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1.发明申请POLYMERIC MEMBRANES WITH HUMAN SKIN-LIKE PERMEABILITY PROPERTIES AND USES THEREOF 有权具有人类皮肤渗透性的聚合物膜及其用途公开(公告)号：US20110281771A1
公开(公告)日：2011-11-17
申请号：US13079511
申请日：2011-04-04
CPC分类号： B01D67/0088 , B01D67/0095 , B01D71/68 , Y10T428/249955 , Y10T428/249958 , Y10T428/31663 , Y10T428/31667
摘要： The present invention provides synthetic membranes which are suitable as a human skin substitute for the investigation of transdermal diffusion of candidate pharmaceutical and cosmetic compounds. The membranes according to the present invention exhibit human skin-like permeability properties with respect to the diffusion of a wide range of compounds having widely different physico-chemical properties.
摘要翻译： 本发明提供合适的膜，其适合作为人皮肤替代物来研究候选药物和化妆品化合物的透皮扩散。 根据本发明的膜相对于具有广泛不同的物理化学性质的广泛范围的化合物的扩散，显示人皮肤透过性。
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2.发明授权Polymeric membranes with human skin-like permeability properties and uses thereof 有权具有人皮肤渗透性的聚合物膜及其用途公开(公告)号：US08765254B2
公开(公告)日：2014-07-01
申请号：US13079511
申请日：2011-04-04
IPC分类号： B32B3/26
CPC分类号： B01D67/0088 , B01D67/0095 , B01D71/68 , Y10T428/249955 , Y10T428/249958 , Y10T428/31663 , Y10T428/31667
摘要： The present invention provides synthetic membranes which are suitable as a human skin substitute for the investigation of transdermal diffusion of candidate pharmaceutical and cosmetic compounds. The membranes according to the present invention exhibit human skin-like permeability properties with respect to the diffusion of a wide range of compounds having widely different physico-chemical properties.
摘要翻译： 本发明提供合适的膜，其适合作为人皮肤替代物来研究候选药物和化妆品化合物的透皮扩散。 根据本发明的膜相对于具有广泛不同的物理化学性质的广泛范围的化合物的扩散，显示人皮肤透过性。
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3.发明申请Hydrophilic, high protein binding, low fluorescence, western blotting membrane 有权亲水，高蛋白结合，低荧光，蛋白质印迹膜公开(公告)号：US20100044302A1
公开(公告)日：2010-02-25
申请号：US12462635
申请日：2009-08-06
申请人： Antoni Peters , Philip Goddard , John Charkoudian , Neil Soice , Dave Brewster , Anja Dedeo
发明人： Antoni Peters , Philip Goddard , John Charkoudian , Neil Soice , Dave Brewster , Anja Dedeo
CPC分类号： G01N33/54393 , B01D67/0093 , B01D2323/02 , B01D2323/30 , B01D2325/36 , Y10T436/24
摘要： Hydrophilic membrane particularly suited for blotting applications, preferably Western blotting. A pre-wet hydrophobic membrane substrate, preferably made of PVDF, is contacted with a monomer solution and subjected to a UV-initiated free radical polymerization step to render the substrate permanently hydrophilic. The resulting membrane exhibits low background fluorescence, high protein binding, excellent retention of protein sample spot morphology, and extended dynamic range (high signal-to-noise ratio, enhanced sample detectability). The membrane demonstrates comparable or higher performance in Western blotting applications than conventional nitrocellulose Western blotting membranes, particularly for protein detection at low sample concentrations, and is directly water-wettable, eliminating the need for an alcohol pre-wet step prior to use.
摘要翻译： 亲水膜特别适用于印迹应用，优选蛋白印迹法。 将优选由PVDF制成的预湿疏水膜基材与单体溶液接触并进行UV引发的自由基聚合步骤以使基材永久地亲水。 所得膜显示低背景荧光，高蛋白结合，优异的蛋白质样品斑点形态保留和扩展的动态范围（高信噪比，增强的样品检测性）。 与常规硝酸纤维素蛋白质印迹膜相比，该膜在Western印迹应用中表现出相当或更高的性能，特别是在低样品浓度下的蛋白质检测，并且是直接水可湿性的，在使用前无需使用酒精预湿步骤。
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4.发明申请Hydrophilic, High Protein Binding, Low Fluorescence, Western Blotting Membrane 有权亲水，高蛋白结合，低荧光，Western印迹膜公开(公告)号：US20110045493A1
公开(公告)日：2011-02-24
申请号：US12938813
申请日：2010-11-03
申请人： Antoni Peters , Philip Goddard , John Charkoudian , Neil Soice , Dave Brewster , Anja Dedeo
发明人： Antoni Peters , Philip Goddard , John Charkoudian , Neil Soice , Dave Brewster , Anja Dedeo
IPC分类号： G01N33/53
CPC分类号： G01N33/54393 , B01D67/0093 , B01D2323/02 , B01D2323/30 , B01D2325/36 , Y10T436/24
摘要： Hydrophilic membrane particularly suited for blotting applications, preferably Western blotting. A pre-wet hydrophobic membrane substrate, preferably made of PVDF, is contacted with a monomer solution and subjected to a UV-initiated free radical polymerization step to render the substrate permanently hydrophilic. The resulting membrane exhibits low background fluorescence, high protein binding, excellent retention of protein sample spot morphology, and extended dynamic range (high signal-to-noise ratio, enhanced sample detectability). The membrane demonstrates comparable or higher performance in Western blotting applications than conventional nitrocellulose Western blotting membranes, particularly for protein detection at low sample concentrations, and is directly water-wettable, eliminating the need for an alcohol pre-wet step prior to use.
摘要翻译： 亲水膜特别适用于印迹应用，优选蛋白印迹法。 将优选由PVDF制成的预湿疏水膜基材与单体溶液接触并进行UV引发的自由基聚合步骤以使基材永久地亲水。 所得膜显示低背景荧光，高蛋白结合，优异的蛋白质样品斑点形态保留和扩展的动态范围（高信噪比，增强的样品检测性）。 与常规硝酸纤维素蛋白质印迹膜相比，该膜在Western印迹应用中表现出相当或更高的性能，特别是在低样品浓度下的蛋白质检测，并且是直接水可湿性的，在使用前无需使用酒精预湿步骤。
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公开(公告)号：US08132676B2
公开(公告)日：2012-03-13
申请号：US12462635
申请日：2009-08-06
申请人： Antoni Peters , Philip Goddard , John Charkoudian , Neil Soice , Dave Brewster , Anja Dedeo
发明人： Antoni Peters , Philip Goddard , John Charkoudian , Neil Soice , Dave Brewster , Anja Dedeo
CPC分类号： G01N33/54393 , B01D67/0093 , B01D2323/02 , B01D2323/30 , B01D2325/36 , Y10T436/24
摘要： Hydrophilic membrane particularly suited for blotting applications, preferably Western blotting. A pre-wet hydrophobic membrane substrate, preferably made of PVDF, is contacted with a monomer solution and subjected to a UV-initiated free radical polymerization step to render the substrate permanently hydrophilic. The resulting membrane exhibits low background fluorescence, high protein binding, excellent retention of protein sample spot morphology, and extended dynamic range (high signal-to-noise ratio, enhanced sample detectability). The membrane demonstrates comparable or higher performance in Western blotting applications than conventional nitrocellulose Western blotting membranes, particularly for protein detection at low sample concentrations, and is directly water-wettable, eliminating the need for an alcohol pre-wet step prior to use.
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6.发明授权Hydrophilic, high protein binding, low fluorescence, western blotting membrane 有权亲水，高蛋白结合，低荧光，蛋白质印迹膜公开(公告)号：US08143067B2
公开(公告)日：2012-03-27
申请号：US12938813
申请日：2010-11-03
申请人： Antoni Peters , Philip Goddard , John Charkoudian , Neil Soice , Dave Brewster , Anja Dedeo
发明人： Antoni Peters , Philip Goddard , John Charkoudian , Neil Soice , Dave Brewster , Anja Dedeo
CPC分类号： G01N33/54393 , B01D67/0093 , B01D2323/02 , B01D2323/30 , B01D2325/36 , Y10T436/24
摘要： Hydrophilic membrane particularly suited for blotting applications, preferably Western blotting. A pre-wet hydrophobic membrane substrate, preferably made of PVDF, is contacted with a monomer solution and subjected to a UV-initiated free radical polymerization step to render the substrate permanently hydrophilic. The resulting membrane exhibits low background fluorescence, high protein binding, excellent retention of protein sample spot morphology, and extended dynamic range (high signal-to-noise ratio, enhanced sample detectability). The membrane demonstrates comparable or higher performance in Western blotting applications than conventional nitrocellulose Western blotting membranes, particularly for protein detection at low sample concentrations, and is directly water-wettable, eliminating the need for an alcohol pre-wet step prior to use.
摘要翻译： 亲水膜特别适用于印迹应用，优选蛋白印迹法。 将优选由PVDF制成的预湿疏水膜基材与单体溶液接触并进行UV引发的自由基聚合步骤以使基材永久地亲水。 所得膜显示低背景荧光，高蛋白结合，优异的蛋白质样品斑点形态保留和扩展的动态范围（高信噪比，增强的样品检测性）。 与常规硝酸纤维素蛋白质印迹膜相比，该膜在Western印迹应用中表现出相当或更高的性能，特别是在低样品浓度下的蛋白质检测，并且是直接水可湿性的，在使用前无需使用酒精预湿步骤。
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