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公开(公告)号：US20050101617A1
公开(公告)日：2005-05-12
申请号：US10704120
申请日：2003-11-10
申请人： Eli Wallace , George Topolov , Qian Zhao , Joseph Lyssikatos
发明人： Eli Wallace , George Topolov , Qian Zhao , Joseph Lyssikatos
IPC分类号： C07D239/94 , C07D401/12 , C07D403/12 , C07D405/04 , C07D417/14 , A61K31/517 , C07D43/02
CPC分类号： C07D401/12 , C07D239/94 , C07D403/12 , C07D405/04 , C07D417/14
摘要： Cyanoguanidine quinazoline and cyanoamidine quinazolamine derivatives that are useful in the treatment of hyperproliferative diseases are disclosed. Methods of treating hyperproliferative diseases in mammals are also disclosed.
摘要翻译： 公开了可用于治疗过度增生性疾病的氰氮基喹唑啉和氰基脒喹唑啉衍生物。 还公开了治疗哺乳动物过度增殖性疾病的方法。
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公开(公告)号：US08088766B2
公开(公告)日：2012-01-03
申请号：US12209738
申请日：2008-09-12
申请人： Eli Wallace , George Topolov , Qian Zhao , Joseph P. Lyssikatos
发明人： Eli Wallace , George Topolov , Qian Zhao , Joseph P. Lyssikatos
IPC分类号： C07D239/94 , C07D295/125 , A61K31/517 , A61K31/422 , C07D215/44 , A61K31/4706
CPC分类号： C07D401/12 , C07D239/94 , C07D403/12 , C07D405/04 , C07D417/14
摘要： Cyanoguanidine quinazoline and cyanoamidine quinazolamine derivatives that are useful in the treatment of hyperproliferative diseases are disclosed. Methods of treating hyperproliferative diseases in mammals are also disclosed.
摘要翻译： 公开了可用于治疗过度增生性疾病的氰氮基喹唑啉和氰基脒喹唑啉衍生物。 还公开了治疗哺乳动物过度增殖性疾病的方法。
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公开(公告)号：US07488823B2
公开(公告)日：2009-02-10
申请号：US10704120
申请日：2003-11-10
申请人： Eli Wallace , George Topolov , Qian Zhao , Joseph P. Lyssikatos
发明人： Eli Wallace , George Topolov , Qian Zhao , Joseph P. Lyssikatos
IPC分类号： C07D239/84 , C07D413/04 , A61K31/517 , A61K31/4706 , C07D215/44
CPC分类号： C07D401/12 , C07D239/94 , C07D403/12 , C07D405/04 , C07D417/14
摘要： Cyanoguanidine quinazoline and cyanoamidine quinazolamine derivatives that are useful in the treatment of hyperproliferative diseases are disclosed. Methods of treating hyperproliferative diseases in mammals are also disclosed.
摘要翻译： 公开了可用于治疗过度增生性疾病的氰氮基喹唑啉和氰基脒喹唑啉衍生物。 还公开了治疗哺乳动物过度增殖性疾病的方法。
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4.发明申请CYANOGUANIDINES AND CYANOAMIDINES AS ERBB2 AND EGFR INHIBITORS 有权作为ERBB2和EGFR抑制剂的CYANOGUANIDINES和CYANAMAMININES公开(公告)号：US20090012290A1
公开(公告)日：2009-01-08
申请号：US12209738
申请日：2008-09-12
申请人： Eli Wallace , George Topolov , Qian Zhao , Joseph P. Lyssikatos
发明人： Eli Wallace , George Topolov , Qian Zhao , Joseph P. Lyssikatos
IPC分类号： C07D239/94 , C07D401/12 , C07D413/14
CPC分类号： C07D401/12 , C07D239/94 , C07D403/12 , C07D405/04 , C07D417/14
摘要： Cyanoguanidine quinazoline and cyanoamidine quinazolamine derivatives that are useful in the treatment of hyperproliferative diseases are disclosed. Methods of treating hyperproliferative diseases in mammals are also disclosed.
摘要翻译： 公开了可用于治疗过度增生性疾病的氰氮基喹唑啉和氰基脒喹唑啉衍生物。 还公开了治疗哺乳动物过度增殖性疾病的方法。
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公开(公告)号：US20080194558A1
公开(公告)日：2008-08-14
申请号：US12081725
申请日：2008-04-21
IPC分类号： A61K31/5377 , C07D239/94 , C07D413/02 , C07D401/12 , A61K31/517 , A61K31/497 , A61P35/00
CPC分类号： C07D498/10 , C04B35/632 , C07D239/94 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D498/04
摘要： This invention concerns quinazoline analogs of Formula I: where an A group is bonded to at least one of the carbons at the 5, 6, 7 or 8 position of the bicyclic ring, and the ring is substituted by up to three independent R3 groups. The invention also includes methods of using these compounds as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
摘要翻译： 本发明涉及式I的喹唑啉类似物：其中A基团与双环的5,6,7或8位上的至少一个碳键合，并且该环被多达三个独立的R“ > 3个组。 本发明还包括使用这些化合物作为I型受体酪氨酸激酶抑制剂和治疗过度增殖性疾病如癌症的方法。
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公开(公告)号：US20090048279A1
公开(公告)日：2009-02-19
申请号：US12249421
申请日：2008-10-10
IPC分类号： A61K31/517 , C07D239/94 , A61P35/00 , C07D401/12
CPC分类号： C07D239/94 , C04B35/632 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/14
摘要： This invention provides quinazoline analogs of Formula I: where A is bonded to at least one of the carbons at the 5, 6, 7 or 8 position of the bicyclic ring, and the ring is substituted by up to two independent R3 groups. The invention also includes methods of using compounds of Formula I as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
摘要翻译： 本发明提供式I的喹唑啉类似物：其中A与双环的5,6,7或8位上的至少一个碳键合，并且该环被至多两个独立的R 3基团取代。 本发明还包括使用式I化合物作为I型受体酪氨酸激酶抑制剂和治疗过度增殖性疾病如癌症的方法。
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公开(公告)号：US20060247178A1
公开(公告)日：2006-11-02
申请号：US11415455
申请日：2006-05-01
申请人： Jeremy Hans , Eli Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph Lyssikatos , John Robinson , Christopher Corrette , Robert Delisle
发明人： Jeremy Hans , Eli Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph Lyssikatos , John Robinson , Christopher Corrette , Robert Delisle
IPC分类号： A61K38/05 , A61K38/04 , A61K31/53 , A61K31/501 , A61K31/506 , A61K31/4745 , A61K31/4439 , A61K31/433 , C07D417/02 , C07D285/08
CPC分类号： C07D513/04 , C07D285/12 , C07D417/04 , C07D417/14 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D497/04 , C07F9/65395
摘要： This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
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公开(公告)号：US20060100161A1
公开(公告)日：2006-05-11
申请号：US11252232
申请日：2005-10-17
申请人： Jeremy Hans , Eli Wallace , Qian Zhao , Joseph Lyssikatos , Thomas Aicher , Ellen Laird , John Robinson , Shelley Allen
发明人： Jeremy Hans , Eli Wallace , Qian Zhao , Joseph Lyssikatos , Thomas Aicher , Ellen Laird , John Robinson , Shelley Allen
IPC分类号： A61K38/04 , A61K31/675 , A61K31/496 , A61K31/4439 , A61K31/433 , A61K31/4245 , C07D417/04 , C07D413/04
CPC分类号： C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
摘要： This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
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公开(公告)号：US09676791B2
公开(公告)日：2017-06-13
申请号：US13607016
申请日：2012-09-07
IPC分类号： C07D239/94 , C07D498/10 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D498/04 , C04B35/632
CPC分类号： C07D498/10 , C04B35/632 , C07D239/94 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D498/04
摘要： This invention provides quinazoline analogs of Formula I: where A is bonded to at least one of the carbons at the 5, 6, 7 or 8 position of the bicyclic ring, and the ring is substituted by up to two independent R3 groups. The invention also includes methods of using compounds of Formula I as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
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公开(公告)号：US07777032B2
公开(公告)日：2010-08-17
申请号：US12496973
申请日：2009-07-02
IPC分类号： C07D239/00 , C07D239/70 , C07D471/00 , C07D487/00
CPC分类号： C07D498/10 , C04B35/632 , C07D239/94 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D498/04
摘要： This invention concerns quinazoline analogs of Formula I: where an A group is bonded to at least one of the carbons at the 5, 6, 7 or 8 position of the bicyclic ring, and the ring is substituted by up to three independent R3 groups. The invention also includes methods of using these compounds as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
摘要翻译： 本发明涉及式I的喹唑啉类似物：其中A基团与双环的5,6,7或8位上的至少一个碳键合，并且该环被多达三个独立的R 3基团取代。 本发明还包括使用这些化合物作为I型受体酪氨酸激酶抑制剂和治疗过度增殖性疾病如癌症的方法。
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