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7 条记录 (耗时 0.031 秒)

    Imidazol derivatives as Raf kinase inhibitors
    7.
    发明申请
    Imidazol derivatives as Raf kinase inhibitors 审中-公开

    公开(公告)号：US20060122207A1

    公开(公告)日：2006-06-08

    申请号：US11333003

    申请日：2006-01-17

    申请人： Jon Steadman ,  Andrew Takle

    发明人： Jon Steadman ,  Andrew Takle

    IPC分类号： A61K31/513 ,  A61K31/506 ,  C07D417/02 ,  C07D413/02

    CPC分类号： C07D401/04

    摘要： Compounds of formula (I): wherein X is O, CH2, S or NH, or the moiety X—R1 is hydrogen; V is CH or N; R1 is hydrogen, C1-6alkyl, C3-7cycloalkyl, aryl, arylC1-6alkyl, heterocyclyl, heterocyclylC1-6alkyl, heteroaryl, or heteroarylC1-6alkyl any of which except for hydrogen may be optionally substituted; R2 and R3 independently represent optionally substituted C1-6alkyl, or R2 and R3 together with the carbon atom to which they are attached form an optionally substituted C3-7cycloalkyl or C3-7cycloalkenyl ring; or R2 and R3 together with the carbon atom to which they are attached form an optionally substituted 5 to 7-membered heterocyclyl ring containing up to 3 heteroatoms selected from N, O, S.R4 and R5 independently represent hydrogen, C1-6alkyl, C3-7cycloalkyl, aryl, arylC1-6alkyl, heteroaryl, heteroarylC1-6alkyl, heterocyclyl, or heterocyclylC1-6alkyl, any of which except for hydrogen may be optionally substituted or R4 and R5 together with the nitrogen atom to which they are attached form 4- to 8-membered ring; Ar is an aryl or heteroaryl ring either of which may be optionally substituted; one of X1 and X2 is N and the other is NR6, wherein R6 is hydrogen, C1-6alkyl, or arylC1-6alkyl or pharmaceutically acceptable salts thereof, their use as inhibitors of Raf kinases, and pharmaceutical compositions containing them.