利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

68 条记录 (耗时 0.036 秒)

    Inhibitors of protein kinases
    1.
    发明申请
    Inhibitors of protein kinases 审中-公开
    蛋白激酶抑制剂

    公开(公告)号：US20070185098A1

    公开(公告)日：2007-08-09

    申请号：US11649363

    申请日：2007-01-04

    申请人： Enrique Michelotti ,  William Moore ,  Eric Springman

    发明人： Enrique Michelotti ,  William Moore ,  Eric Springman

    IPC分类号： A61K31/541 ,  A61K31/519 ,  C07D211/72 ,  C07D491/02 ,  C07D417/02

    CPC分类号： C07D417/12 ,  C07D213/68 ,  C07D213/81 ,  C07D491/04

    摘要： The present invention is directed to a compound having the formula wherein R1, R2, R3, R4, G, and Q are defined herein. The compounds of the present invention are useful as inhibitors of protein kinases. The present invention is also directed to compositions comprising a compound according to the above formula. The present invention is also directed to compounds that stabilize the open conformation of a protein kinase, a crystallized protein kinase in the open conformation, and uses thereof. The compounds and compositions described herein are useful for treating and preventing an inflammatory condition or disease.

    摘要翻译： 本发明涉及具有下式的化合物：其中R 1，R 2，R 3，R 4， >，G和Q在本文中定义。 本发明的化合物可用作蛋白激酶的抑制剂。 本发明还涉及包含根据上式的化合物的组合物。 本发明还涉及稳定蛋白激酶，开放构象中的结晶蛋白激酶的开放构象的化合物及其用途。 本文所述的化合物和组合物可用于治疗和预防炎性疾病或疾病。

    User and stream demographics metadata guide based content services
    4.
    发明授权
    User and stream demographics metadata guide based content services 有权
    用户和流人口统计元数据指南的内容服务

    公开(公告)号：US08756101B2

    公开(公告)日：2014-06-17

    申请号：US12011478

    申请日：2008-01-25

    申请人： William Moore ,  Thomas Hutchings ,  David McIntosh ,  Edwin J. Lau

    发明人： William Moore ,  Thomas Hutchings ,  David McIntosh ,  Edwin J. Lau

    IPC分类号： G06F15/16 ,  G06Q30/00

    CPC分类号： G06Q30/0224 ,  G06Q30/02 ,  G06Q30/0258 ,  G06Q30/0277

    摘要： A metadata guide of audio, video, multimedia transmission, receiving and playback with advertising and bi-directional fulfillment of goods and services over the Internet includes the use of user and stream demographics. A streaming content distribution system includes a a server to a) stream content based on i) user demographics and ii) historical and real time stream demographics from a plurality of streaming content sources and b) stream advertisements based on user demographics selected by advertisers, commercial agreements and access control rules from a plurality of streaming advertisement sources before, during, and after playback of streaming content from the server over the internet to a user device including a central processing unit and a physical user interface; and a guide including metadata not input by the users for the user device to locate streaming content on the server.

    摘要翻译： 音频，视频，多媒体传输，接收和播放以及通过互联网广告和双向实现商品和服务的元数据指南包括使用用户和流人口统计。 流式传输内容分发系统包括以下服务器：a）基于i）用户人口统计流量流内容; ii）来自多个流式传输内容源的历史和实时流人口统计;以及b）基于由广告商选择的用户人口统计资料的流广告，商业协议 以及来自多个流媒体广播源的访问控制规则，在通过互联网从服务器播放流媒体内容之前，之中和之后到包括中央处理单元和物理用户界面的用户设备; 以及包括用户设备未输入的元数据以指导服务器上的流媒体内容的指南。

    Methods of manufacturing and modifying taxane coatings for implantable medical devices
    5.
    发明申请
    Methods of manufacturing and modifying taxane coatings for implantable medical devices 有权
    制造和修饰可植入医疗器械的紫杉烷涂层的方法

    公开(公告)号：US20080020013A1

    公开(公告)日：2008-01-24

    申请号：US11823283

    申请日：2007-06-27

    申请人： Priscilla Reyes ,  William Moore ,  Randy Myers ,  Patrick Ruane

    发明人： Priscilla Reyes ,  William Moore ,  Randy Myers ,  Patrick Ruane

    IPC分类号： A61F2/00 ,  A61K31/335

    CPC分类号： A61K31/335 ,  A61F2/0095 ,  A61F2/91 ,  A61F2250/0067 ,  A61F2250/0091

    摘要： This disclosure relates to endolumenal medical devices coated with a taxane therapeutic agent in one or more solid form(s) having varying dissolution rates. Particularly preferred coatings comprise amorphous paclitaxel, dihydrate paclitaxel, or combinations thereof that provide durable coatings that release paclitaxel over a desired period of time, which can be on the order of hours, days or weeks. Preferred embodiments relate to medical device coatings of paclitaxel, or paclitaxel analogs or derivatives, having one or more polymorph solid forms that provide a prolonged release of paclitaxel within a body vessel without requiring a polymer carrier or barrier layer to achieve the desired rate of paclitaxel elution.

    摘要翻译： 本公开涉及用一种或多种具有不同溶解速率的固体形式涂覆紫杉烷治疗剂的腔内医疗器械。 特别优选的涂层包括无定形紫杉醇，二水合紫杉醇或其组合，其提供耐久性涂层，其在期望的时间段内释放紫杉醇，其可以是数小时，数天或数周的数量级。 优选实施方案涉及具有一种或多种多晶型固体形式的紫杉醇或紫杉醇类似物或衍生物的医疗器械涂层，其提供紫杉醇在体内容器内的延长释放，而不需要聚合物载体或阻挡层来实现所需的紫杉醇洗脱速率 。

    I/O dependency graphs
    6.
    发明申请
    I/O dependency graphs 有权
    I / O依赖关系图

    公开(公告)号：US20070174494A1

    公开(公告)日：2007-07-26

    申请号：US11407614

    申请日：2006-04-20

    申请人： Jeffrey Bonwick ,  William Moore

    发明人： Jeffrey Bonwick ,  William Moore

    IPC分类号： G06F3/00

    CPC分类号： G06F3/0659 ,  G06F3/0611 ,  G06F3/0613 ,  G06F3/0689 ,  G06F13/385

    摘要： A method for executing a selected input/output (I/O) command from a plurality of I/O commands based on a dependency graph of I/O commands includes building the dependency graph of I/O commands, wherein the dependency graph is built by requiring all children of the selected I/O command to be ready before the selected I/O command is ready, and executing the I/O command based on the dependency graph, wherein execution of the selected I/O command is completed when all of the children of the selected I/O command finish execution.

    摘要翻译： 基于I / O命令的依赖图来执行来自多个I / O命令的选择的输入/输出（I / O）命令的方法包括建立I / O命令的依赖图，其中构建依赖图 通过在选择的I / O命令准备就绪之前，要求所有I / O命令的所有子项都准备就绪，并且基于依赖关系图执行I / O命令，其中所有I / O命令的执行在完成时 的所选I / O命令的子项完成执行。

    Method and system for data replication
    7.
    发明申请
    Method and system for data replication 有权
    数据复制的方法和系统

    公开(公告)号：US20070124659A1

    公开(公告)日：2007-05-31

    申请号：US11434296

    申请日：2006-05-15

    申请人： William Moore ,  Jeffrey Bonwick ,  Matthew Ahrens

    发明人： William Moore ,  Jeffrey Bonwick ,  Matthew Ahrens

    IPC分类号： G06F11/00 ,  H03M13/00

    CPC分类号： G06F11/1076 ,  G06F2211/1059

    摘要： A method for writing data to a storage pool includes receiving a write operation to write a logical block of data to the storage pool, determining a number (n−1) of physical blocks required to store the logical block of data, generating a parity block using the logical block of data, allocating n physical blocks in the storage pool, writing the parity block in the first of n allocated physical block, and writing the logical block of data across the remaining n−1 allocated physical blocks, where n is less than a number of disks in the storage pool, and where each of the n allocated physical blocks is located on a different disk in the storage pool.

    摘要翻译： 一种将数据写入存储池的方法包括接收写入操作以将数据的逻辑块写入存储池，确定存储逻辑数据块所需的数量（n-1）个物理块，产生奇偶校验块 使用逻辑数据块，在存储池中分配n个物理块，将奇偶校验块写入n个分配的物理块中的第一个，并将逻辑数据块写入剩余的n-1个分配的物理块，其中n少于 比存储池中的多个磁盘，并且其中每个n个分配的物理块位于存储池中的不同磁盘上。

    Method and system for pruned resilvering using a dirty time log
    8.
    发明申请
    Method and system for pruned resilvering using a dirty time log 有权
    使用脏时间日志修剪弹性的方法和系统

    公开(公告)号：US20070106677A1

    公开(公告)日：2007-05-10

    申请号：US11409427

    申请日：2006-04-19

    申请人： William Moore ,  Jeffrey Bonwick ,  Matthew Ahrens

    发明人： William Moore ,  Jeffrey Bonwick ,  Matthew Ahrens

    IPC分类号： G06F7/00

    CPC分类号： G06F11/1435 ,  G06F11/2082

    摘要： A computer readable medium includes executable instructions for resilvering a hierarchical block tree in a storage pool by traversing a branch of the hierarchical block tree only if a birth time of a parent block of the branch is greater than or equal to a lowest birth time on a dirty time log (DTL), and resilvering a child block in the branch only if the DTL comprises a birth time of the child block.

    摘要翻译： 计算机可读介质包括用于通过遍历分层块树的分支来恢复存储池中的分层块树的可执行指令，只有当分支的父块的出生时间大于或等于分支块树的最低出生时间时 脏时间日志（DTL），并且如果DTL包括子块的出生时间，则在分支中恢复子块。

    Customized table tops
    10.
    发明授权
    Customized table tops 失效
    定制桌面

    公开(公告)号：US06367392B2

    公开(公告)日：2002-04-09

    申请号：US09343811

    申请日：1999-06-30

    申请人： William Moore

    发明人： William Moore

    IPC分类号： A47B1308

    CPC分类号： G09F23/00 ,  A47B13/12

    摘要： A table top having a transparent cover through which inserts, such as advertisements, etc. can be viewed. The table top is configured for affixation to a base. The table top comprises a frame having sides, an underlay and a transparent cover. A cavity is formed in the base and is defined by the frame and base. The underlay and transparent cover are substantially planar and are configured to fit within the frame adjacent to each other. The insert is configured to be held between the cover and underlay such that one side of the insert is viewable through the cover.

    摘要翻译： 具有透明盖的桌面，通过该透明盖可以看到诸如广告等的插入物。 桌面配置为固定到基地。 桌面包括具有侧面的框架，底板和透明盖。 在基座中形成空腔，由框架和底座限定。 底层和透明盖基本上是平面的并且被配置成装配在彼此相邻的框架内。 插入件构造成保持在盖和底垫之间，使得插入物的一侧可以通过盖可视。