公开(公告)号：US20060025459A1

公开(公告)日：2006-02-02

申请号：US10536303

申请日：2003-12-03

Applicant: Emmanuel Demont ,  Andrew Faller ,  David Macpherson ,  Peter Milner ,  Alan Naylor ,  Sally Redshaw ,  Steven Stanway ,  David Vesey ,  Daryl Walter

Inventor： Emmanuel Demont ,  Andrew Faller ,  David Macpherson ,  Peter Milner ,  Alan Naylor ,  Sally Redshaw ,  Steven Stanway ,  David Vesey ,  Daryl Walter

IPC: A61K31/425 ,  A61K31/4025 ,  A61K31/4015 ,  C07D417/02 ,  C07D403/02

CPC classification number: C07D207/267 ,  C07D211/76 ,  C07D275/02 ,  C07D279/02 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12

Abstract: The present invention relates to novel hydroxyethylamine compounds having Asp2 (β-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated β-amyloid levels or β-amyloid deposits, particularly Alzheimer's disease.

Abstract translation: 本发明涉及具有Asp2（β-分泌酶，BACE1或Memapsin）抑制活性的新型羟乙基胺化合物，其制备方法，含有它们的组合物及其用于治疗以β-淀粉样蛋白升高或β- 淀粉样沉积物，特别是阿尔茨海默氏病。

公开(公告)号：US20080058391A1

公开(公告)日：2008-03-06

申请号：US11835522

申请日：2007-08-08

Applicant: Christopher Johnson ,  David MacPherson ,  Giancarlo Trani

Inventor： Christopher Johnson ,  David MacPherson ,  Giancarlo Trani

IPC: A61K31/44 ,  A61P1/00 ,  A61P25/00 ,  C07D213/02

CPC classification number: C07D213/38

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein; each of R1 to R4 is independently selected from hydrogen and C1-4 alkyl and each of rings A and B independently is optionally further substituted by up to three substituents, each of which is independently selected from the group consisting of halogen, hydroxy, C1-4alkoxy, C1-4alkyl, C1-5alkanoyl, CF3, CF3O and cyano; with the proviso that ring A must contain at least one CF3 group, are useful in the treatment of diseases and conditions mediated by modulation of use-dependent voltage-gated sodium channels.

Abstract translation: 式（I）化合物及其药学上可接受的盐：其中; R 1至R 4中的每一个独立地选自氢和C 1-4 - 烷基，环A和B各自独立地任选地进一步 被至多三个取代基取代，每个取代基独立地选自卤素，羟基，C 1-4烷氧基，C 1-4烷基，C 1-4烷基， 烷基，CF 3，CF 3 O和氰基; 条件是环A必须含有至少一个CF 3 3基团，可用于治疗由依赖于用途的电压门控钠通道调节介导的疾病和病症。

公开(公告)号：US20130312589A1

公开(公告)日：2013-11-28

申请号：US13478671

申请日：2012-05-23

Applicant: Luke David MacPherson

Inventor： Luke David MacPherson

IPC: G10H7/00

CPC classification number: G10H1/0008 ,  G10H1/42 ,  G10H1/46 ,  G10H2210/391 ,  G10H2220/371 ,  G10H2240/131

Abstract: Methods, devices, systems, and computer programs are presented for providing music while exercising. One method includes an operation for receiving a request for a music segment from a computing device. The request includes the pace of exercise of a user associated with the computing device. The music segment is selected based on the pace, and the music segment is modified to correlate the tempo of the music segment to the pace of exercise. The modified music segment is sent to the computing device to be played in one or more speakers to provide music that is correlated to the exercise.

Abstract translation: 呈现方法，设备，系统和计算机程序，用于在运动时提供音乐。 一种方法包括从计算设备接收对音乐段的请求的操作。 该请求包括与计算设备相关联的用户的锻炼速度。 根据节奏选择音乐片段，修改音乐片段以将音乐片段的节奏与运动速度相关联。 经修改的音乐段被发送到计算设备以在一个或多个扬声器中播放以提供与该练习相关的音乐。

公开(公告)号：US08311741B1

公开(公告)日：2012-11-13

申请号：US13289299

申请日：2011-11-04

Applicant: Michael Jan Lawther ,  Luke David Macpherson ,  Andrew Foster

Inventor： Michael Jan Lawther ,  Luke David Macpherson ,  Andrew Foster

IPC: H04B10/00

CPC classification number: G08G1/096811 ,  G01C21/3461 ,  G08G1/096838 ,  G08G1/096866 ,  H04W4/02 ,  H04W4/027 ,  H04W4/029

Abstract: Methods and systems for providing routing information to a user are disclosed. Based on a request for routing information between an origin and destination for a travel objective, wireless coverage data for the geographic area associated with the travel objective is received. A graph model for determining routes between the origin and destination is adjusted based at least in part on the wireless coverage data. According to particular aspects of the present disclosure, the graph model can be adjusted based on the wireless coverage data and at least additional parameter such as estimated trip time, average speed, distance, favored routes or traffic information. User information can be optionally provided and used to emphasize or deemphasize wireless coverage data in the determination of the route for the travel objective.

Abstract translation: 公开了向用户提供路由信息的方法和系统。 基于对旅行目的地的起点和目的地之间路由信息的请求，接收与旅行目的相关联的地理区域的无线覆盖数据。 至少部分地基于无线覆盖数据来调整用于确定起点和目的地之间的路线的图形模型。 根据本公开的特定方面，可以基于无线覆盖数据和至少另外的参数（例如估计的跳闸时间，平均速度，距离，有利路线或交通信息）来调整图形模型。 可以可选地提供用户信息并用于在确定旅行目标的路线时强调或去强调无线覆盖数据。

公开(公告)号：US20050085520A1

公开(公告)日：2005-04-21

申请号：US10496269

申请日：2002-11-29

Applicant: Andrew Faller ,  David Macpherson ,  Peter Milner ,  Steven Stanway ,  Leontine Trouw

Inventor： Andrew Faller ,  David Macpherson ,  Peter Milner ,  Steven Stanway ,  Leontine Trouw

IPC: A61K31/402 ,  A61K31/4025 ,  A61K31/421 ,  A61K31/4439 ,  A61K31/451 ,  A61K31/55 ,  A61P9/00 ,  A61P25/16 ,  A61P25/28 ,  A61P43/00 ,  C07D207/26 ,  C07D207/267 ,  C07D207/27 ,  C07D211/76 ,  C07D223/10 ,  C07D263/20 ,  C07D263/22 ,  C07D401/04 ,  A61K31/426 ,  A61K31/4164

CPC classification number: C07D207/267 ,  C07D211/76 ,  C07D223/10 ,  C07D263/22

Abstract: The present invention relates to novel hydroxyethylene compounds having Asp2 (β-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated β-amyloid levels or β-amyloid deposits, particularly Alzheimer's disease.

Abstract translation: 本发明涉及具有Asp2（β-分泌酶，BACE1或Memapsin）抑制活性的新型羟基亚乙基化合物，其制备方法，含有它们的组合物及其用于治疗以β-淀粉样蛋白升高或β- 淀粉样沉积物，特别是阿尔茨海默氏病。

公开(公告)号：US09183822B2

公开(公告)日：2015-11-10

申请号：US13478671

申请日：2012-05-23

Applicant: Luke David MacPherson

Inventor： Luke David MacPherson

IPC: G10H7/00 ,  G10H1/46 ,  G10H1/42

CPC classification number: G10H1/0008 ,  G10H1/42 ,  G10H1/46 ,  G10H2210/391 ,  G10H2220/371 ,  G10H2240/131

Abstract: Methods, devices, systems, and computer programs are presented for providing music while exercising. One method includes an operation for receiving a request for a music segment from a computing device. The request includes the pace of exercise of a user associated with the computing device. The music segment is selected based on the pace, and the music segment is modified to correlate the tempo of the music segment to the pace of exercise. The modified music segment is sent to the computing device to be played in one or more speakers to provide music that is correlated to the exercise.

Abstract translation: 呈现方法，设备，系统和计算机程序，用于在运动时提供音乐。 一种方法包括从计算设备接收对音乐段的请求的操作。 该请求包括与计算设备相关联的用户的锻炼速度。 根据节奏选择音乐片段，修改音乐片段以将音乐片段的节奏与运动速度相关联。 经修改的音乐段被发送到计算设备以在一个或多个扬声器中播放以提供与该练习相关的音乐。

公开(公告)号：US08719791B1

公开(公告)日：2014-05-06

申请号：US13484433

申请日：2012-05-31

Applicant: Luke David MacPherson ,  Shane Stephens

Inventor： Luke David MacPherson ,  Shane Stephens

IPC: G06F9/44

CPC classification number: G06F11/3664 ,  G06F9/4486 ,  G06F11/36 ,  G06F11/3636

Abstract: Embodiments described herein relate to systems and methods for displaying aggregated stack traces in a source code viewer. One or more execution identifiers are received in response to an execution of a first program executing on one or more client computing devices. Each execution identifier can include one or more stack frames, which correspond to a function call within the first program. An error-likeliness score is identified for each execution identifier. An error-weight is determined for each of the execution identifiers based on the identified error-likeliness scores for instances of the execution identifiers.

Abstract translation: 本文描述的实施例涉及用于在源代码查看器中显示聚合堆栈跟踪的系统和方法。 响应于在一个或多个客户端计算设备上执行的第一程序的执行而接收一个或多个执行标识符。 每个执行标识符可以包括与第一程序内的功能调用相对应的一个或多个堆栈帧。 针对每个执行标识符识别错误可能性得分。 基于针对执行标识符的实例的所识别的错误可能性分数，确定每个执行标识符的错误权重。

公开(公告)号：US08488577B1

公开(公告)日：2013-07-16

申请号：US13489756

申请日：2012-06-06

Applicant: Luke David MacPherson

Inventor： Luke David MacPherson

IPC: H04W4/00

CPC classification number: H04L45/308 ,  H04L12/5692 ,  H04L45/54 ,  H04W48/18 ,  H04W88/06

Abstract: Embodiments relate to systems and methods for controlling network access that includes receiving, at a network layer of a protocol stack of a mobile computing device comprising two or more communications interfaces, one or more data packets from an application executing on the mobile computing device, wherein the two or more communication interfaces comprise a cellular communication interface and a wireless network interface; identifying, at the network layer upon receiving the data packet, one or more rules that specify at least one of a plurality of networks to utilize to transmit the data packet, based on the one or more rules, selecting, in the network layer, a communication interface from the two or more communications interfaces associated with the at least one of the plurality of networks for transmitting the one or more data packets.

Abstract translation: 实施例涉及用于控制网络接入的系统和方法，其包括在包括两个或多个通信接口的移动计算设备的协议栈的网络层处接收来自在移动计算设备上执行的应用的一个或多个数据分组，其中 两个或更多个通信接口包括蜂窝通信接口和无线网络接口; 在接收到所述数据分组时在所述网络层处识别指定多个网络中的至少一个以利用所述一个或多个规则来发送所述数据分组的一个或多个规则，在所述网络层中选择一个 来自与所述多个网络中的至少一个网络相关联的两个或更多个通信接口的通信接口，用于发送所述一个或多个数据分组。

公开(公告)号：US5842929A

公开(公告)日：1998-12-01

申请号：US697870

申请日：1996-08-30

Applicant: Erick R. Moody ,  William Sias ,  David MacPherson ,  Thomas G. Phee

Inventor： Erick R. Moody ,  William Sias ,  David MacPherson ,  Thomas G. Phee

IPC: A63D5/00 ,  A63D5/04 ,  G06F19/00 ,  A63F9/22

CPC classification number: A63D5/04

Abstract: An instant replay system for a bowling scoring system is disclosed in which a video clip of a bowler's approach and deliver of a bowling ball and a video clip of the bowling ball subsequently entering a pin-fall area are filmed, compressed, and stored in a memory device, such as a hard drive. The instant replay system includes a controller for receiving user requests from a user input terminal of the bowling scoring system and for responding to such user requests by selecting a stored video clip and controlling playback of the selected video clip on a display monitor of the bowling scoring system. In this manner, a user may request that the replay video clip be played in at any selected rate, that the controller freeze the display on a specific video frame, and that the controller fast-forward or rewind the video clip. Further, the user may request the replay of any previously stored video clip by specifying the bowler, game, frame and ball of which the video clip is taken. The instant replay system may be networked to similar systems associated with other lanes of the bowling center and networked to a shared video server. The video server may transfer any one or more requested video clip to a VCR for transfer to a video tape at the request of a user entered at a scoring console. Further, the video server may transfer a selected video frame to a printer in response to a user's request.

Abstract translation: 公开了一种用于保龄球计分系统的瞬时重放系统，其中，打包，压缩并存储在保龄球场中的保龄球和保龄球的视频剪辑的视频剪辑随后进入引脚落下区域 内存设备，如硬盘驱动器。 即时重播系统包括控制器，用于从保龄球计分系统的用户输入终端接收用户请求，并且通过选择所存储的视频剪辑并控制所选择的视频剪辑在保龄球得分的显示监视器上的回放来响应这些用户请求 系统。 以这种方式，用户可以请求以任何选定的速率播放重放视频剪辑，控制器将特定视频帧上的显示器冻结，并且控制器快进或快退视频剪辑。 此外，用户可以通过指定拍摄视频剪辑的滚球，游戏，框架和球来请求重播任何先前存储的视频剪辑。 即时重播系统可以联网到与保龄球中心的其他车道相关联并且联网到共享视频服务器的类似系统。 视频服务器可以将任何一个或多个所请求的视频剪辑传送到VCR，以便根据在评分控制台输入的用户的请求传送到视频磁带。 此外，视频服务器可以响应于用户的请求将所选择的视频帧传送到打印机。