公开(公告)号：US07094538B2

公开(公告)日：2006-08-22

申请号：US10166218

申请日：2002-06-10

申请人： Eldon R. Jupe ,  Linda F. Thompson ,  Regina Resta ,  Robert T. Dell'Orco

发明人： Eldon R. Jupe ,  Linda F. Thompson ,  Regina Resta ,  Robert T. Dell'Orco

IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/00 ,  C07H21/02 ,  C07H21/04

CPC分类号： C12Q1/683 ,  C12Q1/6886 ,  C12Q2600/156

摘要： The lifetime probability of a person developing cancer can now be determined based on an allelic variation found in the 3′UTR of the prohibitin gene. The probability is dependent on the sequence of the 3′UTR at position 729, i.e., whether there is a thymine (T) or a cytosine (C) or both at this position. Determining the sequence at the position 729 can be done by any number of standard techniques. Preferably, the sequence is determined by amplifying this region by PCR and subjecting it to an RFLP analysis.

公开(公告)号：US06355427B1

公开(公告)日：2002-03-12

申请号：US09297911

申请日：1999-05-07

申请人： Eldon R. Jupe ,  Linda F. Thompson ,  Regina Resta ,  Robert T. Dell'Orco

发明人： Eldon R. Jupe ,  Linda F. Thompson ,  Regina Resta ,  Robert T. Dell'Orco

IPC分类号： C12Q168

CPC分类号： C12Q1/6886 ,  C12Q2600/156

摘要： The lifetime probability of a woman developing breast cancer can now be determined based on an allelic variation found in the 3′UTR of the prohibitin gene. The probability is dependent on the sequence of the 3′UTR at position 729, i.e., whether there is a thymine (T) or a cytosine (C) or both at this position. Polymorphism at position 729 is also disclosed as a susceptibility indicator for hereditary breast cancer in men. Determining the sequence at the position 729 can be done by any number of standard techniques. Preferably, the sequence is determined by amplifying this region by PCR and subjecting it to an RFLP analysis.

摘要翻译： 现在可以基于在prohibitin基因的3'UTR中发现的等位基因变异来确定发生乳腺癌的女性的终生概率。 概率取决于位置729处的3'UTR的序列，即是否存在胸腺嘧啶（T）或胞嘧啶（C）或两者在该位置。 第729位的多态性也被公开为男性遗传性乳腺癌的易感性指标。 确定位置729处的序列可以通过任何数量的标准技术来完成。 优选地，通过PCR扩增该区域并对其进行RFLP分析来确定序列。

公开(公告)号：US07259251B1

公开(公告)日：2007-08-21

申请号：US08973689

申请日：1996-06-07

申请人： Robert T. Dell'Orco ,  Eldon R. Jupe ,  J. Keith McClung ,  Xiao-Tie Liu ,  Robert L. King

发明人： Robert T. Dell'Orco ,  Eldon R. Jupe ,  J. Keith McClung ,  Xiao-Tie Liu ,  Robert L. King

IPC分类号： C07H21/02 ,  C07H21/04

CPC分类号： C07K14/4703 ,  C12Q1/6886 ,  C12Q2600/156

摘要： The 3′ untranslated region of the human prohibitin gene has been isolated for use in a cancer susceptibility screen and as a therapeutic agent for the treatment of cancer.

摘要翻译： 已经分离出人类抑制蛋白基因的3'非翻译区，用于癌症易感性筛选和作为治疗癌症的治疗剂。