公开(公告)号：US20200299321A1

公开(公告)日：2020-09-24

申请号：US16781352

申请日：2020-02-04

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Dae-Shik KIM ,  Frank FANG ,  Atsushi ENDO ,  Hyeong-wook CHOI ,  Ming-Hong HAO ,  Xingfeng BAO ,  Kuan-Chun HUANG

IPC: C07H21/02 ,  A61P35/02 ,  A61K31/7084 ,  C07F9/6587 ,  C07H21/00 ,  A61P31/04 ,  A61P37/04

Abstract: Provided herein are compounds useful for the treatment of cancer.

公开(公告)号：US20220071959A1

公开(公告)日：2022-03-10

申请号：US17528510

申请日：2021-11-17

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Xingfeng BAO ,  Diana ALBU ,  Mary WOODALL-JAPPE

IPC: A61K31/415 ,  A61K31/7068 ,  C07K16/28 ,  A61K39/00

Abstract: The present invention provides methods and compositions for treating cancer by administering an EP4 antagonist in combination with radiation therapy, antibody therapy and/or anti-metabolite chemotherapy.

公开(公告)号：US20210205348A1

公开(公告)日：2021-07-08

申请号：US17058817

申请日：2019-05-31

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Dae-Shik KIM ,  Frank FANG ,  Atsushi ENDO ,  Hyeong-Wook CHOI ,  Ming-Hong HAO ,  Xingfeng BAO ,  Kuan-Chun HUANG

IPC: A61K31/7084 ,  A61P35/04

Abstract: Provided herein are methods for the treatment of bladder cancer.

公开(公告)号：US20200055883A1

公开(公告)日：2020-02-20

申请号：US16486954

申请日：2018-02-16

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Dae-Shik KIM ,  Frank FANG ,  Atsushi ENDO ,  Hyeong-wook CHOI ,  Ming-Hong HAO ,  Xingfeng BAO ,  Kuan-Chun HUANG

IPC: C07F9/6587

Abstract: Provided herein are compounds useful for the treatment of cancer.

公开(公告)号：US20180237468A1

公开(公告)日：2018-08-23

申请号：US15898533

申请日：2018-02-17

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Dae-Shik KIM ,  Frank FANG ,  Atsushi ENDO ,  Hyeong-Wook CHOI ,  Ming-Hong HAO ,  Xingfeng BAO ,  Kuan-Chun HUANG

IPC: C07H21/02 ,  A61P35/02

CPC classification number: C07H21/02 ,  A61K31/7084 ,  A61P31/04 ,  A61P35/02 ,  A61P37/04 ,  C07F9/6587 ,  C07H21/00

Abstract: Provided herein are compounds useful for the treatment of cancer.

公开(公告)号：US20170182003A1

公开(公告)日：2017-06-29

申请号：US15312980

申请日：2015-05-21

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： Xingfeng BAO ,  Diana ALBU ,  Mary WOODALL-JAPPE

IPC: A61K31/415 ,  A61K39/00 ,  A61K31/7068

CPC classification number: A61K31/415 ,  A61K31/7068 ,  A61K39/00 ,  A61K2039/505 ,  A61K2300/00 ,  C07K16/2818 ,  C07K16/2827

Abstract: The present invention provides methods and compositions for treating cancer by administering an EP4 antagonist in combination with radiation therapy, antibody therapy and/or anti-metabolite chemotherapy.