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公开(公告)号：US20110033443A1
公开(公告)日：2011-02-10
申请号：US12851610
申请日：2010-08-06
申请人： Elizabeth Moran , Stephen Flowers
发明人： Elizabeth Moran , Stephen Flowers
IPC分类号： A61K39/395 , A61K38/00 , A61K31/7088 , A61K31/70 , A61K31/713 , A61P19/00 , C12N5/02
CPC分类号： A61K31/00 , A61K31/7088 , A61K38/00 , C12N15/1137 , C12N2310/14 , C12N2310/531
摘要： The present invention features methods for promoting the differentiation of osteoblast bone forming cells to a mineralization phenotype and increasing bone mass using inhibitors of Brahma. Subjects benefiting from such treatment may have non-union fractures, osteopenia or osteoporosis, osteosarcoma, or a bone graft or bone fusion or orthopedic and dental implants, osteolytic bone disease, skeletal defects or deficiencies or periodontal disease.
摘要翻译： 本发明的特征在于使用Brahma抑制剂促进成骨细胞骨形成细胞分化成矿化表型并增加骨量的方法。 受益于这种治疗的受试者可能具有非联合骨折，骨质减少或骨质疏松症，骨肉瘤或骨移植物或骨融合或矫形和牙科植入物，溶骨性骨病，骨骼缺陷或缺陷或牙周病。
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公开(公告)号：US08415316B2
公开(公告)日：2013-04-09
申请号：US12851610
申请日：2010-08-06
申请人： Elizabeth Moran , Stephen Flowers
发明人： Elizabeth Moran , Stephen Flowers
CPC分类号： A61K31/00 , A61K31/7088 , A61K38/00 , C12N15/1137 , C12N2310/14 , C12N2310/531
摘要： The present invention features methods for promoting the differentiation of osteoblast bone forming cells to a mineralization phenotype and increasing bone mass using inhibitors of Brahma. Subjects benefiting from such treatment may have non-union fractures, osteopenia or osteoporosis, osteosarcoma, or a bone graft or bone fusion or orthopedic and dental implants, osteolytic bone disease, skeletal defects or deficiencies or periodontal disease.
摘要翻译： 本发明的特征在于使用Brahma抑制剂促进成骨细胞骨形成细胞分化成矿化表型并增加骨量的方法。 受益于这种治疗的受试者可能具有非联合骨折，骨质减少或骨质疏松症，骨肉瘤或骨移植物或骨融合或矫形和牙科植入物，溶骨性骨病，骨骼缺陷或缺陷或牙周病。
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公开(公告)号：US20050018273A1
公开(公告)日：2005-01-27
申请号：US10711278
申请日：2004-09-07
申请人： Charles Honeyman , Elizabeth Moran , Libing Zhang , Anthony Pullen , Emily Pratt , Kimberly Houde , Matthew King , Craig Herb , Richard Paolini
发明人： Charles Honeyman , Elizabeth Moran , Libing Zhang , Anthony Pullen , Emily Pratt , Kimberly Houde , Matthew King , Craig Herb , Richard Paolini
CPC分类号： B82Y30/00 , C01P2002/88 , C01P2004/32 , C01P2004/51 , C01P2004/61 , C01P2004/62 , C01P2004/64 , C01P2004/82 , C01P2004/84 , C01P2006/10 , C01P2006/40 , C01P2006/60 , C01P2006/80 , C01P2006/90 , C09B67/0013 , C09B68/20 , C09B68/24 , C09B68/4235 , C09B68/44 , C09B68/446 , C09C1/00 , C09C1/24 , C09C1/343 , C09C3/10 , G02F1/167 , G02F2001/1678
摘要： In electrophoretic media, it is advantageous to use pigment particles having about 1 to 15 per cent by weight of a polymer chemically bonded to, or cross-linked around, the pigment particles. The polymer desirably has a branched chain structure with side chains extending from a main chain. Charged or chargeable groups can be incorporated into the polymer or can be bonded to the particles separately from the polymer. The polymer-coated particles can be prepared by first attaching a polymerizable or polymerization-initiating group to the particle and then reacting the particle with one or more polymerizable monomers or oligomers.
摘要翻译： 在电泳介质中，使用具有化学键合到颜料颗粒周围或与其交联的聚合物的约1至15重量％的颜料颗粒是有利的。 聚合物理想地具有从主链延伸的侧链的支链结构。 可以将带电或可带电的基团并入聚合物中，或者可以与聚合物分开地结合到颗粒上。 聚合物涂覆的颗粒可以通过首先将可聚合或聚合引发基团附着到颗粒上，然后使颗粒与一种或多种可聚合单体或低聚物反应来制备。
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公开(公告)号：US20070128352A1
公开(公告)日：2007-06-07
申请号：US11673269
申请日：2007-02-09
申请人： Charles Honeyman , Elizabeth Moran , Libing Zhang , Anthony Pullen , Emily Pratt , Kimberly Houde , Matthew King , Craig Herb , Richard Paolini
发明人： Charles Honeyman , Elizabeth Moran , Libing Zhang , Anthony Pullen , Emily Pratt , Kimberly Houde , Matthew King , Craig Herb , Richard Paolini
IPC分类号： B05D7/00
CPC分类号： B82Y30/00 , C01P2002/88 , C01P2004/32 , C01P2004/51 , C01P2004/61 , C01P2004/62 , C01P2004/64 , C01P2004/82 , C01P2004/84 , C01P2006/10 , C01P2006/40 , C01P2006/60 , C01P2006/80 , C01P2006/90 , C09B67/0013 , C09B68/20 , C09B68/24 , C09B68/4235 , C09B68/44 , C09B68/446 , C09C1/00 , C09C1/24 , C09C1/343 , C09C3/10 , G02F1/167 , G02F2001/1678
摘要： In electrophoretic media, it is advantageous to use pigment particles having about 1 to 15 per cent by weight of a polymer chemically bonded to, or cross-linked around, the pigment particles. The polymer desirably has a branched chain structure with side chains extending from a main chain. Charged or chargeable groups can be incorporated into the polymer or can be bonded to the particles separately from the polymer. The polymer-coated particles can be prepared by first attaching a polymerizable or polymerization-initiating group to the particle and then reacting the particle with one or more polymerizable monomers or oligomers.
摘要翻译： 在电泳介质中，使用具有化学键合到颜料颗粒周围或与其交联的聚合物的约1至15重量％的颜料颗粒是有利的。 聚合物理想地具有从主链延伸的侧链的支链结构。 可以将带电或可带电的基团并入聚合物中，或者可以与聚合物分开地结合到颗粒上。 聚合物涂覆的颗粒可以通过首先将可聚合或聚合引发基团附着到颗粒上，然后使颗粒与一种或多种可聚合单体或低聚物反应来制备。
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