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    Diamine compound having phosphorylcholine group, polymer thereof, and process for producing the polymer
    2.
    发明授权
    Diamine compound having phosphorylcholine group, polymer thereof, and process for producing the polymer 有权
    具有磷酸胆碱基团的二胺化合物，其聚合物，以及聚合物的制造方法

    公开(公告)号：US08063238B2

    公开(公告)日：2011-11-22

    申请号：US12439192

    申请日：2007-08-31

    申请人： Yu Nagase ,  Naoya Shimoyamada ,  Yasuhiko Iwasaki ,  Kazuhiko Ishihara

    发明人： Yu Nagase ,  Naoya Shimoyamada ,  Yasuhiko Iwasaki ,  Kazuhiko Ishihara

    IPC分类号： C07F9/02 ,  C08G18/70

    CPC分类号： C08G73/1046 ,  C07F9/091 ,  C08G18/10 ,  C08G18/3206 ,  C08G69/26 ,  C08G73/105 ,  C08G18/4854 ,  C08G18/3889

    摘要： Highly polymerizable diamine compounds having a phosphorylcholine group are disclosed. High-molecular weight polymers are obtained from the highly polymerizable diamine compound having a phosphorylcholine group as a monomer, and the polymers have improved mechanical strength, water resistance and heat resistance while maintaining excellent biocompatibility and processability of MPC polymers. Processes for producing the polymers are disclosed. The diamine compounds having a phosphorylcholine group are represented by Formula (I). The polymers contain at least 1 mol % of a specific structural unit with a phosphorylcholine group represented by Formula (II) and have a number average molecular weight of not less than 5,000. In the processes, the diamine compound is used as a monomer.

    摘要翻译： 公开了具有磷酸胆碱基团的高度可聚合的二胺化合物。 从具有磷酸胆碱基团的高度可聚合的二胺化合物作为单体获得高分子量聚合物，并且聚合物具有改善的机械强度，耐水性和耐热性，同时保持MPC聚合物优异的生物相容性和加工性。 公开了制备聚合物的方法。 具有磷酸胆碱基团的二胺化合物由式（I）表示。 聚合物含有至少1摩尔％的具有由式（II）表示的磷酸胆碱基团并且数均分子量不小于5,000的特定结构单元。 在该方法中，二胺化合物用作单体。

    Compound having phosphorylcholine group, polymer thereof and process for producing the same
    3.
    发明授权
    Compound having phosphorylcholine group, polymer thereof and process for producing the same 有权
    具有磷酸胆碱基的化合物，其聚合物及其制备方法

    公开(公告)号：US07378538B2

    公开(公告)日：2008-05-27

    申请号：US10518462

    申请日：2004-02-18

    申请人： Yu Nagase ,  Masataka Oku ,  Kazuhiko Ishihara ,  Yasuhiko Iwasaki

    发明人： Yu Nagase ,  Masataka Oku ,  Kazuhiko Ishihara ,  Yasuhiko Iwasaki

    IPC分类号： C07F9/02

    CPC分类号： C07F9/65742 ,  C07F9/091 ,  C08G18/3206 ,  C08G18/3889 ,  C08G18/7657 ,  C08G61/10 ,  C08G63/6924

    摘要： A compound of the invention is a specific compound having a phosphorylcholine group, and a polymer of the invention comprises at least 1 mol % of repeating units with a phosphorylcholine group and has a number-average molecular weight of 1,000 or more, the repeating units with a phosphorylcholine group being represented by the formula (II): wherein A is a bond selected from a single bond, —O—, —COO—, —OOC—, —CONH—, —NH—, —NHCO—, —NR2— and —CH2O— where R2 is an alkyl group having 1 to 6 carbon atoms; and m is an integer of 1 to 12.

    摘要翻译： 本发明的化合物是具有磷酸胆碱基团的具体化合物，本发明的聚合物含有至少1摩尔％的具有磷酸胆碱基的重复单元，数均分子量为1,000以上，重复单元与 磷酸胆碱基团由式（II）表示：其中A是选自单键，-O - ， - COO - ， - OOC - ， - CONH - ， - NH - ， - NHCO-， 其中R 2是具有1至6个碳原子的烷基;其中R 2是具有1至6个碳原子的烷基; m为1〜12的整数。

    Alarm notifying device and computer program
    4.
    发明授权
    Alarm notifying device and computer program 失效
    报警通知装置和计算机程序

    公开(公告)号：US06727813B2

    公开(公告)日：2004-04-27

    申请号：US09942613

    申请日：2001-08-31

    申请人： Yasuhiko Iwasaki ,  Ichiro Takahashi ,  Seigo Kurokawa ,  Kiyohiro Nakano ,  Manabu Fujimoto ,  Kouji Kakuta ,  Hiromitsu Kaneko

    发明人： Yasuhiko Iwasaki ,  Ichiro Takahashi ,  Seigo Kurokawa ,  Kiyohiro Nakano ,  Manabu Fujimoto ,  Kouji Kakuta ,  Hiromitsu Kaneko

    IPC分类号： H04Q130

    CPC分类号： G08B25/08

    摘要： An alarm notifying device comprises a circuit which performs communications via a communication line, a circuit which detects a signal indicative of an operating condition of a facility to be monitored, and an alarm signal sent therefrom, and a CPU. The alarm notifying device notifies an alarm to the outside when the alarm signal is detected. The alarm notifying device has the function of receiving a mail, the function of analyzing the contents of a text of the received mail, and the function of changing information lying inside the device according to the contents of the text of the received mail.

    摘要翻译： 报警通知装置包括通过通信线进行通信的电路，检测指示要监视的设施的操作状态的信号的电路和从其发送的报警信号以及CPU。 当检测到报警信号时，报警通知装置向外部通知报警。 报警通知装置具有接收邮件的功能，分析收到的邮件的文本的内容的功能，以及根据接收到的邮件的文本的内容来改变设备内部的信息的功能。

    Composition Comprising Platelet-Rich Plasma
    5.
    发明申请
    Composition Comprising Platelet-Rich Plasma 审中-公开
    组成富血小板血浆

    公开(公告)号：US20070253940A1

    公开(公告)日：2007-11-01

    申请号：US10597559

    申请日：2005-01-28

    申请人： Emi Sumida ,  Shohei Kasugai ,  Kazunari Akiyoshi ,  Yasuhiko Iwasaki

    发明人： Emi Sumida ,  Shohei Kasugai ,  Kazunari Akiyoshi ,  Yasuhiko Iwasaki

    IPC分类号： A61K35/16 ,  A61P17/00 ,  C07F9/02 ,  C12M1/00 ,  C12N5/00

    CPC分类号： A61K35/16

    摘要： The present invention provides a platelet-rich plasma with high activities in an easy and economical manner. The platelet-rich plasma is obtained by aggregating and precipitating erythrocytes from collected whole blood selectively and facilitatively without employing centrifugation. For example, the plasma is obtained by the addition of a polymer having a residue of an organic phosphate compound. Specifically, the polymer having a residue of an organic phosphate compound can be added to whole blood and allowed to stand for a specific time, thereby to selectively and facilitatively aggregate and precipitate erythrocytes to give a supernatant. The supernatant contains much platelets which exist in their extremely intact state similar as in a living body and simultaneously provides a platelet-rich plasma with high activity comprising much plasma proteins such as fibrinogen and leukocytes.

    摘要翻译： 本发明以容易且经济的方式提供具有高活性的富血小板血浆。 富血小板血浆是通过从收集的全血中聚集和沉淀红细胞而获得的，而不需要离心分离。 例如，通过加入具有有机磷酸酯化合物残基的聚合物来获得等离子体。 具体而言，可以将具有有机磷酸酯化合物残基的聚合物加入到全血中并放置一定时间，从而选择性地和有利地聚集和沉淀红细胞，得到上清液。 上清液含有许多血小板，其存在于其完全状态下，与生物体相似，并且同时提供富含血小板的血浆，其具有包含大量血浆蛋白如纤维蛋白原和白细胞的高活性。

    Method for preparing platelet-rich plasma
    6.
    发明申请
    Method for preparing platelet-rich plasma 审中-公开
    制备富血小板血浆的方法

    公开(公告)号：US20050170327A1

    公开(公告)日：2005-08-04

    申请号：US10523572

    申请日：2003-08-01

    申请人： Emi Sumida ,  Shohei Kasugai ,  Kazunari Akiyoshi ,  Yasuhiko Iwasaki

    发明人： Emi Sumida ,  Shohei Kasugai ,  Kazunari Akiyoshi ,  Yasuhiko Iwasaki

    IPC分类号： A61K35/16 ,  A61M1/02 ,  A61P17/00 ,  A61P19/08 ,  A61P25/00 ,  A61P43/00 ,  A01N1/02

    CPC分类号： A61K35/16 ,  A61M1/02 ,  A61M2202/0415 ,  A61M2202/0427

    摘要： An object of this invention is to provide platelet-rich plasma having high activity easily and at low cost. The object is achieved by a method for preparing platelet-rich plasma comprising a step of adding a water-soluble polymer compound to whole blood obtained by blood collection. For example, by adding poly-L-glutamic acid to whole blood and allowing the mixture to stand still for a definite period, it is possible to obtain platelet-rich plasma having high activity that contains blood plasma components containing much fibrinogen in addition to platelets in the supernatant and blood cell components including white blood cells. This invention also includes the platelet-rich plasma and the use thereof as well as a kit for preparing platelet-rich plasma.

    摘要翻译： 本发明的目的是提供容易且成本低的高活性血小板。 该目的通过一种制备富血小板血浆的方法来实现，该方法包括向通过采血获得的全血中加入水溶性高分子化合物的步骤。 例如，通过向全血添加聚-L-谷氨酸并使混合物静置一定时间，除了血小板之外，还可以获得含有血浆成分含有大量纤维蛋白原的具有高活性的血小板富集血浆 在上清液和血细胞成分中包括白细胞。 本发明还包括富含血小板的血浆及其用途以及用于制备富血小板血浆的试剂盒。

    Diamine Compound Having Phosphorylcholine Group, Polymer Thereof, and Process for Producing the Polymer
    8.
    发明申请
    Diamine Compound Having Phosphorylcholine Group, Polymer Thereof, and Process for Producing the Polymer 有权
    具有磷酰胆碱基团的二胺化合物，其聚合物以及聚合物的制备方法

    公开(公告)号：US20100036081A1

    公开(公告)日：2010-02-11

    申请号：US12439192

    申请日：2007-08-31

    申请人： Yu Nagase ,  Naoya Shimoyamada ,  Yasuhiko Iwasaki ,  Kazuhiko Ishihara

    发明人： Yu Nagase ,  Naoya Shimoyamada ,  Yasuhiko Iwasaki ,  Kazuhiko Ishihara

    IPC分类号： C07F9/09 ,  C08G73/00

    CPC分类号： C08G73/1046 ,  C07F9/091 ,  C08G18/10 ,  C08G18/3206 ,  C08G69/26 ,  C08G73/105 ,  C08G18/4854 ,  C08G18/3889

    摘要： Highly polymerizable diamine compounds having a phosphorylcholine group are disclosed. High-molecular weight polymers are obtained from the highly polymerizable diamine compound having a phosphorylcholine group as a monomer, and the polymers have improved mechanical strength, water resistance and heat resistance while maintaining excellent biocompatibility and processability of MPC polymers. Processes for producing the polymers are disclosed. The diamine compounds having a phosphorylcholine group are represented by Formula (I). The polymers contain at least 1 mol % of a specific structural unit with a phosphorylcholine group represented by Formula (II) and have a number average molecular weight of not less than 5,000. In the processes, the diamine compound is used as a monomer.

    摘要翻译： 公开了具有磷酸胆碱基团的高度可聚合的二胺化合物。 从具有磷酸胆碱基团的高度可聚合的二胺化合物作为单体获得高分子量聚合物，并且聚合物具有改善的机械强度，耐水性和耐热性，同时保持MPC聚合物优异的生物相容性和加工性。 公开了制备聚合物的方法。 具有磷酸胆碱基团的二胺化合物由式（I）表示。 聚合物含有至少1摩尔％的具有由式（II）表示的磷酸胆碱基团并且数均分子量不小于5,000的特定结构单元。 在该方法中，二胺化合物用作单体。

    Compound having phosphorylcholine group, polymer thereof and process for producing the same
    9.
    发明申请
    Compound having phosphorylcholine group, polymer thereof and process for producing the same 有权
    具有磷酸胆碱基的化合物，其聚合物及其制备方法

    公开(公告)号：US20060041160A1

    公开(公告)日：2006-02-23

    申请号：US10518462

    申请日：2004-02-18

    申请人： Yu Nagase ,  Masataka Oku ,  Kazuhiko Ishihara ,  Yasuhiko Iwasaki

    发明人： Yu Nagase ,  Masataka Oku ,  Kazuhiko Ishihara ,  Yasuhiko Iwasaki

    IPC分类号： C07F9/10

    CPC分类号： C07F9/65742 ,  C07F9/091 ,  C08G18/3206 ,  C08G18/3889 ,  C08G18/7657 ,  C08G61/10 ,  C08G63/6924

    摘要： A compound of the invention is a specific compound having a phosphorylcholine group, and a polymer of the invention comprises at least 1 mol % of repeating units with a phosphorylcholine group and has a number-average molecular weight of 1,000 or more, the repeating units with a phosphorylcholine group being represented by the formula (II): wherein A is a bond selected from a single bond, —O—, —COO—, —OOC—, —CONH—, —NH—, —NHCO—, —NR2— and —CH2O— where R2 is an alkyl group having 1 to 6 carbon atoms; and m is an integer of 1 to 12.

    摘要翻译： 本发明的化合物是具有磷酸胆碱基团的具体化合物，本发明的聚合物含有至少1摩尔％的具有磷酸胆碱基的重复单元，数均分子量为1,000以上，重复单元与 磷酸胆碱基团由式（II）表示：其中A是选自单键，-O - ， - COO - ， - OOC - ， - CONH - ， - NH - ， - NHCO-， 其中R 2是具有1至6个碳原子的烷基;其中R 2是具有1至6个碳原子的烷基; m为1〜12的整数。

    Alarm notifying device
    10.
    发明授权
    Alarm notifying device 失效
    报警通知装置

    公开(公告)号：US06700485B2

    公开(公告)日：2004-03-02

    申请号：US09942781

    申请日：2001-08-31

    申请人： Hiromitsu Kaneko ,  Koji Nonaka ,  Ichiro Takahashi ,  Seigo Kurokawa ,  Kiyohiro Nakano ,  Manabu Fujimoto ,  Yasuhiko Iwasaki ,  Kouji Kakuta

    发明人： Hiromitsu Kaneko ,  Koji Nonaka ,  Ichiro Takahashi ,  Seigo Kurokawa ,  Kiyohiro Nakano ,  Manabu Fujimoto ,  Yasuhiko Iwasaki ,  Kouji Kakuta

    IPC分类号： H04Q130

    CPC分类号： G08B25/10 ,  G08B1/08

    摘要： An alarm notifying device comprising apparatus for inputting an alarm signal of a facility to be monitored, apparatus for connecting to a mail server for delivering an electronic mail by way of a communication line, a memory for storing a guidance text corresponding to the contents of an alarm, and a CPU having the function of transmitting an electronic mail about the alarm. In the alarm notifying device, the CPU has the function of adding the contents of an alarm and a guidance text corresponding to the alarm contents to an electronic mail.

    摘要翻译： 一种报警通知装置，包括用于输入要监视的设备的报警信号的设备，用于连接到用于通过通信线路传送电子邮件的邮件服务器的设备;存储器，用于存储对应于要监视的设备的内容的引导文本 报警器和具有发送关于报警器的电子邮件功能的CPU。 在报警通知装置中，CPU具有向电子邮件添加与报警内容相对应的报警内容和指导文本的功能。