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    Device for administering an at least two-component substance
    1.
    发明申请
    Device for administering an at least two-component substance 审中-公开
    用于施用至少两种组分物质的装置

    公开(公告)号：US20100217231A1

    公开(公告)日：2010-08-26

    申请号：US12708453

    申请日：2010-02-18

    申请人： Erez Ilan ,  Moti Meron ,  Kfir Regev ,  Liliana Bar ,  Israel Nur

    发明人： Erez Ilan ,  Moti Meron ,  Kfir Regev ,  Liliana Bar ,  Israel Nur

    IPC分类号： A61M5/31 ,  A61B17/03 ,  A61M35/00

    CPC分类号： A61M5/1582 ,  A61B17/00491 ,  A61B2017/00495 ,  A61M5/3297 ,  A61M2025/0039

    摘要： The device for administering an at least two-component substance comprises a concentric lumen arrangement including (i) an inner cannula having a lumen with an inlet opening at a first end and a tip with an outlet opening at a second end opposite its first end, and (ii) an outer sheath having opposite first and second ends facing the respective first and second ends of the inner cannula, and surrounding the inner cannula along an axial length between the first and second ends of the inner cannula, wherein the outer sheath at its second end is sealingly and fixedly connected to the inner cannula and defining an outer lumen around the inner cannula, and wherein the inner cannula is provided with at least one opening for providing fluid communication between the outer lumen around the inner cannula and the lumen of the inner cannula.

    摘要翻译： 用于施用至少两种组分物质的装置包括同心的腔排列，其包括（i）具有在第一端具有入口开口的内腔和在其第一端相对的第二端处具有出口开口的末端的内套管， 和（ii）外护套，其具有相对的第一和第二端面向所述内套管的相应的第一和第二端，并且沿着所述内套管的第一和第二端之间的轴向长度包围所述内套管，其中， 其第二端密封地和固定地连接到内套管并且围绕内插管限定外腔，并且其中内插管设置有至少一个开口，用于提供围绕内插管的外腔与内套管之间的流体连通 内套管。

    Method and Device for Fast Dissolution of Solid Protein Composition
    2.
    发明申请
    Method and Device for Fast Dissolution of Solid Protein Composition 审中-公开
    用于快速溶解固体蛋白质组合物的方法和装置

    公开(公告)号：US20130312868A1

    公开(公告)日：2013-11-28

    申请号：US13722348

    申请日：2012-12-20

    申请人： Erez Ilan ,  Kfir Regev ,  Dana Leitman ,  Israel Nur ,  Moti Meron ,  John Goodman

    发明人： Erez Ilan ,  Kfir Regev ,  Dana Leitman ,  Israel Nur ,  Moti Meron ,  John Goodman

    IPC分类号： C07K14/75

    CPC分类号： C07K14/75 ,  A61M5/19 ,  A61M5/284 ,  B01F3/12 ,  B01F5/0685 ,  B01F13/0023 ,  B01F13/0052 ,  B01F15/0225 ,  B01F15/0258

    摘要： Provided are methods and devices for dissolving solid protein compositions, such as solid compositions comprising fibrinogen, in an aqueous solvent. The methods comprise use of a closed container containing a volume of solid fibrinogen composition and a head space wherein the pressure within the headspace is sub-atmospheric. Aqueous solvent is introduced into the container while maintain the sub-atmospheric pressure, and subsequent to addition of the solvent, the size of the headspace is decreased to bring the pressure to atmospheric pressure. The devices are suitable for use in the disclosed method.

    摘要翻译： 提供了用于将固体蛋白质组合物（例如包含纤维蛋白原的固体组合物）溶解在水性溶剂中的方法和装置。 所述方法包括使用含有一定体积的固体纤维蛋白原组合物的封闭容器和顶部空间，其中顶部空间内的压力低于大气压。 将水溶剂引入容器中同时保持低于大气压的压力，然后加入溶剂后，顶部空间的尺寸减小，使压力达到大气压。 这些装置适用于所公开的方法。

    SYNERGISTIC ANTI-OXIDANT TREATMENT FOR LIPOTOXICITY AND OTHER METABOLICALLY RELATED PHENOMENA
    5.
    发明申请
    SYNERGISTIC ANTI-OXIDANT TREATMENT FOR LIPOTOXICITY AND OTHER METABOLICALLY RELATED PHENOMENA 审中-公开
    协同抗氧化剂治疗脂多糖和其他代谢相关物质

    公开(公告)号：US20100210718A1

    公开(公告)日：2010-08-19

    申请号：US12633999

    申请日：2009-12-09

    申请人： Oren TIROSH ,  Zecharia Madar ,  Anna Aronis ,  Erez Ilan

    发明人： Oren TIROSH ,  Zecharia Madar ,  Anna Aronis ,  Erez Ilan

    IPC分类号： A61K31/375 ,  A61P3/10 ,  A61P9/00 ,  A61P9/12 ,  A61P29/00 ,  C12N5/07

    CPC分类号： A61K31/05 ,  A61K31/198 ,  A61K31/341 ,  A61K31/375 ,  A61K2300/00

    摘要： A method for ameliorating, reducing, and/or preventing lipotoxicity-induced metabolic dysfunction in at least one cell is disclosed, said method comprising a step of contacting said at least one cell with a therapeutically effective amount of a synergistic anti-lipotoxicity cocktail, said cocktail comprising N-acetylcysteine, ascorbic acid, and resveratrol. Also disclosed is a method for treating at least one lipotoxicity-related metabolic disorder chosen from the group comprising (a) metabolic syndrome; (b) non-alcoholic steatohepatitis; (c) obesity; and (d) coronary heart disease, said method comprising the step of administering to a patient a therapeutically effective amount of an anti-lipotoxicity cocktail, said cocktail comprising N-acetylcysteine, ascorbic acid, and resveratrol. Finally, a composition for treating the effects of lipotoxicity, containing a synergistic combination of N-acetylcysteine, ascorbic acid, and resveratrol is disclosed.

    摘要翻译： 公开了一种在至少一种细胞中改善，减少和/或预防脂毒性诱导的代谢功能障碍的方法，所述方法包括使所述至少一种细胞与治疗有效量的协同抗脂毒性混合物接触的步骤，所述方法包括： 包含N-乙酰半胱氨酸，抗坏血酸和白藜芦醇的混合物。 还公开了一种治疗选自以下的脂毒素毒性相关的代谢紊乱的方法：（a）代谢综合征; （b）非酒精性脂肪性肝炎; （c）肥胖; 所述方法包括向患者施用治疗有效量的抗 - 脂毒性混合物的步骤，所述混合物包含N-乙酰半胱氨酸，抗坏血酸和白藜芦醇。 最后，公开了一种用于治疗含有N-乙酰半胱氨酸，抗坏血酸和白藜芦醇的协同组合的脂毒性作用的组合物。

    Means and method for treating lipotoxicity and other metabolically related phenomena
    6.
    发明申请
    Means and method for treating lipotoxicity and other metabolically related phenomena 审中-公开
    治疗脂毒性和其他代谢相关现象的手段和方法

    公开(公告)号：US20080015251A1

    公开(公告)日：2008-01-17

    申请号：US11783609

    申请日：2007-04-10

    申请人： Oren Tirosh ,  Zecharia Madar ,  Anna Aronis ,  Erez Ilan

    发明人： Oren Tirosh ,  Zecharia Madar ,  Anna Aronis ,  Erez Ilan

    IPC分类号： A61K31/341 ,  A61P3/00 ,  A61P9/00

    CPC分类号： A61K31/341

    摘要： A method for treating symptoms of a lipotoxicity-related phenomenon includes introducing into a patient a therapeutically effective synergistic amount of a phenomenon-inhibiting cocktail of a polyphenol (P), thiol antioxidant (To) and ascorbic acid (A) to reduce intracellular reactive oxygen species (ROS) and/or increase intracellular nitrite (NO), so that reduction of such phenomenon is at least 30% greater than the reduction of such phenomenon provided by separate administration of each of P, To and A.

    摘要翻译： 用于治疗与脂毒性相关现象的症状的方法包括将多酚（P），硫醇抗氧化剂（To）和抗坏血酸（A））的现象抑制混合物的治疗有效协同量引入患者以减少细胞内活性氧 物种（ROS）和/或增加细胞内亚硝酸盐（NO），因此这种现象的减少比通过分别施用P，To和A中的每一个而提供的这种现象的减少至少高30％。