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1.发明授权Cyclic hexadepsipeptides, processes for their production and their use as pharmaceuticals 失效环十六肽，其制备方法及其作为药物的用途公开(公告)号：US08076287B2
公开(公告)日：2011-12-13
申请号：US12294213
申请日：2007-03-28
IPC分类号： A61K38/12
CPC分类号： C07K7/06 , A61K38/00 , C12P17/188 , C12P21/02 , C12R1/465
摘要： The present invention provides cyclic hexadepsipeptides and their pharmaceutically acceptable salts, solvates and prodrugs, and methods for obtaining the compounds, by fermentation, optionally followed by post-biosynthesis chemical modification. The present invention further provides uses of cyclic hexadepsipeptides, and their pharmaceutically acceptable salts, solvates and prodrugs as pharmaceuticals, in particular to their use as antibacterial, antifungal or antineoplastic agents, and to pharmaceutical compositions comprising a cyclic hexadepsipeptide, or a pharmaceutically acceptable salt, solvate or prodrug thereof, together with a carrier.
摘要翻译： 本发明提供环状十六肽及其药学上可接受的盐，溶剂合物和前药，以及通过发酵，任选地随后进行生物合成化学修饰来获得化合物的方法。 本发明进一步提供了环状十六肽及其药学上可接受的盐，溶剂合物和前药作为药物，特别是其作为抗细菌剂，抗真菌剂或抗肿瘤剂的用途的用途，以及包含环十六肽或其药学上可接受的盐， 溶剂化物或前药，以及载体。
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2.发明申请CYCLIC HEXADEPSIPEPTIDES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS PHARMACEUTICALS 失效周期性十六烷基硫酸酯，其生产工艺及其作为药物的使用公开(公告)号：US20090215789A1
公开(公告)日：2009-08-27
申请号：US12294213
申请日：2007-03-28
IPC分类号： A61K31/501 , C07D401/14 , C12N1/20 , C12P17/16 , A61P31/04 , A61P35/00
CPC分类号： C07K7/06 , A61K38/00 , C12P17/188 , C12P21/02 , C12R1/465
摘要： The present invention provides cyclic hexadepsipeptides and their pharmaceutically acceptable salts, solvates and prodrugs, and methods for obtaining the compounds, by fermentation, optionally followed by post-biosynthesis chemical modification. The present invention further provides uses of cyclic hexadepsipeptides, and their pharmaceutically acceptable salts, solvates and prodrugs as pharmaceuticals, in particular to their use as antibacterial, antifungal or antineoplastic agents, and to pharmaceutical compositions comprising a cyclic hexadepsipeptide, or a pharmaceutically acceptable salt, solvate or prodrug thereof, together with a carrier.
摘要翻译： 本发明提供环状十六肽及其药学上可接受的盐，溶剂合物和前药，以及通过发酵，任选地随后进行生物合成化学修饰来获得化合物的方法。 本发明进一步提供了环状十六肽及其药学上可接受的盐，溶剂合物和前药作为药物，特别是其作为抗细菌剂，抗真菌剂或抗肿瘤剂的用途的用途，以及包含环十六肽或其药学上可接受的盐， 溶剂化物或前药，以及载体。
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公开(公告)号：US07101872B2
公开(公告)日：2006-09-05
申请号：US10762107
申请日：2004-01-21
IPC分类号： C07D243/10 , A61K31/55
CPC分类号： C12N9/93 , A61K38/00 , C07D243/38 , C07D405/06 , C07D405/14 , C12N9/0004 , C12N9/10 , C12N9/12 , C12N9/14 , C12N9/88 , C12N9/90 , C12N15/52 , C12P17/10 , C12R1/29 , Y02A50/473
摘要： This invention relates to a novel farnesylated dibenzodiazepinone, named ECO-04601, its pharmaceutically acceptable salts and derivatives, and to methods for obtaining such compounds. One method of obtaining the ECO-04601 compound is by cultivation of a novel strain of Micromonospora sp., 046-ECO11; another method involves expression of biosynthetic pathway genes in transformed host cells. The present invention further relates to Micromonospora sp. strain 046-ECO11, to the use of ECO-04601 and its pharmaceutically acceptable salts and derivatives as pharmaceuticals, in particular to their use as inhibitors of cancer cell growth, bacterial cell growth, mammalian lipoxygenase, and to pharmaceutical compositions comprising ECO-04601 or a pharmaceutically acceptable salt or derivative thereof. Finally, the invention relates to novel polynucleotide sequences and their encoded proteins, which are involved in the biosynthesis of ECO-04601.
摘要翻译： 本发明涉及名为ECO-04601的新型法呢基化二苯并二氮杂酮，其药学上可接受的盐和衍生物，以及获得这些化合物的方法。 获得ECO-04601化合物的一种方法是通过培养一种新型的小单孢菌属菌株046-ECO11; 另一种方法涉及在转化的宿主细胞中表达生物合成途径基因。 本发明还涉及小单孢菌属 应用046-ECO11，使用ECO-04601及其药学上可接受的盐和衍生物作为药物，特别是其作为癌细胞生长抑制剂，细菌细胞生长，哺乳动物脂氧合酶的用途，以及包含ECO-04601或 其药学上可接受的盐或衍生物。 最后，本发明涉及参与ECO-04601的生物合成的新型多核苷酸序列及其编码的蛋白质。
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公开(公告)号：US20080199940A1
公开(公告)日：2008-08-21
申请号：US11511586
申请日：2006-08-28
CPC分类号： C12N9/93 , A61K38/00 , C07D243/38 , C07D405/06 , C07D405/14 , C12N9/0004 , C12N9/10 , C12N9/12 , C12N9/14 , C12N9/88 , C12N9/90 , C12N15/52 , C12P17/10 , C12R1/29 , Y02A50/473
摘要： This invention relates to a novel farnesylated dibenzodiazepinone, named ECO-04601, its pharmaceutically acceptable salts and derivatives, and to methods for obtaining such compounds. One method of obtaining the ECO-04601 compound is by cultivation of a novel strain of Micromonospora sp., 046-ECO11; another method involves expression of biosynthetic pathway genes in transformed host cells. The present invention further relates to Micromonospora sp. strain 046-ECO11, to the use of ECO-04601 and its pharmaceutically acceptable salts and derivatives as pharmaceuticals, in particular to their use as inhibitors of cancer cell growth, bacterial cell growth, mammalian lipoxygenase, and to pharmaceutical compositions comprising ECO-04601 or a pharmaceutically acceptable salt or derivative thereof. Finally, the invention relates to novel polynucleotide sequences and their encoded proteins, which are involved in the biosynthesis of ECO-04601.
摘要翻译： 本发明涉及名为ECO-04601的新型法呢基化二苯并二氮杂酮，其药学上可接受的盐和衍生物，以及获得这些化合物的方法。 获得ECO-04601化合物的一种方法是通过培养一种新型的小单孢菌属菌株046-ECO11; 另一种方法涉及在转化的宿主细胞中表达生物合成途径基因。 本发明还涉及小单孢菌属 应用046-ECO11，使用ECO-04601及其药学上可接受的盐和衍生物作为药物，特别是其作为癌细胞生长抑制剂，细菌细胞生长，哺乳动物脂氧合酶的用途，以及包含ECO-04601或 其药学上可接受的盐或衍生物。 最后，本发明涉及参与ECO-04601的生物合成的新型多核苷酸序列及其编码的蛋白质。
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5.发明授权Dibenzodiazepinone analogues, processes for their production and their use as pharmaceuticals 失效二苯并二氮杂酮类似物，其制备方法及其作为药物的用途公开(公告)号：US07655646B2
公开(公告)日：2010-02-02
申请号：US11962855
申请日：2007-12-21
IPC分类号： C07D243/10 , A61K31/55
CPC分类号： C07D243/38 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/14
摘要： The invention relates to biologically active dibenzodiazepinone analogs represented by Formula I, to methods of producing them, to pharmaceutical compositions comprising them and to methods of treating neoplastic conditions.
摘要翻译： 本发明涉及由式I表示的生物活性二苯并二氮杂酮类似物，其制备方法，包含它们的药物组合物和治疗肿瘤病症的方法。
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6.发明申请DIBENZODIAZEPINONE ANALOGUES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS PHARMACEUTICALS 失效二苯并嗪酮类似物，其生产方法及其作为药物的用途公开(公告)号：US20080161291A1
公开(公告)日：2008-07-03
申请号：US11962855
申请日：2007-12-21
IPC分类号： A61K31/551 , C07D243/10
CPC分类号： C07D243/38 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/14
摘要： The invention relates to biologically active dibenzodiazepinone analogs represented by Formula I, to methods of producing them, to pharmaceutical compositions comprising them and to methods of treating neoplastic conditions.
摘要翻译： 本发明涉及由式I表示的生物活性二苯并二氮杂酮类似物，其制备方法，包含它们的药物组合物和治疗肿瘤病症的方法。
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7.发明授权Phosphate prodrugs of a farnesyl dibenzodiazepinone, processes for their production and their use as pharmaceuticals 失效法呢基二苯并二氮杂酮的磷酸酯前药，其制备方法及其作为药物的用途公开(公告)号：US07384935B2
公开(公告)日：2008-06-10
申请号：US11527581
申请日：2006-09-27
申请人： Mustapha Aouidate , James B. McAlpine , Faustinus Yeboah , Ashraf Ibrahim , Arjun H. Banskota , Maxime Ranger , Gregory L. White
发明人： Mustapha Aouidate , James B. McAlpine , Faustinus Yeboah , Ashraf Ibrahim , Arjun H. Banskota , Maxime Ranger , Gregory L. White
IPC分类号： C07D243/10 , A61K31/551 , A61P35/00
CPC分类号： C07D243/10 , C07F9/5535
摘要： This invention relates to phosphate prodrugs of a farnesylated dibenzodiazepinone, to processes of their manufacture, to pharmaceutical compositions comprising the prodrugs, and to their use in the treatment of neoplasms.
摘要翻译： 本发明涉及法呢基化二苯并二氮杂酮的磷酸酯前药，其制备方法，包含前药的药物组合物及其在治疗赘生物中的用途。
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8.发明授权Dibenzodiazepinone analogues, processes for their production and their use as pharmaceuticals 失效二苯并二氮杂酮类似物，其制备方法及其作为药物的用途公开(公告)号：US07304054B2
公开(公告)日：2007-12-04
申请号：US11235398
申请日：2005-09-27
IPC分类号： C07D243/10 , A61K31/551 , A61P35/00
CPC分类号： C12N9/93 , A61K38/00 , C07D243/38 , C07D405/06 , C07D405/14 , C12N9/0004 , C12N9/10 , C12N9/12 , C12N9/14 , C12N9/88 , C12N9/90 , C12N15/52 , C12P17/10 , C12R1/29 , Y02A50/473
摘要： The invention relates to biologically active dibenzodiazepinone analogs represented by Formula I, to methods of producing them, to pharmaceutical compositions comprising them and to methods of treating neoplastic conditions.
摘要翻译： 本发明涉及由式I表示的生物活性二苯并二氮杂酮类似物，其制备方法，包含它们的药物组合物和治疗肿瘤病症的方法。
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9.发明申请Dibenzodiazepinone Analogues, Processes for Their Production and Their Use as Pharmaceuticals 审中-公开二苯并二氮杂酮类似物，其制备方法及其作为药物的用途公开(公告)号：US20090029972A1
公开(公告)日：2009-01-29
申请号：US11663890
申请日：2005-09-26
IPC分类号： A61K31/551 , C07D243/38 , C12N5/06 , A61P35/00
CPC分类号： C07D243/38
摘要： The invention relates to biologically active dibenzodiazepinone analogs represented by Formula I, to methods of producing them, and their use in the preparation of medicaments for the treatment of neoplastic conditions
摘要翻译： 本发明涉及由式I表示的生物活性二苯并二氮杂酮类似物，其生产方法及其在制备用于治疗肿瘤病症的药物中的用途
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公开(公告)号：US07312339B2
公开(公告)日：2007-12-25
申请号：US10865767
申请日：2004-06-14
IPC分类号： C07D207/444 , C07D209/48
CPC分类号： C12R1/60 , C07D263/32 , C07D413/12 , C12P17/14
摘要： Polyene oxazoles of the following formula wherein R3 is selected from H and methyl, are disclosed. Such compounds, and pharmaceutically acceptable salts thereof, may be used in the inhibition of tumor cell growth. The polyene oxazoles and their pharmaceutically acceptable salts may be formulated as pharmaceutical compositions with pharmaceutically acceptable carriers for use in the inhibition of tumor cells. The polyene oxazoles may be obtained from strains of Streptomyces sparsogenes, such as strain 022 having deposit number IDAC 270504-04.
摘要翻译： 公开了下式的多烯恶唑，其中R 3选自H和甲基。 这些化合物及其药学上可接受的盐可用于抑制肿瘤细胞生长。 多烯恶唑及其药学上可接受的盐可以配制成具有用于抑制肿瘤细胞的药学上可接受的载体的药物组合物。 多烯恶唑可以从天竺葵链霉菌菌株获得，例如具有保藏号IDAC 270504-04的菌株022。
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