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    Layer-by-layer stereocomplexed polymers as drug depot carriers or coatings in medical devices
    3.
    发明授权
    Layer-by-layer stereocomplexed polymers as drug depot carriers or coatings in medical devices 有权

    公开(公告)号：US09603980B2

    公开(公告)日：2017-03-28

    申请号：US12037307

    申请日：2008-02-26

    申请人： Jonathon Z. Zhao

    发明人： Jonathon Z. Zhao

    IPC分类号： A61L31/16 ,  A61L31/10

    CPC分类号： A61L31/16 ,  A61L31/10 ,  A61L2300/45 ,  A61L2300/604 ,  A61L2300/61 ,  C08L67/04

    摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the prevention of thrombosis. The drugs, agents, and/or compounds may also be utilized to treat specific disorders, including vulnerable plaque, and atherosclerosis in type 2 diabetic patients. Therapeutic agents may also be delivered to the region of a disease site. In regional delivery, liquid formulations may be desirable to increase the efficacy and deliverability of the particular drug. Various materials and coating methodologies may be utilized to maintain the agents or compounds on the medical device until delivered and positioned.

    COATINGS WITH TUNABLE SOLUBILITY PROFILE FOR DRUG-COATED BALLOON
    6.
    发明申请
    COATINGS WITH TUNABLE SOLUBILITY PROFILE FOR DRUG-COATED BALLOON 审中-公开
    涂料与可溶性溶剂配方用于药物包衣的气球

    公开(公告)号：US20140025005A1

    公开(公告)日：2014-01-23

    申请号：US13911962

    申请日：2013-06-06

    申请人： Abbott Cardiovascular Systems Inc.

    发明人： John J. Stankus ,  Mikael Trollsas ,  Syed Hossainy

    IPC分类号： A61L29/08

    CPC分类号： A61L29/085 ,  A61L29/16 ,  A61L2300/416 ,  A61L2300/608 ,  A61L2300/61

    摘要： A drug delivery balloon is provided, the a balloon having an outer surface, and a tunable coating disposed on at least a length of the balloon surface. The tunable coating includes a first therapeutic agent and a first excipient, and a second therapeutic agent and a second excipient. The first and second therapeutic agents have different dissolution rates during balloon inflation and therefore provide a coating that is tunable.

    摘要翻译： 提供药物递送球囊，具有外表面的气囊和设置在球囊表面的至少一段长度上的可调涂层。 可调涂层包括第一治疗剂和第一赋形剂，以及第二治疗剂和第二赋形剂。 第一和第二治疗剂在球囊膨胀期间具有不同的溶解速率，因此提供可调谐的涂层。

    Substrates providing multiple releases of active agents
    7.
    发明授权
    Substrates providing multiple releases of active agents 有权
    提供活性剂多次释放的底物

    公开(公告)号：US08551517B2

    公开(公告)日：2013-10-08

    申请号：US12336243

    申请日：2008-12-16

    申请人： Douglas Robert Hoffman ,  Andrea Jo Smiltneek ,  Sara Ann Carney ,  Scott W. Wenzel ,  David William Koenig ,  Jeffery Richard Seidling

    发明人： Douglas Robert Hoffman ,  Andrea Jo Smiltneek ,  Sara Ann Carney ,  Scott W. Wenzel ,  David William Koenig ,  Jeffery Richard Seidling

    IPC分类号： A61K9/70 ,  A61L31/12 ,  A61L2/232 ,  A01N25/34

    CPC分类号： A61K9/7007 ,  A61K9/0024 ,  A61K31/00 ,  A61L15/22 ,  A61L15/44 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/61

    摘要： The present disclosure comprises a polymeric substrate that provides multiple releases of active agents. A substrate for multiple phase delivery of active agents is provided having a first polymer matrix layer having a first active agent disposed therein, a second polymer matrix layer having a second active agent disposed therein, and a coacervate layer disposed between the first polymer matrix layer and the second polymer matrix layer. Selected first and second active agents are included in the first and second polymer matrices such that as the first and second polymer matrices dissolve, the active agents are released. Multiple phase active agent release is achieved by constructing multiple layers of a polymer matrix containing an active agents formed with polymers having different solubility characteristics or with active agents at different concentration levels.

    摘要翻译： 本公开内容包括提供活性剂多次释放的聚合物基质。 提供一种用于多相递送活性剂的底物，其具有设置在其中的第一活性剂的第一聚合物基质层，其中设置有第二活性剂的第二聚合物基质层和设置在第一聚合物基质层和第二聚合物基质层之间的凝聚层， 第二聚合物基质层。 选择的第一和第二活性剂包括在第一和第二聚合物基质中，使得当第一和第二聚合物基质溶解时，活性剂被释放。 通过构建多层含有由不同溶解度特征的聚合物形成的活性剂或具有不同浓度水平的活性剂形成的聚合物基质来实现多相活性剂释放。

    Antithrombotic coating for drug eluting medical devices
    9.
    发明授权
    Antithrombotic coating for drug eluting medical devices 有权
    用于药物洗脱医疗器械的抗血栓涂层

    公开(公告)号：US07947302B2

    公开(公告)日：2011-05-24

    申请号：US12334849

    申请日：2008-12-15

    申请人： Robert Falotico ,  Jonathon Z. Zhao

    发明人： Robert Falotico ,  Jonathon Z. Zhao

    IPC分类号： A61F2/06 ,  A61K47/32

    CPC分类号： A61L33/0029 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/61

    摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned.

    摘要翻译： 可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。 医疗装置可以涂覆任何数量的生物相容性材料。 治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。 这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。 此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括血块的形成。 可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。