-
公开(公告)号：US08623895B2
公开(公告)日：2014-01-07
申请号：US13538698
申请日：2012-06-29
Applicant: Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R Laird , John Robinson , Shelley Allen
Inventor： Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R Laird , John Robinson , Shelley Allen
IPC: A61K31/433 , A61K31/4439 , C07D417/12 , C07D285/12
CPC classification number: C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
Abstract translation: 本发明涉及有丝分裂驱动蛋白抑制剂，特别是KSP，以及制备这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
-
公开(公告)号：US08580828B2
公开(公告)日：2013-11-12
申请号：US13586355
申请日：2012-08-15
Applicant: Jeremy Hans , Eli M. Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph P. Lyssikatos , John E. Robinson , Christopher P. Corrette , Robert Kirk DeLisle , Walter C. Voegtil
Inventor： Jeremy Hans , Eli M. Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph P. Lyssikatos , John E. Robinson , Christopher P. Corrette , Robert Kirk DeLisle , Walter C. Voegtil
IPC: A61K31/41 , C07D417/04
CPC classification number: C07D513/04 , C07D285/12 , C07D417/04 , C07D417/14 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D497/04 , C07F9/65395
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
-
公开(公告)号：US08575145B2
公开(公告)日：2013-11-05
申请号：US13059902
申请日：2009-08-18
Applicant: Shelley Allen , Laura L. Celeste , T. Gregg Davis , Robert Kirk DeLisle , Julie Marie Greschuk , Stefan D. Gross , Erik James Hicken , Leila J. Jackson , Nicholas C. Kallan , Joseph P. Lyssikatos , Fredrik P. Marmsater , Mark C. Munson , Jed Pheneger , Bryson Rast , John E. Robinson , Stephen T. Schlachter , George T. Topalov , A. Dale Wright , Qian Zhao
Inventor： Shelley Allen , Laura L. Celeste , T. Gregg Davis , Robert Kirk DeLisle , Julie Marie Greschuk , Stefan D. Gross , Erik James Hicken , Leila J. Jackson , Nicholas C. Kallan , Joseph P. Lyssikatos , Fredrik P. Marmsater , Mark C. Munson , Jed Pheneger , Bryson Rast , John E. Robinson , Stephen T. Schlachter , George T. Topalov , A. Dale Wright , Qian Zhao
IPC: A61K31/55 , A61K31/437 , A61K31/513 , A61K31/5377 , C07D471/04 , A61P35/00 , A61P25/00 , A61P29/00
CPC classification number: C07D471/04
Abstract: Compounds of Formula (I), in which A, B, R1, R1a, R2, R3, R4, R5, R6, and R7 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of immune cell-associated diseases and disorders, such as inflammatory and autoimmune diseases.
Abstract translation: 其中A，B，R1，R1a，R2，R3，R4，R5，R6和R7具有本说明书中给出的含义的式（I）化合物是可用于治疗免疫细胞相关的受体酪氨酸抑制剂 疾病和病症，例如炎性和自身免疫性疾病。
-
![SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS](/abs-image/US/2012/05/03/US20120108568A1/abs.jpg.150x150.jpg)
4.发明申请SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS 有权取代的吡唑并[1,5-a]吡嗪化合物作为TRK激酶抑制剂公开(公告)号：US20120108568A1
公开(公告)日：2012-05-03
申请号：US13382858
申请日：2010-07-09
Applicant: Shelley Allen , Steven Wade Andrews , Kevin Ronald Condroski , Julia Haas , Lily Huang , Yutong Jiang , Timothy Kercher , Jeongbeob Seo
Inventor： Shelley Allen , Steven Wade Andrews , Kevin Ronald Condroski , Julia Haas , Lily Huang , Yutong Jiang , Timothy Kercher , Jeongbeob Seo
IPC: A61K31/519 , A61K31/5377 , A61P33/02 , A61P35/00 , A61P29/00 , A61P25/28 , C07D487/04 , A61P25/00
CPC classification number: C07D487/04 , A61K31/519 , A61K31/5377 , C07D453/02 , C07D471/22 , C07D498/22 , C07D519/00
Abstract: Compounds of Formula (I) and salts thereof in which R1, R2, R3, R4, X, Y and n have the meanings given in the specification, are inhibitors of Trk kinases and are useful in the treatment of diseases which can be treated with a Trk kinase inhibitor such as pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.
Abstract translation: 其中R1，R2，R3，R4，X，Y和n具有本说明书中给出的含义的式（I）化合物及其盐是Trk激酶的抑制剂，可用于治疗可用 一种Trk激酶抑制剂，如疼痛，癌症，炎症，神经变性疾病和某些传染病。
-
![Imidazo[1,2-a]pyridine compounds as receptor tyrosine kinase inhibitors](/abs-image/US/2012/03/20/US08138181B2/abs.jpg.150x150.jpg)
5.发明授权Imidazo[1,2-a]pyridine compounds as receptor tyrosine kinase inhibitors 有权咪唑并[1,2-a]吡啶化合物作为受体酪氨酸激酶抑制剂公开(公告)号：US08138181B2
公开(公告)日：2012-03-20
申请号：US12593879
申请日：2008-03-27
Applicant: Shelley Allen , Julie Marie Greschuk , Nicholas C. Kallan , Fredrik P. Marmsäter , Mark C. Munson , James P. Rizzi , John E. Robinson , Stephen T. Schlachter , George T. Topalov , Qian Zhao , Joseph P. Lyssikatos
Inventor： Shelley Allen , Julie Marie Greschuk , Nicholas C. Kallan , Fredrik P. Marmsäter , Mark C. Munson , James P. Rizzi , John E. Robinson , Stephen T. Schlachter , George T. Topalov , Qian Zhao , Joseph P. Lyssikatos
IPC: A61K31/5386 , A61K31/437 , A61K31/506 , C07D471/02 , C07D401/14 , C07D498/08 , A61P35/04
CPC classification number: C07D471/04
Abstract: Compounds of Formula I: in which A, B, R1, R1a, R2, R3, R4, R5 R6, R7 and R8 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of diseases mediated by class 3 and class 5 receptor tyrosine kinases. Particular compounds of this invention have also been found to be inhibitors of Pim-1.
Abstract translation: 式I化合物：其中A，B，R 1，R 1a，R 2，R 3，R 4，R 5，R 6，R 7和R 8具有说明书中给出的含义，是受体酪氨酸抑制剂，其可用于治疗由3类和 5类受体酪氨酸激酶。 本发明的具体化合物也被发现是Pim-1的抑制剂。
-
Patent Agency Ranking
公开(公告)号：US07956073B2
公开(公告)日：2011-06-07
申请号：US12043456
申请日：2008-03-06
Applicant: Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R Laird , John Robinson , Shelley Allen
Inventor： Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R Laird , John Robinson , Shelley Allen
IPC: A61K31/433 , C07D285/12
CPC classification number: C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
Abstract translation: 本发明涉及有丝分裂驱动蛋白抑制剂，特别是KSP，以及制备这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
-
公开(公告)号：US20070067856A1
公开(公告)日：2007-03-22
申请号：US11519772
申请日：2006-09-13
Applicant: Alan George Robertson , Shelley Allen , David Dawbarn
Inventor： Alan George Robertson , Shelley Allen , David Dawbarn
IPC: A01K67/027 , A01K67/033 , C12Q1/68 , G01N33/53 , C07H21/04 , C12P21/06 , C07K14/48 , C40B30/06
CPC classification number: C07K14/70571 , A01K2217/05 , A61K38/00 , B01J2219/00689 , B01J2219/007 , C07K14/48 , C07K14/71 , C12N9/12 , C12N9/1205 , C12Q1/485 , G01N33/6893 , G01N33/74 , G01N2500/00
Abstract: This invention relates to the use of a domain of Trk as a therapeutic agent and for screening purposes and rational design of NGF mimetics.
Abstract translation: 本发明涉及Trk结构域作为治疗剂的用途，用于NGF模拟物的筛选和合理设计。
-
公开(公告)号：US20120270803A1
公开(公告)日：2012-10-25
申请号：US13538698
申请日：2012-06-29
Applicant: Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R. Laird , John Robinson , Shelley Allen
Inventor： Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R. Laird , John Robinson , Shelley Allen
IPC: A61K31/433 , A61K31/4439 , A61K38/55 , A61P35/02 , A61P35/00
CPC classification number: C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
Abstract translation: 本发明涉及有丝分裂驱动蛋白抑制剂，特别是KSP，以及制备这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
-
公开(公告)号：US20110201651A1
公开(公告)日：2011-08-18
申请号：US13093729
申请日：2011-04-25
Applicant: Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R. Laird , John Robinson , Shelley Allen
Inventor： Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R. Laird , John Robinson , Shelley Allen
IPC: A61K31/4439 , C07D417/04 , A61P29/00 , A61P37/06 , A61P19/02 , A61P1/00
CPC classification number: C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
Abstract translation: 本发明涉及有丝分裂驱动蛋白抑制剂，特别是KSP，以及制备这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
-
![Imidazo[1,2-a]Pyridine Compounds As Receptor Tyrosine Kinase Inhibitors](/abs-image/US/2011/07/28/US20110184013A1/abs.jpg.150x150.jpg)
10.发明申请Imidazo[1,2-a]Pyridine Compounds As Receptor Tyrosine Kinase Inhibitors 审中-公开咪唑并[1,2-a]吡啶化合物作为受体酪氨酸激酶抑制剂公开(公告)号：US20110184013A1
公开(公告)日：2011-07-28
申请号：US13122095
申请日：2009-09-30
Applicant: Shelley Allen , Fredrik P. Marmsäter , John E. Robinson , Stephen T. Schlachter , Joseph P. Lyssikatos
Inventor： Shelley Allen , Fredrik P. Marmsäter , John E. Robinson , Stephen T. Schlachter , Joseph P. Lyssikatos
IPC: A61K31/4709 , C07D471/04 , A61P35/00 , A61P43/00
CPC classification number: C07D487/04 , C07D471/04
Abstract: Compounds of Formula I and II: I II having the chemical names cis-6-fluoro-8-(3-fluoropiperidin-4-yloxy)-2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinoline and 6-fluoro-8-(trans-3-fluoropiperidin-4-yloxy)-2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinoline, respectively, and enantiomers and pharmaceutically acceptable salts thereof, are receptor tyrosine inhibitors useful in the treatment of diseases mediated by class 3 and class 5 receptor tyrosine kinases. The compounds of this invention have also been found to be inhibitors of Pim-1.
Abstract translation: 具有化学名称的顺式-6-氟-8-（3-氟哌啶-4-基氧基）-2-（7-（2-甲氧基乙氧基）咪唑并[1,2-a]吡啶的式I和II化合物： 吡啶-3-基）喹啉和6-氟-8-（反式-3-氟哌啶-4-基氧基）-2-（7-（2-甲氧基乙氧基）咪唑并[1,2-a]吡啶-3-基）喹啉 和对映异构体及其药学上可接受的盐是可用于治疗由3类和5类受体酪氨酸激酶介导的疾病的受体酪氨酸抑制剂。 本发明化合物也被发现是Pim-1的抑制剂。
-
-
-
-
-
-
-
-
-
Search Results
27
records
(took 0.037 seconds)
