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公开(公告)号：US20070253940A1
公开(公告)日：2007-11-01
申请号：US10597559
申请日：2005-01-28
CPC分类号： A61K35/16
摘要： The present invention provides a platelet-rich plasma with high activities in an easy and economical manner. The platelet-rich plasma is obtained by aggregating and precipitating erythrocytes from collected whole blood selectively and facilitatively without employing centrifugation. For example, the plasma is obtained by the addition of a polymer having a residue of an organic phosphate compound. Specifically, the polymer having a residue of an organic phosphate compound can be added to whole blood and allowed to stand for a specific time, thereby to selectively and facilitatively aggregate and precipitate erythrocytes to give a supernatant. The supernatant contains much platelets which exist in their extremely intact state similar as in a living body and simultaneously provides a platelet-rich plasma with high activity comprising much plasma proteins such as fibrinogen and leukocytes.
摘要翻译： 本发明以容易且经济的方式提供具有高活性的富血小板血浆。 富血小板血浆是通过从收集的全血中聚集和沉淀红细胞而获得的，而不需要离心分离。 例如，通过加入具有有机磷酸酯化合物残基的聚合物来获得等离子体。 具体而言，可以将具有有机磷酸酯化合物残基的聚合物加入到全血中并放置一定时间，从而选择性地和有利地聚集和沉淀红细胞，得到上清液。 上清液含有许多血小板，其存在于其完全状态下，与生物体相似，并且同时提供富含血小板的血浆，其具有包含大量血浆蛋白如纤维蛋白原和白细胞的高活性。
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公开(公告)号：US20050170327A1
公开(公告)日：2005-08-04
申请号：US10523572
申请日：2003-08-01
CPC分类号： A61K35/16 , A61M1/02 , A61M2202/0415 , A61M2202/0427
摘要： An object of this invention is to provide platelet-rich plasma having high activity easily and at low cost. The object is achieved by a method for preparing platelet-rich plasma comprising a step of adding a water-soluble polymer compound to whole blood obtained by blood collection. For example, by adding poly-L-glutamic acid to whole blood and allowing the mixture to stand still for a definite period, it is possible to obtain platelet-rich plasma having high activity that contains blood plasma components containing much fibrinogen in addition to platelets in the supernatant and blood cell components including white blood cells. This invention also includes the platelet-rich plasma and the use thereof as well as a kit for preparing platelet-rich plasma.
摘要翻译： 本发明的目的是提供容易且成本低的高活性血小板。 该目的通过一种制备富血小板血浆的方法来实现，该方法包括向通过采血获得的全血中加入水溶性高分子化合物的步骤。 例如，通过向全血添加聚-L-谷氨酸并使混合物静置一定时间，除了血小板之外，还可以获得含有血浆成分含有大量纤维蛋白原的具有高活性的血小板富集血浆 在上清液和血细胞成分中包括白细胞。 本发明还包括富含血小板的血浆及其用途以及用于制备富血小板血浆的试剂盒。
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