Stabilized Subtilisin Composition
    3.
    发明申请
    Stabilized Subtilisin Composition 有权
    稳定的枯草杆菌蛋白酶组成

    公开(公告)号:US20140336098A1

    公开(公告)日:2014-11-13

    申请号:US14129748

    申请日:2012-06-29

    IPC分类号: C11D3/386

    摘要: The conversion of a peptide aldehyde to a hydrosulfite adduct can be used to increase the aqueous solubility in the purification of the peptide aldehydes. Advantageously, this hydrosulfite adduct is itself effective as a subtilisin inhibitor and stabilizer and it can also stabilize a second enzyme if present. The hydrosulfite adduct is effective as a subtilisin inhibitor, and it maintains its inhibitory and stabilizing effect in a liquid detergent during storage. Thus, use of the hydrosulfite adduct can avoid the cost and time of converting it back to the peptide aldehyde and subsequent drying of the peptide aldehyde can be saved, and this can avoid the inconvenience of handling the peptide aldehyde in powder form or as a highly diluted aqueous solution.

    摘要翻译: 可以使用肽醛向连二亚硫酸酯加合物的转化来提高肽醛纯化中的水溶性。 有利地,该连二亚硫酸酯加合物本身作为枯草杆菌蛋白酶抑制剂和稳定剂本身是有效的,并且如果存在,它也可以稳定第二种酶。 连二亚硫酸盐加合物作为枯草杆菌蛋白酶抑制剂是有效的,并且在储存期间它在液体洗涤剂中保持其抑制和稳定作用。 因此,使用连二亚硫酸盐加合物可以避免将其转化为肽醛的成本和时间,并且可以节省随后的肽醛的干燥,并且这可以避免处理粉末形式的肽醛或高度的 稀释水溶液。

    Stabilized subtilisin composition
    4.
    发明授权
    Stabilized subtilisin composition 有权
    稳定的枯草杆菌蛋白酶组成

    公开(公告)号:US09085750B2

    公开(公告)日:2015-07-21

    申请号:US14129748

    申请日:2012-06-29

    摘要: The conversion of a peptide aldehyde to a hydrosulfite adduct can be used to increase the aqueous solubility in the purification of the peptide aldehydes. Advantageously, this hydrosulfite adduct is itself effective as a subtilisin inhibitor and stabilizer and it can also stabilize a second enzyme if present. The hydrosulfite adduct is effective as a subtilisin inhibitor, and it maintains its inhibitory and stabilizing effect in a liquid detergent during storage. Thus, use of the hydrosulfite adduct can avoid the cost and time of converting it back to the peptide aldehyde and subsequent drying of the peptide aldehyde can be saved, and this can avoid the inconvenience of handling the peptide aldehyde in powder form or as a highly diluted aqueous solution.

    摘要翻译: 可以使用肽醛向连二亚硫酸酯加合物的转化来提高肽醛纯化中的水溶性。 有利地,该连二亚硫酸酯加合物本身作为枯草杆菌蛋白酶抑制剂和稳定剂本身是有效的,并且如果存在,它也可以稳定第二种酶。 连二亚硫酸盐加合物作为枯草杆菌蛋白酶抑制剂是有效的,并且在储存期间它在液体洗涤剂中保持其抑制和稳定作用。 因此,使用连二亚硫酸盐加合物可以避免将其转化为肽醛的成本和时间,并且可以节省随后的肽醛的干燥,并且这可以避免处理粉末形式的肽醛或高度的 稀释水溶液。

    Process for preparing triazole antimycotic compounds
    6.
    发明授权
    Process for preparing triazole antimycotic compounds 失效
    制备三唑抗真菌化合物的方法

    公开(公告)号:US06194584B1

    公开(公告)日:2001-02-27

    申请号:US09555503

    申请日:2000-06-02

    IPC分类号: C07D24908

    摘要: Process for the preparation of a compound of formula (VII) wherein R1 is Cl, F or CF3; R2 is H, Cl, F or CF3; and R3 is C1-4 alkyl; characterized in that an olefin of formula (II) is epoxidized to give an oxirane of formula (III) which treated with alkyl-magnesium halide gives a triol of formula (IV) which is turned into an epoxide of formula (V), then treated with 1,2,4-triazole. The compounds (VII) are useful for preparing azole derivatives active as antifungal agent.

    摘要翻译: 制备其中R 1为Cl,F或CF 3的式(Ⅶ)化合物的方法; R2是H,Cl,F或CF3; 且R 3为C 1-4烷基; 其特征在于将式(II)的烯烃环氧化得到用烷基卤化镁处理的式(III)的环氧乙烷,得到式(Ⅳ)的三醇,将其转化为式(Ⅴ)的环氧化物,然后处理 与1,2,4-三唑。 化合物(VII)可用于制备作为抗真菌剂活性的唑衍生物。