公开(公告)号：US5497769A

公开(公告)日：1996-03-12

申请号：US168813

申请日：1993-12-16

申请人： Enrico Gratton ,  Sergio Fantini ,  Maria A. Franceschini ,  William Mantulin ,  Beniamino Barbieri

发明人： Enrico Gratton ,  Sergio Fantini ,  Maria A. Franceschini ,  William Mantulin ,  Beniamino Barbieri

IPC分类号： A61B5/00 ,  G01N21/31 ,  G01N21/49

CPC分类号： A61B5/14552 ,  A61B5/0059 ,  A61B5/14532 ,  A61B5/1455 ,  G01N21/314 ,  G01N21/49 ,  A61B2562/0233 ,  A61B2562/046

摘要： The quantitative determination of various materials in highly scattering media such as living tissue may be determined in an external, photometric manner by the use of a plurality of light sources positioned at differing distances from a sensor. The light from said sources is amplitude modulated, and, in accordance with conventional frequency domain fluorometry or phosphorimetry techniques, the gain of the sensor is modulated at a frequency different from the frequency of the light modulation. Data may be acquired from each of the light sources at differing distances at a frequency which is the difference between the two frequencies described above. From these sets of data from each individual light source, curves may be constructed, and the slopes used to quantitatively determine the amount of certain materials present, for example oxyhemoglobin and deoxyhemoglobin in living tissue.

摘要翻译： 可以通过使用位于与传感器不同的距离的多个光源以外部的光度方式来确定诸如活组织的高度散射介质中的各种材料的定量测定。 来自所述源的光被幅度调制，并且根据常规的频域荧光测定或荧光测定技术，传感器的增益以不同于光调制频率的频率进行调制。 可以以作为上述两个频率之间的差的频率以不同的距离从每个光源获取数据。 根据来自每个单独光源的这些数据集，可以构建曲线，并且用于定量确定存在的某些材料的量的斜率，例如活体组织中的氧合血红蛋白和脱氧血红蛋白。

公开(公告)号：US5492118A

公开(公告)日：1996-02-20

申请号：US253935

申请日：1994-06-03

申请人： Enrico Gratton ,  John Maier ,  Maria A. Franceschini ,  Sergio Fantini ,  Scott A. Walker

发明人： Enrico Gratton ,  John Maier ,  Maria A. Franceschini ,  Sergio Fantini ,  Scott A. Walker

IPC分类号： A61B10/00 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/31 ,  G01N21/49

CPC分类号： G01N21/314 ,  A61B5/0059 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/14552 ,  G01N21/49 ,  A61B2562/0233 ,  A61B2562/046 ,  A61B5/6824

摘要： The relative concentration of a material such as glucose in a turbid medium such as living tissue may determining the scattering coefficient of the light that has passed through the turbid medium; and comparing the scattering coefficient with a previous scattering coefficient determined with respect to the turbid medium.

摘要翻译： 诸如生物组织等混浊介质中的葡萄糖等物质的相对浓度可以确定通过混浊介质的光的散射系数; 并将散射系数与相对于混浊介质确定的先前散射系数进行比较。