/00 , C07D211/00 , C07D405/00 , C07D295/00
CPC分类号： C07D403/12 , C07C217/54 , C07D207/06 , C07D207/08 , C07D207/10 , C07D207/27 , C07D209/44 , C07D211/14 , C07D211/22 , C07D211/38 , C07D211/46 , C07D215/02 , C07D215/06 , C07D217/04 , C07D241/08 , C07D295/108 , C07D295/185 , C07D401/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07D487/04
摘要： The present invention provides compounds of formula I: their use as H3 antagonists/inverse agonists, processes for their preparation, and pharmaceutical compositions thereof.
摘要翻译： 本发明提供式I化合物：它们用作H3拮抗剂/反向激动剂，其制备方法及其药物组合物。
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5.发明申请SUBSTITUTED PHENOXYPROPYLCYCLOAMINE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS 审中-公开作为HISTAMINE-3（H3）受体配体的取代的羟基丙烯酰胺衍生物公开(公告)号：US20140296212A1
公开(公告)日：2014-10-02
申请号：US14177046
申请日：2014-02-10
申请人： Edward R. Bacon , Thomas R. Bailey , Sankar Chatterjee , Derek Dunn , Greg A. Hostetler , Robert L. Hudkins , Allison L. Zulli , Brigitte Lesur , Babu G. Sundar , Christophe Yue
发明人： Edward R. Bacon , Thomas R. Bailey , Sankar Chatterjee , Derek Dunn , Greg A. Hostetler , Robert L. Hudkins , Allison L. Zulli , Brigitte Lesur , Babu G. Sundar , Christophe Yue
IPC分类号： C07D403/12 , C07C217/54 , C07D211/22 , C07D209/44 , C07D215/02 , C07D207/08 , C07D217/04
CPC分类号： C07D403/12 , C07C217/54 , C07D207/06 , C07D207/08 , C07D207/10 , C07D207/27 , C07D209/44 , C07D211/14 , C07D211/22 , C07D211/38 , C07D211/46 , C07D215/02 , C07D215/06 , C07D217/04 , C07D241/08 , C07D295/108 , C07D295/185 , C07D401/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07D487/04
摘要： The present invention provides compounds of formula I: their use as H3 antagonists/inverse agonists, processes for their preparation, and pharmaceutical compositions thereof.
摘要翻译： 本发明提供式I化合物：它们用作H3拮抗剂/反向激动剂，其制备方法及其药物组合物。
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公开(公告)号：US08524713B2
公开(公告)日：2013-09-03
申请号：US12846108
申请日：2010-07-29
IPC分类号： A01N43/58 , A61K31/50 , C07D237/00 , C07D331/02
CPC分类号： C07D491/113 , C07D491/10 , C07D491/107
摘要： The present invention provides compounds of Formula (I): their use as H3 antagonists/inverse agonists, processes for their preparation, and pharmaceuticals compositions thereof.
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7.发明申请Substituted Spirocyclic Piperidine Derivatives as Histamine-3 (H3) Receptor Ligands 有权取代的螺环哌啶衍生物作为组胺-3（H3）受体配体公开(公告)号：US20100298332A1
公开(公告)日：2010-11-25
申请号：US12846108
申请日：2010-07-29
IPC分类号： A61K31/502 , C07D237/26 , A61K31/501 , A61P3/04 , A61P25/28 , A61P25/06 , A61P25/00 , A61P25/18 , A61P25/24 , A61P25/08 , A61P1/00 , A61P29/00 , A61P11/00 , A61P9/10
CPC分类号： C07D491/113 , C07D491/10 , C07D491/107
摘要： The present invention provides compounds of Formula (I): their use as H3 antagonists/inverse agonists, processes for their preparation, and pharmaceuticals compositions thereof.
摘要翻译： 本发明提供式（I）化合物：其用作H3拮抗剂/反向激动剂，其制备方法及其药物组合物。
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8.发明申请Substituted Phenoxypropylcycloamine Derivatives as Histamine-3 (H3) Receptor Ligands 失效作为组胺-3（H3）受体配体的取代苯氧基丙基环胺衍生物公开(公告)号：US20120238551A1
公开(公告)日：2012-09-20
申请号：US13334311
申请日：2011-12-22
申请人： Edward R. Bacon , Thomas R. Bailey , Sankar Chatterjee , Derek D. Dunn , Greg A. Hostetler , Robert L. Hudkins , Brigitte Lesur , Babu G. Sundar , Allizon L. Zulli , Christophe Yue
发明人： Edward R. Bacon , Thomas R. Bailey , Sankar Chatterjee , Derek D. Dunn , Greg A. Hostetler , Robert L. Hudkins , Brigitte Lesur , Babu G. Sundar , Allizon L. Zulli , Christophe Yue
IPC分类号： A61K31/5377 , C07D403/12 , A61K31/496 , C07D401/12 , A61K31/4545 , A61K31/4025 , A61K31/4725 , A61K31/454 , A61K31/541 , C07D487/04 , A61K31/55 , A61K31/506 , A61P25/28 , A61P25/18 , A61P29/00 , A61P25/06 , A61P9/10 , A61P11/00 , A61P25/08 , A61P25/24 , A61P25/22 , A61P3/04 , A61P25/00 , C07D413/12
CPC分类号： C07D403/12 , C07C217/54 , C07D207/06 , C07D207/08 , C07D207/10 , C07D207/27 , C07D209/44 , C07D211/14 , C07D211/22 , C07D211/38 , C07D211/46 , C07D215/02 , C07D215/06 , C07D217/04 , C07D241/08 , C07D295/108 , C07D295/185 , C07D401/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07D487/04
摘要： The present invention provides compounds of formula I: their use as H3 antagonists/inverse agonists, processes for their preparation, and pharmaceutical compositions thereof.
摘要翻译： 本发明提供式I化合物：它们用作H3拮抗剂/反向激动剂，其制备方法及其药物组合物。
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公开(公告)号：US20120004231A1
公开(公告)日：2012-01-05
申请号：US13231293
申请日：2011-09-13
申请人： Robert L. Hudkins , Lars J.S. Knutsen , Catherine P. Prouty , Babu G. Sundar , Kevin J. Wells-Knecht
发明人： Robert L. Hudkins , Lars J.S. Knutsen , Catherine P. Prouty , Babu G. Sundar , Kevin J. Wells-Knecht
IPC分类号： A61K31/501 , A61P25/28 , A61P25/00 , A61P3/00 , A61K31/5377 , A61K31/502
CPC分类号： C07D237/12 , C07D237/08 , C07D237/14 , C07D237/18 , C07D237/20 , C07D401/12 , C07D403/04 , C07D405/04 , C07D409/04
摘要： The present invention is directed to compounds having histamine H3 antagonist activity, as well as methods of their use and preparation.
摘要翻译： 本发明涉及具有组胺H3拮抗剂活性的化合物及其使用和制备方法。
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公开(公告)号：US20100311752A1
公开(公告)日：2010-12-09
申请号：US12846112
申请日：2010-07-29
申请人： Robert L. Hudkins , Lars J.S. Knutsen , Catherine P. Prouty , Babu G. Sundar , Kevin J. Wells-Knecht
发明人： Robert L. Hudkins , Lars J.S. Knutsen , Catherine P. Prouty , Babu G. Sundar , Kevin J. Wells-Knecht
IPC分类号： A61K31/5377 , C07D403/12 , A61K31/501 , C07D413/14 , A61P25/28 , A61P25/18 , A61P25/24 , A61P9/10 , A61P3/04 , A61P25/06 , A61P11/00 , A61P29/00 , A61P25/20 , A61P25/00
CPC分类号： C07D237/12 , C07D237/08 , C07D237/14 , C07D237/18 , C07D237/20 , C07D401/12 , C07D403/04 , C07D405/04 , C07D409/04
摘要： The present invention is directed to compounds having histamine H3 antagonist activity, as well as methods of their use and preparation.
摘要翻译： 本发明涉及具有组胺H3拮抗剂活性的化合物及其使用和制备方法。
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