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    Imidazol-2-carboxamide derivatives as raf kinase inhibitors
    9.
    发明授权
    Imidazol-2-carboxamide derivatives as raf kinase inhibitors 失效
    咪唑-2-甲酰胺衍生物作为raf激酶抑制剂

    公开(公告)号：US06987119B2

    公开(公告)日：2006-01-17

    申请号：US10220675

    申请日：2001-03-02

    申请人： Alessandra Gaiba ,  Andrew Kenneth Takle ,  David Matthew Wilson

    发明人： Alessandra Gaiba ,  Andrew Kenneth Takle ,  David Matthew Wilson

    IPC分类号： A61K31/44 ,  C07D401/04

    CPC分类号： C07D401/04

    摘要： Compounds of formula (I): wherein X is O, CH2, S or NH, or the moiety X—R1 is hydrogen; V is CH or N; R1 is hydrogen, C1-6alkyl, C3-7cycloalkyl, aryl, arylC1-6alkyl, heterocyclyl, heterocyclyl-C1-6alkyl, heteroaryl, or heteroarylC1-6alkyl any of which except hydrogen may be optionally substituted; R2 and R3 independently represent hydrogen, C1-6alkyl, C3-7cycloalkyl, aryl, arylC1-6alkyl, heteroaryl, heteroarylC1-6alkyl, heterocyclyl, or heterocyclylC1-6alkyl any one of which except hydrogen may be optionally substituted, or R2 and R3 together with the nitrogen atom to which they are attached form a 4- to 10-membered optionally substituted monocyclic or bicyclic ring; Ar is an aryl or heteroaryl ring either of which may be optionally substituted; one of X1 and X2 is N and the other is NR4, wherein R4 is hydrogen, C1-6alkyl, or arylC1-6alkyl; or pharmaceutically acceptable salts thereof; their use as inhibitors of Raf kinases and pharmaceutical compositions containing them.

    摘要翻译： 式（I）的化合物：其中X是O，CH 2，S或NH，或X-R 1部分是氢; V是CH或N; R 1是氢，C 1-6烷基，C 3-7环烷基，芳基，芳基C 1-6 烷基，杂环基，杂环基-C 1-6烷基，杂芳基或杂芳基C 1-6烷基，除氢以外的任何一个可以任选被取代; R 2和R 3独立地表示氢，C 1-6烷基，C 3-7环烷基，芳基 ，芳基C 1-6烷基，杂芳基，杂芳基C 1-6烷基，杂环基或杂环基C 1-6烷基，除氢以外的任何一个 可以任选地被取代，或者R 2和R 3与它们所连接的氮原子一起形成4-至10-元任选取代的单环或双环; Ar是任选被取代的芳基或杂芳基环; X 1和X 2之一是N，另一个是NR 4，其中R 4是氢， C 1-6烷基或芳基C 1-6烷基; 或其药学上可接受的盐; 它们用作Raf激酶的抑制剂和含有它们的药物组合物。