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公开(公告)号：US20230357258A1
公开(公告)日：2023-11-09
申请号：US18131405
申请日：2023-04-06
发明人： Adam Szymaniak , Robert Leon , Kevin McGrath , Xiben Li , Tyler J. Mann , Jianming Yu , In Jong Kim , Scott Mitchell , Yat Sun Or
IPC分类号： C07D491/048 , A61P31/14 , A61K45/06 , C07D519/00
CPC分类号： C07D491/048 , A61P31/14 , A61K45/06 , C07D519/00 , C07B2200/05
摘要： The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, esters, or prodrugs thereof:
which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.-
公开(公告)号：US20230365525A1
公开(公告)日：2023-11-16
申请号：US18139405
申请日：2023-04-26
发明人： Jianming Yu , Xiben Li , Robert Leon , Adam Szymaniak , In Jong Kim , Yat Sun Or
IPC分类号： C07D401/12 , C07D417/12 , C07D401/14 , C07D413/14 , A61K45/06 , A61P31/14 , C07D471/04 , C07D417/14 , C07D409/14 , C07D405/14
CPC分类号： C07D401/12 , C07D417/12 , C07D401/14 , C07D413/14 , A61K45/06 , A61P31/14 , C07D471/04 , C07D417/14 , C07D409/14 , C07D405/14
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof:
which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the compounds of Formula (I) for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.-
公开(公告)号：US20230115580A1
公开(公告)日：2023-04-13
申请号：US17720079
申请日：2022-04-13
发明人： Adam Szymaniak , Jianming Yu , Kevin McGrath , Xiben Li , Tyler J. Mann , Robert Leon , In Jong Kim , Yat Sun Or , Long Nguyen
IPC分类号： C07D491/048 , C07D519/00 , A61K45/06
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
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公开(公告)号：US11945830B2
公开(公告)日：2024-04-02
申请号：US17679746
申请日：2022-02-24
发明人： Adam Szymaniak , Jianming Yu , Kevin McGrath , Xiben Li , Tyler J. Mann , Robert Leon , In Jong Kim , Yat Sun Or , Long Nguyen
IPC分类号： C07F9/09 , A61K31/14 , A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/444 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/502 , A61K31/519 , A61K45/06 , C07D491/048 , C07D519/00
CPC分类号： C07F9/09 , A61K45/06 , C07D491/048 , C07D519/00
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof:
which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
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