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公开(公告)号：US20060025459A1
公开(公告)日：2006-02-02
申请号：US10536303
申请日：2003-12-03
申请人： Emmanuel Demont , Andrew Faller , David Macpherson , Peter Milner , Alan Naylor , Sally Redshaw , Steven Stanway , David Vesey , Daryl Walter
发明人： Emmanuel Demont , Andrew Faller , David Macpherson , Peter Milner , Alan Naylor , Sally Redshaw , Steven Stanway , David Vesey , Daryl Walter
IPC分类号： A61K31/425 , A61K31/4025 , A61K31/4015 , C07D417/02 , C07D403/02
CPC分类号： C07D207/267 , C07D211/76 , C07D275/02 , C07D279/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The present invention relates to novel hydroxyethylamine compounds having Asp2 (β-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated β-amyloid levels or β-amyloid deposits, particularly Alzheimer's disease.
摘要翻译： 本发明涉及具有Asp2（β-分泌酶，BACE1或Memapsin）抑制活性的新型羟乙基胺化合物，其制备方法，含有它们的组合物及其用于治疗以β-淀粉样蛋白升高或β- 淀粉样沉积物，特别是阿尔茨海默氏病。
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2.发明申请Benzamide derivatives, processes for their preparation, and their pharmaceutical use 失效苯甲酰胺衍生物，其制备方法及其药物用途公开(公告)号：US20050085520A1
公开(公告)日：2005-04-21
申请号：US10496269
申请日：2002-11-29
IPC分类号： A61K31/402 , A61K31/4025 , A61K31/421 , A61K31/4439 , A61K31/451 , A61K31/55 , A61P9/00 , A61P25/16 , A61P25/28 , A61P43/00 , C07D207/26 , C07D207/267 , C07D207/27 , C07D211/76 , C07D223/10 , C07D263/20 , C07D263/22 , C07D401/04 , A61K31/426 , A61K31/4164
CPC分类号： C07D207/267 , C07D211/76 , C07D223/10 , C07D263/22
摘要： The present invention relates to novel hydroxyethylene compounds having Asp2 (β-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated β-amyloid levels or β-amyloid deposits, particularly Alzheimer's disease.
摘要翻译： 本发明涉及具有Asp2（β-分泌酶，BACE1或Memapsin）抑制活性的新型羟基亚乙基化合物，其制备方法，含有它们的组合物及其用于治疗以β-淀粉样蛋白升高或β- 淀粉样沉积物，特别是阿尔茨海默氏病。
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