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    4-phenylamino-pyrimidine derivatives having protein kinase inhibitor activity
    6.
    发明授权
    4-phenylamino-pyrimidine derivatives having protein kinase inhibitor activity 有权
    具有蛋白激酶抑制剂活性的4-苯基氨基 - 嘧啶衍生物

    公开(公告)号：US09040529B2

    公开(公告)日：2015-05-26

    申请号：US13517120

    申请日：2010-12-17

    申请人： Zoltán Greff ,  Zoltán Varga ,  György Kéri ,  Gábor Németh ,  László Örfi ,  Csaba Szántai Kis

    发明人： Zoltán Greff ,  Zoltán Varga ,  György Kéri ,  Gábor Németh ,  László Örfi ,  Csaba Szántai Kis

    IPC分类号： A61K31/5377 ,  C07D239/42 ,  C07D401/04 ,  C07D403/04 ,  C07D403/14 ,  C07D409/14

    CPC分类号： C07D239/42 ,  C07D401/04 ,  C07D403/04 ,  C07D403/14 ,  C07D409/14

    摘要： The invention relates compounds of general formula (I) and pharmaceutically acceptable salts and solvates thereof wherein R1 is halogen, vinylene-aryl, substituted aryl, heteroaryl or a benzo[1,3]dioxolil group, W is a group of formula —NH—SO2—R2 or heteroaryl group or NHR3 group where R3 is hydrogen or heteroaryl; and n is 1, 2, 3 or 4. Furthermore, the present invention is directed to pharmaceutical composition containing at least one compound of general formula (I) and/or pharmaceutically acceptable salts or solvates thereof and for the use of them for the preparation of pharmaceutical compositions for the prophylaxis and/or the treatment of protein kinase related, especially CDK9-related diseases e.g. cell proliferative disease, infectious disease, pain, cardiovascular disease and inflammation.

    摘要翻译： 本发明涉及通式（I）的化合物及其药学上可接受的盐和溶剂化物，其中R 1是卤素，亚乙烯基 - 芳基，取代的芳基，杂芳基或苯并[1,3]二氧杂环戊烷基，W是式-NH- SO 2 -R 2或杂芳基或NHR 3基团，其中R 3是氢或杂芳基; 此外，本发明涉及含有至少一种通式（I）的化合物和/或其药学上可接受的盐或溶剂化物的药物组合物，并且用于制备它们 用于预防和/或治疗蛋白激酶相关的药物组合物，特别是CDK9相关疾病，例如 细胞增殖性疾病，感染性疾病，疼痛，心血管疾病和炎症。

    4-PHENYLAMINO-PYRIMIDINE DERIVATIVES HAVING PROTEIN KINASE INHIBITOR ACTIVITY
    7.
    发明申请
    4-PHENYLAMINO-PYRIMIDINE DERIVATIVES HAVING PROTEIN KINASE INHIBITOR ACTIVITY 有权
    具有蛋白激酶抑制剂活性的4-苯基氨基吡啶衍生物

    公开(公告)号：US20120258968A1

    公开(公告)日：2012-10-11

    申请号：US13517120

    申请日：2010-12-17

    申请人： Zoltán Greff ,  Zoltán Varga ,  György Kéri ,  Gábor Németh ,  László Örfi ,  Csaba Szántai Kis

    发明人： Zoltán Greff ,  Zoltán Varga ,  György Kéri ,  Gábor Németh ,  László Örfi ,  Csaba Szántai Kis

    IPC分类号： A61K31/505 ,  C07D413/12 ,  A61P9/00 ,  A61P31/00 ,  A61P29/00 ,  C07D239/42 ,  A61K31/5377

    CPC分类号： C07D239/42 ,  C07D401/04 ,  C07D403/04 ,  C07D403/14 ,  C07D409/14

    摘要： The invention relates compounds of general formula (I) and pharmaceutically acceptable salts and solvates thereof wherein R1 is halogen, vinylene-aryl, substituted aryl, heteroaryl or a benzo[1,3]dioxolil group, W is a group of formula —NH—SO2—R2 or heteroaryl group or NHR3 group where R3 is hydrogen or heteroaryl; and n is 1, 2, 3 or 4. Furthermore, the present invention is directed to pharmaceutical composition containing at least one compound of general formula (I) and/or pharmaceutically acceptable salts or solvates thereof and for the use of them for the preparation of pharmaceutical compositions for the prophylaxis and/or the treatment of protein kinase related, especially CDK9-related diseases e.g. cell proliferative disease, infectious disease, pain, cardiovascular disease and inflammation.

    摘要翻译： 本发明涉及通式（I）的化合物及其药学上可接受的盐和溶剂化物，其中R 1是卤素，亚乙烯基 - 芳基，取代的芳基，杂芳基或苯并[1,3]二氧杂环戊烷基，W是式-NH- SO 2 -R 2或杂芳基或NHR 3基团，其中R 3是氢或杂芳基; 此外，本发明涉及含有至少一种通式（I）的化合物和/或其药学上可接受的盐或溶剂化物的药物组合物，并且用于制备它们 用于预防和/或治疗蛋白激酶相关的药物组合物，特别是CDK9相关疾病，例如 细胞增殖性疾病，感染性疾病，疼痛，心血管疾病和炎症。