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    Method and apparatus for determining the homogeneity of a granulation during tableting
    3.
    发明授权
    Method and apparatus for determining the homogeneity of a granulation during tableting 有权
    在压片过程中确定造粒均匀性的方法和装置

    公开(公告)号：US07057722B2

    公开(公告)日：2006-06-06

    申请号：US10406737

    申请日：2003-04-03

    申请人： Lane Gehrlein ,  Emil Ciurczak ,  Gary Ritchie ,  Kevin C. Bynum

    发明人： Lane Gehrlein ,  Emil Ciurczak ,  Gary Ritchie ,  Kevin C. Bynum

    IPC分类号： G01J3/28 ,  B01F9/00

    CPC分类号： G01N21/85 ,  B30B11/08 ,  B30B15/304 ,  G01N21/3563 ,  G01N2021/0118 ,  G01N2021/8592

    摘要： An apparatus for detecting the homogeneity of a pharmaceutical mixture has a hopper for containing a mixture of two or more pharmaceutical components and that is situated within a production line of preparation of a pharmaceutical dosage form. A spectroscope is mounted to the hopper for measuring spectroscopic characteristics of the mixture, and a processing device that is not physically coupled to the spectroscope analyzes the spectroscopic characteristics of the mixture and derives information regarding the homogeneity of the mixture. The spectroscope wirelessly sends the spectroscopic characteristics to the processing device, which derives information regarding the homogeneity of the mixture. The wireless transmission of the spectroscopic characteristics can be done through infrared radiation or near infrared radiation, and the spectroscopic characteristics can be converted to digital signals prior to being transmitted.

    摘要翻译： 用于检测药物混合物的均匀性的装置具有用于容纳两种或更多种药物成分的混合物并且位于药物剂型的制备生产线内的料斗。 将分光镜安装到料斗上用于测量混合物的光谱特性，并且不物理耦合到分光镜的处理装置分析混合物的光谱特性并得出关于混合物的均匀性的信息。 分光镜将光谱特性无线发送到处理装置，该装置得到关于混合物的均匀性的信息。 光谱特性的无线传输可以通过红外辐射或近红外辐射进行，并且光谱特性可以在传输之前转换为数字信号。

    Spectroscopic analyzer for blender
    4.
    发明授权
    Spectroscopic analyzer for blender 有权
    搅拌机光谱分析仪

    公开(公告)号：US07075645B2

    公开(公告)日：2006-07-11

    申请号：US10426980

    申请日：2003-04-30

    申请人： Lane Gehrlein ,  Emil Ciurczak ,  Gary Ritchie

    发明人： Lane Gehrlein ,  Emil Ciurczak ,  Gary Ritchie

    IPC分类号： G01J3/28 ,  B01F9/00

    CPC分类号： B01F9/04 ,  B01F3/02 ,  B01F9/005 ,  B01F15/00207

    摘要： A blending apparatus comprises a blender including a container having a wall, the wall including a window. The container rotates about an axis of rotation. A wireless spectrometer is mounted to the container and operates through the window, in a direction that does not intersect the axis of rotation, for obtaining a set of spectroscopic data regarding the product during an operation of the blender. In addition, a method for assaying a blended product in a blender includes mounting a wireless spectrometer to the container, rotating the container about its axis of rotation so as to blend the product; operating the wireless spectrometer through a window in the container, in a direction that does not intersect the axis of rotation, to obtain spectroscopic data regarding the product during the blending, and determining a homogeneity of the product from the spectroscopic data.

    摘要翻译： 混合装置包括一个包括一个具有一个壁的容器的搅拌器，该墙壁包括一个窗户。 容器围绕旋转轴线旋转。 将无线光谱仪安装到容器上，并且在与旋转轴线不相交的方向上通过窗口操作，以在搅拌器的操作期间获得关于产品的一组光谱数据。 此外，用于在混合器中测定混合产品的方法包括将无线光谱仪安装到容器上，使容器围绕其旋转轴线旋转以便混合产品; 通过容器中的窗口沿不与旋转轴线相交的方向操作无线光谱仪，以获得关于混合期间产品的光谱数据，以及根据光谱数据确定产品的均匀性。

    Wireless blood glucose monitoring system
    5.
    发明申请
    Wireless blood glucose monitoring system 审中-公开
    无线血糖监测系统

    公开(公告)号：US20050033127A1

    公开(公告)日：2005-02-10

    申请号：US10766640

    申请日：2004-01-27

    申请人： Emil Ciurczak ,  Gary Ritchie ,  Howard Mark ,  Kevin Bynum

    发明人： Emil Ciurczak ,  Gary Ritchie ,  Howard Mark ,  Kevin Bynum

    IPC分类号： A61B5/00 ,  A61K20060101

    CPC分类号： A61B5/14532 ,  A61B5/1455 ,  A61B2560/0223

    摘要： A system for predicting blood glucose values in a patient includes a remote wireless non-invasive spectral device, the remote wireless non-invasive spectral device generating a spectral scan of a body part of the patient. Also included are a remote invasive device and a central processing device. The remote invasive device generates a constituent value for the patient, while the central processing device predicts a blood glucose value for the patient based upon the spectral scan and the constituent value.

    摘要翻译： 用于预测患者血糖值的系统包括远程无线非侵入性光谱设备，所述远程无线非侵入光谱设备产生患者身体部位的光谱扫描。 还包括远程侵入性装置和中央处理装置。 远程侵入性装置生成患者的构成值，而中央处理装置基于光谱扫描和构成值预测患者的血糖值。

    Automated system and method for spectroscopic analysis
    6.
    发明授权
    Automated system and method for spectroscopic analysis 有权
    光谱分析的自动化系统和方法

    公开(公告)号：US06549861B1

    公开(公告)日：2003-04-15

    申请号：US09636041

    申请日：2000-08-10

    申请人： Howard Mark ,  Emil Ciurczak ,  Gary Ritchie

    发明人： Howard Mark ,  Emil Ciurczak ,  Gary Ritchie

    IPC分类号： G01R2316

    CPC分类号： G01J3/28 ,  G01J3/0264 ,  G01J3/433 ,  G01J2003/2866

    摘要： An automated method for modeling spectral data is provided, wherein the spectral data generated by one of diffuse reflectance, clear transmission, or diffuse transmission. The method includes accessing a set of spectral data, the set of spectral data including, corresponding spectral data for each of a plurality of samples, the spectral data for each of the plurality of samples having associated therewith at least one constituent value, the at least one constituent value being a reference value for a target substance in the sample which is measured by a independent measurement technique. A plurality of data transforms are applied to the set of spectral data to generate, for each sample, a set of transformed and untransformed spectral data. The set of transformed and untransformed spectral data, with its associated constituent values, is divided into a calibration sub-set and a validation sub-set, and one or more of a partial least squares, a principal component regression, a neural net, or a multiple linear regression analysis is applied to the transformed and untransformed calibration data sub-sets to obtain corresponding modeling equations for predicting the amount of the target substance in a sample. The modeling equation which provides the best correlation between the spectral data in the validation sub-set and the corresponding constituent values in the validation sub-set is identified, preferably as a function of the SEE and SEP.

    摘要翻译： 提供了一种用于建模光谱数据的自动化方法，其中由漫反射，透明或漫射传输之一产生的光谱数据。 该方法包括访问一组光谱数据，该光谱数据集合包括多个样本中的每一个的对应光谱数据，多个样本中的每一个的光谱数据与其相关联，至少一个成分值，至少 一个成分值是通过独立测量技术测量的样品中的目标物质的参考值。 将多个数据变换应用于该光谱数据集合，以针对每个样本生成一组经变换和未转换的光谱数据。 具有其相关联的成分值的经转换和未转换的光谱数据的集合被分成校准子集和确认子集，以及一个或多个偏最小二乘法，主成分回归，神经网络或 将多元线性回归分析应用于转化和未转换的校准数据子集，以获得用于预测样品中目标物质的量的相应建模方程。 确定在验证子集中的光谱数据与验证子集中的相应组成值之间提供最佳相关性的建模方程，优选地作为SEE和SEP的函数。