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公开(公告)号：USD548357S1
公开(公告)日：2007-08-07
申请号：US29223343
申请日：2005-02-11
Applicant: Emilio Barbera-Guillem
Designer： Emilio Barbera-Guillem
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公开(公告)号：US20060180529A1
公开(公告)日：2006-08-17
申请号：US11056725
申请日：2005-02-11
Applicant: Emilio Barbera-Guillem
Inventor： Emilio Barbera-Guillem
CPC classification number: B01L3/50273 , B01L3/502761 , B01L2200/0684 , B01L2200/141 , B01L2200/16 , B01L2300/044 , B01L2300/0867 , B01L2300/0874 , B01L2400/0472 , B01L2400/0688 , B01L2400/0694 , C12M23/16 , C12M29/04
Abstract: A diffusion controlling bioreactor that selectively controls the molecular diffusion between fluids through a microchannel in fluid communication with a reaction reservoir. The length and cross-sectional area are selected to obtain a predetermined rate of molecular diffusion between fluids. When the fluids are liquids, flow through the microchannel is laminar and the capillary action of the microchannel and fluid is such that the fluid does not flow into the reaction reservoir unless the pressure of the fluid is increased by an external source, thereby minimizing contamination of the bioreactor. The instant invention may also utilize at least one microchannel and reagent reservoir to regulate, rather than prevent, the passage of various molecules into the bioreactor. A pressure equalizing vent operating on similar principles to the microchannel may have a structure configured to minimize the chances of fluid leakage from the bioreactor, even if the bioreactor is turned in various directions.
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公开(公告)号：US20050019486A1
公开(公告)日：2005-01-27
申请号：US10866929
申请日：2004-06-14
Applicant: Emilio Barbera-Guillem
Inventor： Emilio Barbera-Guillem
CPC classification number: C12Q1/6816 , B82Y15/00 , C12Q1/6818 , G01N33/586 , G01N33/588 , Y10T428/2989 , Y10T428/2991 , Y10T428/2993 , C12Q2563/161 , C12Q2563/107 , C12Q2523/107
Abstract: Provided are a functionalized, encapsulated fluorescent nanocrystal comprising a liposome having encapsulated therein one or more fluorescent nanocrystals; use of the functionalized, encapsulated fluorescent nanocrystals in detection systems; and a method of producing functionalized, encapsulated fluorescent nanocrystals. A method of using the functionalized encapsulated fluorescent nanocrystals having affinity molecule bound thereto comprises contacting the functionalized encapsulated fluorescent nanocrystals with a sample so that complexes are formed between the functionalized encapsulated fluorescent nanocrystals and substrate for which the affinity molecule has binding specificity, if the substrate is present; exposing the complexes in the detection system to an excitation light source, and detecting a fluorescence peak emitted from the complexes, if present.
Abstract translation: 提供了一种官能化包封的荧光纳米晶体，其包含其中封装有一种或多种荧光纳米晶体的脂质体; 在检测系统中使用官能化封装的荧光纳米晶体; 以及制备官能化包封的荧光纳米晶体的方法。 使用具有结合到其上的亲和分子的官能化包封的荧光纳米晶体的方法包括使官能化的包封的荧光纳米晶体与样品接触，使得在官能化的包封的荧光纳米晶体和亲本分子具有结合特异性的底物之间形成复合物，如果底物是 当下; 将检测系统中的复合物暴露于激发光源，并检测从复合物发射的荧光峰（如果存在）。
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公开(公告)号：US06760612B2
公开(公告)日：2004-07-06
申请号：US09940391
申请日：2001-08-27
Applicant: Emilio Barbera-Guillem
Inventor： Emilio Barbera-Guillem
IPC: A61B500
CPC classification number: C07K16/18 , G01N33/567 , G01N33/57426 , G01N33/57484
Abstract: A method is provided for detecting lymphoid tissues containing shed tumor antigen in an individual. A detector molecule, with binding specificity for shed tumor antigen, is administered to an individual, and detected in the individual is the presence of lymphoid tissue which contains shed tumor antigen, as detected by the signal emitted by the detector molecule bound to shed tumor antigen. The lymphoid tissue, detected as containing shed tumor antigen, may then be surgically removed, thereby removing B cells, shed tumor antigen, and follicular dendritic cells involved in a pro-tumor immune response that are contained in the removed lymphoid tissue.
Abstract translation: 提供了一种用于检测个体中含有脱落的肿瘤抗原的淋巴组织的方法。 向个体施用具有对流出的肿瘤抗原具有结合特异性的检测器分子，并且在个体中检测到存在包含流下的肿瘤抗原的淋巴组织，如通过结合到流出肿瘤抗原的检测器分子发射的信号所检测的那样 。 检测为含有脱落的肿瘤抗原的淋巴组织然后可以手术去除，从而去除参与去除的淋巴组织中包含的前肿瘤免疫应答的B细胞，脱落的肿瘤抗原和滤泡性树突状细胞。
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公开(公告)号：US06576155B1
公开(公告)日：2003-06-10
申请号：US09755407
申请日：2001-01-05
Applicant: Emilio Barbera-Guillem
Inventor： Emilio Barbera-Guillem
IPC: C09K1100
CPC classification number: C09D11/50 , A61K9/167 , B82Y15/00 , C09K11/02 , C09K11/025 , C09K11/0805 , G07F7/086 , Y10T428/24802 , Y10T428/253
Abstract: A fluorescent ink composition comprising functionalized fluorescent nanocrystals, an aqueous-based ink carrier comprising water or a water-based solution, and a binder. Also provided are methods of providing an image or a security mark on a substrate for subsequent identification by applying a fluorescent ink composition onto the substrate
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Patent Agency Ranking
6.发明授权Functionalized nanocrystals and their use in labeling for strand synthesis or sequence determination 有权官能化纳米晶体及其在链合成或序列测定标记中的应用公开(公告)号：US06221602B1
公开(公告)日：2001-04-24
申请号：US09436159
申请日：1999-11-09
Applicant: Emilio Barbera-Guillem , M. Bud Nelson , Stephanie L. Castro
Inventor： Emilio Barbera-Guillem , M. Bud Nelson , Stephanie L. Castro
IPC: C12P1934
CPC classification number: G01N33/588 , B82Y15/00 , G01N23/223 , G01N2223/076
Abstract: Provided are compositions comprising functionalized nanocrystal-labeled nucleobases that are produced by operably linking a nucleobase to a functionalized nanocrystal via reactive functionalities. Also provided are kits comprising a plurality of species of functionalized nanocrystal-labeled nucleobases. The functionalized nanocrystal-labeled nucleobases may be added to a strand synthesis reaction under suitable conditions to be incorporated into one or more strands synthesized in the reaction.
Abstract translation: 提供了包含功能化纳米晶体标记的核碱基的组合物，其通过可操作地通过反应性官能团将核碱基与功能化的纳米晶体连接而产生。 还提供了包含多种官能化的纳米晶体标记的核碱基的试剂盒。 官能化的纳米晶体标记的核碱基可以在合适的条件下加入到链合成反应中，以引入在反应中合成的一个或多个链中。
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公开(公告)号：US6114038A
公开(公告)日：2000-09-05
申请号：US372729
申请日：1999-08-11
Applicant: Stephanie L. Castro , Emilio Barbera-Guillem
Inventor： Stephanie L. Castro , Emilio Barbera-Guillem
CPC classification number: B82Y30/00 , B82Y10/00 , B82Y5/00 , Y10T428/2989 , Y10T428/2993
Abstract: Provided are compositions comprising water-soluble, functionalized nanocrystals. The water-soluble functionalized nanocrystals comprise quantum dots capped with a layer of a capping compound, and further comprise, by operably linking and in a successive manner, one or more additional compounds. The one or more additional compounds is comprised of at least a diaminocarboxylic acid which is operatively linked to the capping compound, and may further comprise an amino acid, an affinity ligand, or a combination thereof. Also provided are methods of using the functionalized nanocrystals having an affinity ligand to detect the presence or absence of a target substrate in a sample. The method comprises contacting the functionalized nanocrystals with the sample so that complexes are formed between the functionalized nanocrystals and substrate, if the substrate is present; exposing the complexes in the detection system to a wavelength of light suitable for exciting the functionalized nanocrystals of the complexes to emit a luminescence peak; and detecting the emitted luminescence peak.
Abstract translation: 提供了包含水溶性官能化纳米晶体的组合物。 水溶性官能化纳米晶体包括用封端化合物层覆盖的量子点，并且还通过可操作地连接并以连续的方式包含一种或多种另外的化合物。 一种或多种另外的化合物由至少一种与封端化合物有效连接的二氨基羧酸组成，并且还可包含氨基酸，亲和配体或其组合。 还提供了使用具有亲和配体的功能化纳米晶体来检测样品中目标底物的存在或不存在的方法。 该方法包括使官能化的纳米晶体与样品接触，使得如果存在底物，则在官能化的纳米晶体和衬底之间形成复合物; 将检测系统中的复合物暴露于适于激发复合物的官能化纳米晶体的光的波长以发射发光峰; 并检测发射的发光峰。
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8.发明授权Fluorescent ink compositions comprising functionalized fluorescent nanocrystals 有权包含官能化荧光纳米晶体的荧光墨水组合物公开(公告)号：US07785717B2
公开(公告)日：2010-08-31
申请号：US10884528
申请日：2004-07-02
Applicant: Emilio Barbera-Guillem
Inventor： Emilio Barbera-Guillem
CPC classification number: C09D11/50 , A61K9/167 , B82Y15/00 , C09K11/02 , C09K11/025 , C09K11/0805 , G07F7/086 , Y10T428/24802 , Y10T428/253
Abstract: A fluorescent ink composition comprising functionalized fluorescent nanocrystals, an aqueous-based ink carrier comprising water or a water-based solution, and a binder. Also provided are methods of providing an image or a security mark on a substrate for subsequent identification by applying a fluorescent ink composition onto the substrate.
Abstract translation: 包含官能化荧光纳米晶体的荧光墨水组合物，包含水或水基溶液的水基墨水载体和粘合剂。 还提供了在衬底上提供图像或安全标记以便随后通过将荧光墨水组合物施加到基底上的方法。
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9.发明申请BIOREACTOR FOR SELECTIVELY CONTROLLING THE MOLECULAR DIFFUSION BETWEEN FLUIDS 有权用于选择性地控制流体之间的分子扩散的生物反应器公开(公告)号：US20090202400A1
公开(公告)日：2009-08-13
申请号：US12389523
申请日：2009-02-20
Applicant: Emilio Barbera-Guillem
Inventor： Emilio Barbera-Guillem
IPC: B01J19/00
CPC classification number: C12M23/16 , B01L3/50273 , B01L2200/0684 , B01L2200/16 , B01L2300/0867 , B01L2400/0472 , B01L2400/086 , C12M29/04
Abstract: A diffusion controlling bioreactor that selectively controls the molecular diffusion between fluids through at least one microchannel in fluid communication with a reaction reservoir. Length and cross-sectional area of the microchannel may be selected to obtain a predetermined rate of molecular diffusion between fluids. When the fluids are liquids, flow through the microchannel is laminar and the capillary action of the microchannel and fluid is such that the fluid flow is regulated, and may have a structure configured to minimize the chances of fluid leakage from the bioreactor, even if the bioreactor is turned in various directions. In certain embodiments, one or more diffusion control chambers regulate fluid flow and diffusion between a reaction reservoir and an outside atmosphere.
Abstract translation: 扩散控制生物反应器，其选择性地控制流体之间的分子扩散通过与反应储存器流体连通的至少一个微通道。 可以选择微通道的长度和横截面面积以获得流体之间的预定分子扩散速率。 当流体是液体时，流过微通道的流动是层流的，并且微通道和流体的毛细管作用使得流体流动被调节，并且可以具有构造成使得从生物反应器泄漏的机会最小化的结构，即使 生物反应器在各个方向转动。 在某些实施例中，一个或多个扩散控制室调节反应容器和外部气氛之间的流体流动和扩散。
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10.发明申请Nanocrystals having polynucleotide strands and their use to form dendrimers in a signal amplification system 审中-公开具有多核苷酸链的纳米晶体及其在信号放大系统中形成树枝状大分子的用途公开(公告)号：US20080020937A1
公开(公告)日：2008-01-24
申请号：US10975642
申请日：2004-10-28
Applicant: Emilio Barbera-Guillem , M. Nelson , Stephanie Castro
Inventor： Emilio Barbera-Guillem , M. Nelson , Stephanie Castro
CPC classification number: B82Y5/00 , B82Y10/00 , B82Y15/00 , C12Q1/682 , G01N33/54306 , G01N33/588 , Y10T436/143333 , C12Q2563/149 , C12Q2563/131 , C12Q2563/107
Abstract: Provided are compositions and assay kits comprising functionalized nanocrystals having extending therefrom a plurality of polynucleotide strands of known sequence; wherein primary dots are used to operably link to a molecular probe, and secondary dots comprise a plurality of polynucleotide strands which are complementary to the plurality of polynucleotide strands of the primary dots. Also provided is a method for detecting the presence or absence of target molecule in a sample comprising operably linking primary dots to molecular probe, contacting the complex formed with the sample, contacting the sample with successive additions of secondary dots and primary dots. If target molecule is present in the sample, the primary dots and secondary dots will form dendrimers that can be detected by fluorescence emission.
Abstract translation: 提供了包含官能化纳米晶体的组合物和测定试剂盒，其具有从其延伸的多个已知序列的多核苷酸链; 其中主要点用于可操作地连接到分子探针，并且次要点包括与主要点的多个多核苷酸链互补的多个多核苷酸链。 还提供了用于检测样品中靶分子存在或不存在的方法，其包括可操作地将原始点与分子探针连接，使与样品形成的复合物接触，使样品与次要点和原始点的连续添加接触。 如果样品中存在靶分子，则主要点和次要点将形成可通过荧光发射检测的树枝状大分子。
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