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    Pyridyl/quinolinyl imidazoles
    2.
    发明授权
    Pyridyl/quinolinyl imidazoles 有权
    吡啶基/喹啉基咪唑

    公开(公告)号：US06465486B1

    公开(公告)日：2002-10-15

    申请号：US09524451

    申请日：2000-03-10

    申请人： Ellen W. Baxter ,  Robert E. Boyd ,  John R. Carson ,  Michele C. Jetter ,  Allen B. Reitz

    发明人： Ellen W. Baxter ,  Robert E. Boyd ,  John R. Carson ,  Michele C. Jetter ,  Allen B. Reitz

    IPC分类号： A61K3147

    CPC分类号： C07D401/06 ,  A61K31/47

    摘要： Certain imidazo pyridines/quinolines of the formula: where n is 0, 1, 2; X is independently selected from the group consisting of C1-4alkyl, bromine, chlorine, iodide, trifluoromethyl, C1-4alkoxy, —SO2NH2, nitro, and two adjacent X may be fused to form the moiety:  whereby a saturated, partially unsaturated or aromatic six-membered fused ring is formed; Y is independently selected from the group consisting of hydrogen, hydroxy, C1-4alkyl, C1-4alkoxy, trifluoromethyl and phenyl; and Z is independently selected from the group consisting of hydroxy, C1-4alkyl, bromine, chlorine, iodide, trifluoromethyl, C1-4alkoxy, —SO2NH2 and nitro; are &agr;2-adrenoceptor modulators which are useful in the treatment of hypertension, glaucoma, sexual dysfunction, depression, attention deficit hyperactivity disorder, Parkinsonism, the need for anesthesia, cardiac arrythmia or the need for analgesia.

    摘要翻译： 某些具有下式的咪唑并吡啶/喹啉：其中n是0,1,2; X独立地选自C 1-4烷基，溴，氯，碘，三氟甲基，C 1-4烷氧基，-SO 2 NH 2，硝基和两个相邻 X可以稠合形成部分：由此形成饱和的，部分不饱和的或芳族的六元稠环; Y独立地选自氢，羟基，C 1-4烷基，C 1-4烷氧基，三氟甲基和苯基; 和Z独立地选自羟基，C 1-4烷基，溴，氯，碘，三氟甲基，C 1-4烷氧基，-SO 2 NH 2和硝基;是可用于治疗高血压，青光眼，性功能障碍的α2-肾上腺素能受体调节剂 ，抑郁症，注意力缺陷多动障碍，帕金森综合征，麻醉需要，心脏心律失常或需要镇痛。

    ISOXAZOLINE ALPHA 1a/1d ADRENORECEPTOR ANTAGONISTS
    7.
    发明申请
    ISOXAZOLINE ALPHA 1a/1d ADRENORECEPTOR ANTAGONISTS 审中-公开
    ISOXAZOLINE ALPHA 1a / 1d ADRENORECEPTOR ANTAGONISTS

    公开(公告)号：US20080221116A1

    公开(公告)日：2008-09-11

    申请号：US11855757

    申请日：2007-09-14

    申请人： Ellen W. Baxter ,  Samuel O. Nortey ,  Allen B. Reitz

    发明人： Ellen W. Baxter ,  Samuel O. Nortey ,  Allen B. Reitz

    IPC分类号： A61K31/496 ,  C07D413/14

    CPC分类号： C07D413/14

    摘要： The present invention relates to isoxazolines useful as selective α1a/α1d adrenoreceptor antagonists for the treatment of benign prostatic hypertrophy and/or lower urinary tract symptoms as well as to pharmaceutical compositions comprising said compounds, processes to prepare these compounds, and the use of these compounds as α1a/α1d adrenoreceptor modulators in a method of treatment.

    摘要翻译： 本发明涉及可用作治疗良性前列腺肥大和/或下尿路症状的选择性α1A/α1D1肾上腺素受体拮抗剂的异恶唑，以及药物组合物 包括所述化合物，制备这些化合物的方法，以及这些化合物在治疗方法中作为α1A/α1D1肾上腺素受体调节剂的用途。