公开(公告)号：USRE46965E1

公开(公告)日：2018-07-24

申请号：US13924892

申请日：2013-06-24

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Brian Austad ,  Charles E. Chase ,  Francis G. Fang ,  Trevor Calkins ,  Bryan M. Lewis

IPC: C07D307/12 ,  C07F7/18 ,  C07D407/06 ,  C07D407/14 ,  C07D493/04 ,  C07D493/08 ,  C07D493/18 ,  C07D493/22 ,  C07D493/20 ,  C07D317/72 ,  C07H15/26 ,  C07C33/42 ,  A61K31/341 ,  C07D493/10 ,  C07D307/28 ,  C07D307/33

CPC classification number: C07F7/1804 ,  A61K31/341 ,  C07C33/423 ,  C07D307/12 ,  C07D307/28 ,  C07D307/33 ,  C07D317/72 ,  C07D407/06 ,  C07D407/14 ,  C07D493/04 ,  C07D493/08 ,  C07D493/10 ,  C07D493/18 ,  C07D493/20 ,  C07D493/22 ,  C07F7/188 ,  C07H15/26 ,  Y02P20/55

Abstract: The present invention provides macrocyclic compounds, synthesis of the same and intermediates thereto. Such compounds, and compositions thereof, are useful for treating or preventing proliferative disorders Formula (F-4).