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    Modulation of immunostimulatory properties of oligonucleotide-based compounds by utilizing modified immunostimulatory dinucleotides
    9.
    发明授权
    Modulation of immunostimulatory properties of oligonucleotide-based compounds by utilizing modified immunostimulatory dinucleotides 失效
    通过利用修饰的免疫刺激二核苷酸调节基于寡核苷酸的化合物的免疫刺激性质

    公开(公告)号：US08153608B2

    公开(公告)日：2012-04-10

    申请号：US12952863

    申请日：2010-11-23

    申请人： Sudhir Agrawal ,  Lakshmi Bhagat ,  Dong Yu ,  Ekambar R. Kandimalla

    发明人： Sudhir Agrawal ,  Lakshmi Bhagat ,  Dong Yu ,  Ekambar R. Kandimalla

    IPC分类号： C07H21/02 ,  C07H21/04 ,  A01N43/04 ,  A61K31/70

    CPC分类号： C12N15/117 ,  C07H21/00 ,  C07H21/02 ,  C07H21/04 ,  C12N15/111 ,  C12N2310/17 ,  C12N2310/33 ,  C12N2310/3519 ,  C12N2310/51

    摘要： The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunomers and an immunostimulatory oligonucleotides for use in methods for generating an immune response or for treating a patient in need of immunostimulation. The immunomers and an immunostimulatory oligonucleotides of the invention preferably comprise novel purines. The immunomers according to the invention further comprise at least two oligonucleotides linked at their 3′ ends, internucleoside linkages or functionalized nucleobase or sugar to a non-nucleotidic linker, at least one of the oligonucleotides being an immunomodulatory oligonucleotide and having an accessible 5′ end.

    摘要翻译： 本发明涉及在免疫治疗应用中寡核苷酸作为免疫刺激剂的治疗用途。 更具体地，本发明提供用于产生免疫应答的方法或用于治疗需要免疫刺激的患者的免疫学和免疫刺激性寡核苷酸。 本发明的免疫原和免疫刺激寡核苷酸优选包含新的嘌呤。 根据本发明的免疫反应物还包含至少两个在其3'末端连接的寡核苷酸，核苷间键或官能化核碱基或糖与非核酸连接体，至少一个寡核苷酸是免疫调节寡核苷酸并具有可接近的5'末端 。