公开(公告)号：US07186416B2

公开(公告)日：2007-03-06

申请号：US10445487

申请日：2003-05-28

申请人： Karl F. Popp ,  Edward R. Yuhas

发明人： Karl F. Popp ,  Edward R. Yuhas

IPC分类号： A61K7/00 ,  A61K9/12 ,  A61K31/57

CPC分类号： A61K47/12 ,  A61K9/122 ,  A61K47/02 ,  A61K47/10 ,  Y10S514/861 ,  Y10S514/863

摘要： Novel compositions of matter comprising a foamable delivery system are provided. Novel methods for treating a disease, disorder, or condition using the novel compositions are further provided. Novel methods for making and delivering a foamable pharmaceutical composition are also provided. While the novel compositions and foamable drug delivery system may be utilized for administration of a wide variety of drugs to epithelial tissues, to treat a wide variety of diseases, disorders, or conditions, the inventive compositions and foamable drug delivery systems are particularly useful for the dermatological administration of corticosteroids and antifungal agents.

摘要翻译： 提供了包含可发泡递送系统的新型组合物。 进一步提供使用新型组合物治疗疾病，病症或状况的新方法。 还提供了制备和递送可发泡药物组合物的新方法。 虽然新型组合物和可发泡药物递送系统可用于将多种药物施用于上皮组织，以治疗各种各样的疾病，病症或病症，但本发明组合物和可发泡药物递送系统特别适用于 皮质类固醇和抗真菌剂的皮肤病学治疗。

公开(公告)号：US4322400A

公开(公告)日：1982-03-30

申请号：US76663

申请日：1979-09-18

申请人： Edward R. Yuhas

发明人： Edward R. Yuhas

IPC分类号： A61K8/34 ,  A61K8/36 ,  A61K31/055 ,  A61L9/01 ,  A61Q1/00 ,  A61Q13/00 ,  A61Q15/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61K7/42 ,  A61K7/021 ,  A61K7/44

CPC分类号： A61Q15/00 ,  A61K8/0229 ,  A61K8/042 ,  A61K8/345 ,  A61K8/361 ,  A61Q1/00 ,  A61Q13/00 ,  A61Q17/04 ,  A61Q19/00 ,  Y10S424/05 ,  Y10S424/10 ,  Y10S424/13

摘要： Solid, stick-type cosmetic compositions consist essentially of from about 1 to about 30 parts by weight of sodium stearate, 100 parts by weight of water and an "active" material intended to be applied to the skin. The composition also preferably contains a polyhydroxyl compound, such as a glycol or a polyglycol in an amount of from about 0.5 to about 10 weight percent. The addition of up to about 5 weight percent sodium chloride reduces the "syneresis" effect upon storing the compositions at low or high temperature, and increases the setting point of the composition. The compositions are useful as deodorant sticks, perfume sticks, sun sticks, hand lotion sticks, talc sticks, pigment sticks and insect repellant sticks.

摘要翻译： 固体，棒状化妆品组合物基本上由约1至约30重量份的硬脂酸钠，100重量份的水和旨在施用于皮肤的“活性”材料组成。 组合物还优选含有约0.5至约10重量％的多羟基化合物，例如二醇或聚乙二醇。 添加高达约5重量百分比的氯化钠降低了在低或高温下储存组合物时的“脱水收缩”作用，并增加了组合物的凝固点。 该组合物可用作除臭棒，香水棒，太阳棒，洗手液棒，滑石棒，颜料棒和驱虫棒。

公开(公告)号：US07829107B2

公开(公告)日：2010-11-09

申请号：US11595864

申请日：2006-11-13

申请人： Karl F. Popp ,  Edward R. Yuhas

发明人： Karl F. Popp ,  Edward R. Yuhas

IPC分类号： A61K7/00 ,  A61K7/48 ,  A61K9/12 ,  A61K31/57

CPC分类号： A61K47/12 ,  A61K9/122 ,  A61K47/02 ,  A61K47/10 ,  Y10S514/861 ,  Y10S514/863

摘要： Novel compositions of matter comprising a foamable delivery system are provided. Novel methods for treating a disease, disorder, or condition using the novel compositions are further provided. Novel methods for making and delivering a foamable pharmaceutical composition are also provided. While the novel compositions and foamable drug delivery system may be utilized for administration of a wide variety of drugs to epithelial tissues, to treat a wide variety of diseases, disorders, or conditions, the inventive compositions and foamable drug delivery systems are particularly useful for the dermatological administration of corticosteroids and antifungal agents.

摘要翻译： 提供了包含可发泡递送系统的新型组合物。 进一步提供使用新型组合物治疗疾病，病症或状况的新方法。 还提供了制备和递送可发泡药物组合物的新方法。 虽然新型组合物和可发泡药物递送系统可用于将多种药物施用于上皮组织，以治疗各种各样的疾病，病症或病症，但本发明组合物和可发泡药物递送系统特别适用于 皮质类固醇和抗真菌剂的皮肤病学治疗。

公开(公告)号：US4226889A

公开(公告)日：1980-10-07

申请号：US971113

申请日：1978-12-19

申请人： Edward R. Yuhas

发明人： Edward R. Yuhas

IPC分类号： A61K8/02 ,  A61K20060101 ,  A61K8/00 ,  A61K8/20 ,  A61K8/25 ,  A61K8/34 ,  A61K8/36 ,  A61K8/92 ,  A61K31/055 ,  A61L20060101 ,  A61Q1/00 ,  A61Q1/02 ,  A61Q1/10 ,  A61Q13/00 ,  A61Q15/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61K7/42 ,  A61K7/021 ,  A61K7/44

CPC分类号： A61Q15/00 ,  A61K8/0229 ,  A61K8/042 ,  A61K8/345 ,  A61K8/361 ,  A61Q1/00 ,  A61Q13/00 ,  A61Q17/04 ,  A61Q19/00 ,  Y10S424/05 ,  Y10S424/13

摘要： Solid, stick-type cosmetic compositions consist essentially of from about 1 to about 30 parts by weight of sodium stearate, 100 parts by weight of water and an "active" material intended to be applied to the skin. The composition also preferably contains a polyhydroxyl compound, such as a glycol or a polyglycol in an amount of from about 0.5 to about 10 weight percent. The compositions are useful as deodorant sticks, perfume sticks, sun sticks, hand lotion sticks, talc sticks, pigment sticks and insect repellant sticks.

摘要翻译： 固体，棒状化妆品组合物基本上由约1至约30重量份的硬脂酸钠，100重量份的水和旨在施用于皮肤的“活性”材料组成。 组合物还优选含有约0.5至约10重量％的多羟基化合物，例如二醇或聚乙二醇。 该组合物可用作除臭棒，香水棒，太阳棒，洗手液棒，滑石棒，颜料棒和驱虫棒。

公开(公告)号：US4169546A

公开(公告)日：1979-10-02

申请号：US921806

申请日：1978-07-03

申请人： Edward R. Yuhas ,  Gilbert L. Abrams

发明人： Edward R. Yuhas ,  Gilbert L. Abrams

IPC分类号： B05B11/00 ,  G01F11/02 ,  B67D5/42

CPC分类号： B05B11/3066 ,  B05B11/3001 ,  B05B11/307 ,  G01F11/021

摘要： A pump assembly for dispensing fluent material from within a container includes a tank and a piston defining therebetween a pump chamber and movable relative to each other to pump fluid from the container into and out of the pump chamber. A poppet interposed between the tank and the piston extends at one end thereof into the inlet conduit for the pump chamber and at the opposite end into the exhaust conduit. When the tank and piston are moving relative to each other to draw fluid from the container into the pump chamber, the end of the poppet extending to within the exhaust conduit engages against a valve seat defined in the exhaust conduit to close the exhaust conduit. The other end of the poppet extending to within the inlet conduit is frictionally engaged within the inlet conduit and the drag forces thus effected upon this end of the poppet operate to enhance the sealing effect of the opposite end of the poppet to close the exhaust conduit thereby permitting fluid to be drawn into the pump chamber. The minimum cross sectional area through which fluid flows from the container into the pump chamber through the inlet conduit is determined by the dimensions of the inlet conduit and the end of the poppet extending thereinto. By maintaining, during the exhaust stroke of the piston, the minimum cross sectional area of the inlet conduit substantially less than the flow area of the exhaust conduit, fluid within the chamber will tend to follow the path of least resistance and flow out of the exhaust conduit rather than back into the container despite the fact that the inlet conduit is maintained open during this exhaust stroke and despite the fact that no valve means tending to close the inlet conduit at the beginning of the exhaust stroke are provided.

摘要翻译： 用于从容器内分配流体材料的泵组件包括容器和在其间限定泵室的活塞，并且可相对于彼此移动以将流体从容器泵入和流出泵室。 插入在罐和活塞之间的提升阀在其一端处延伸到用于泵室的入口管道中，并且在相对端延伸到排气管道中。 当罐和活塞相对于彼此移动以将流体从容器吸入泵室时，延伸到排气管道内的提升阀的端部与限定在排气管道中的阀座接合以关闭排气管道。 提升阀延伸到入口管道内的另一端在入口管道内摩擦接合，并且由此在提升阀的该端部处实现的阻力作用，以提高提升阀的相对端的密封效应，从而关闭排气管道 允许流体被吸入泵室。 流体通过入口导管从容器流入泵室的最小横截面积由入口导管的尺寸和延伸到其中的提升阀的端部确定。 通过在活塞的排气冲程期间保持入口导管的最小横截面面积基本上小于排气管道的流动面积，腔室内的流体将倾向于沿着最小阻力的路径并流出排气 导管，而不是回到容器中，尽管在该排气冲程期间入口管道保持打开，并且尽管事实上提供了在排气冲程开始时趋向于关闭入口导管的阀门。