公开(公告)号：US11761045B2

公开(公告)日：2023-09-19

申请号：US17098940

申请日：2020-11-16

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Lihua Yu ,  Kian Huat Lim ,  Jacob D. Feala ,  Silvia Buonamici ,  Yoshiharu Mizui ,  Peter G. Smith ,  Ping Zhu ,  Eunice Sun Park ,  Michael W. Seiler ,  Marco Peter Fekkes

IPC: C12Q1/6886 ,  A61P35/00 ,  A61K31/4545 ,  A61K31/495 ,  A61K31/55 ,  C12Q1/02 ,  C12Q1/6806 ,  C12Q1/6841

CPC classification number: C12Q1/6886 ,  A61K31/4545 ,  A61K31/495 ,  A61K31/55 ,  A61P35/00 ,  C12Q1/025 ,  C12Q1/6806 ,  C12Q1/6841 ,  C12Q2600/106 ,  C12Q2600/158

Abstract: Splice variants associated with neomorphic SF3B1 mutations are described herein. This application also relates to methods of detecting the described splice variants, and uses for diagnosing cancer, evaluating modulators of SF3B1, and methods of treating cancer associated with mutations in SF3B1.

公开(公告)号：US20180318312A1

公开(公告)日：2018-11-08

申请号：US15755225

申请日：2016-08-30

Applicant: Lihua YU ,  Kian Huat LIM ,  Jacob D. FEALA ,  Silvia BUONAMICI ,  Yoshiharu MIZUI ,  Peter G. SMITH ,  Ping ZHU ,  Eunice Sun PARK ,  Michael W. SEILER ,  Marco Peter FEKKES ,  Eisai R&D Management Co., Ltd.

Inventor： Lihua Yu ,  Kian Huat Lim ,  Jacob D. Feala ,  Silvia Buonamici ,  Yoshiharu Mizui ,  Peter G. Smith ,  Ping Zhu ,  Eunice Sun Park ,  Michael W. Seiler ,  Marco Peter Fekkes

IPC: A61K31/55 ,  A61P35/00 ,  A61K31/4545 ,  A61K31/495 ,  C12Q1/6886 ,  C12Q1/02

CPC classification number: A61K31/55 ,  A61K31/4545 ,  A61K31/495 ,  A61P35/00 ,  C12Q1/025 ,  C12Q1/6806 ,  C12Q1/6841 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158

Abstract: Splice variants associated with neomorphic SF3B1 mutations are described herein. This application also relates to methods of detecting the described splice variants, and uses for diagnosing cancer, evaluating modulators of SF3B1, and methods of treating cancer associated with mutations in SF3B1.

公开(公告)号：US10889866B2

公开(公告)日：2021-01-12

申请号：US15755225

申请日：2016-08-30

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Lihua Yu ,  Kian Huat Lim ,  Jacob D. Feala ,  Silvia Buonamici ,  Yoshiharu Mizui ,  Peter G. Smith ,  Ping Zhu ,  Eunice Sun Park ,  Michael W. Seiler ,  Marco Peter Fekkes

IPC: C12Q1/6886 ,  A61P35/00 ,  A61K31/4545 ,  A61K31/495 ,  A61K31/55 ,  C12Q1/02 ,  C12Q1/6806 ,  C12Q1/6841

Abstract: Splice variants associated with neomorphic SF3B1 mutations are described herein. This application also relates to methods of detecting the described splice variants, and uses for diagnosing cancer, evaluating modulators of SF3B1, and methods of treating cancer associated with mutations in SF3B1.

公开(公告)号：US20210130909A1

公开(公告)日：2021-05-06

申请号：US17098940

申请日：2020-11-16

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Lihua Yu ,  Kian Huat Lim ,  Jacob D. Feala ,  Silvia Buonamici ,  Yoshiharu Mizui ,  Peter G. Smith ,  Ping Zhu ,  Eunice Sun Park ,  Michael W. Seiler ,  Marco Peter Fekkes

IPC: C12Q1/6886 ,  A61P35/00 ,  A61K31/4545 ,  A61K31/495 ,  A61K31/55 ,  C12Q1/02 ,  C12Q1/6806

Abstract: Splice variants associated with neomorphic SF3B1 mutations are described herein. This application also relates to methods of detecting the described splice variants, and uses for diagnosing cancer, evaluating modulators of SF3B1, and methods of treating cancer associated with mutations in SF3B1.