公开(公告)号：US07618947B2

公开(公告)日：2009-11-17

申请号：US11213593

申请日：2005-08-25

申请人： Eric G. Marcusson ,  Scott W. Henry ,  Youngsoo Kim ,  Kenneth W. Dobie

发明人： Eric G. Marcusson ,  Scott W. Henry ,  Youngsoo Kim ,  Kenneth W. Dobie

IPC分类号： A61K31/70 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/68

CPC分类号： C12N15/113 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525

摘要： Compounds, compositions and methods are provided for modulating the expression of HIF1-beta. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1-beta. Methods of using these compounds for modulation of HIF1-beta expression and for diagnosis and treatment of diseases and conditions associated with expression of HIF1-beta are provided.

摘要翻译： 提供化合物，组合物和方法用于调节HIF1-β的表达。 组合物包含靶向编码HIF1-β的核酸的寡核苷酸。 提供了使用这些化合物调节HIF1-β表达和用于诊断和治疗与HIF1-β表达相关的疾病和病症的方法。

公开(公告)号：US07799764B2

公开(公告)日：2010-09-21

申请号：US12578468

申请日：2009-10-13

申请人： Eric G. Marcusson ,  Scott W. Henry ,  Youngsoo Kim ,  Kenneth Dobie

发明人： Eric G. Marcusson ,  Scott W. Henry ,  Youngsoo Kim ,  Kenneth Dobie

IPC分类号： A61K31/70 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/68 ,  C12N5/00

CPC分类号： C12N15/113 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525

摘要： Compounds, compositions and methods are provided for modulating the expression of HIF1-beta. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1-beta. Methods of using these compounds for modulation of HIF1-beta expression and for diagnosis and treatment of diseases and conditions associated with expression of HIF1-beta are provided.

摘要翻译： 提供化合物，组合物和方法用于调节HIF1-β的表达。 组合物包含靶向编码HIF1-β的核酸的寡核苷酸。 提供了使用这些化合物调节HIF1-β表达和用于诊断和治疗与HIF1-β表达相关的疾病和病症的方法。

公开(公告)号：US20100113573A1

公开(公告)日：2010-05-06

申请号：US12578468

申请日：2009-10-13

申请人： Eric G. Marcusson ,  Scott W. Henry ,  Youngsoo Kim ,  Kenneth Dobie

发明人： Eric G. Marcusson ,  Scott W. Henry ,  Youngsoo Kim ,  Kenneth Dobie

IPC分类号： A61K31/7088 ,  C07H21/00 ,  A61P35/00 ,  A61P27/02 ,  C12N5/071

CPC分类号： C12N15/113 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525

摘要： Compounds, compositions and methods are provided for modulating the expression of HIF1-beta. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1-beta. Methods of using these compounds for modulation of HIF1-beta expression and for diagnosis and treatment of diseases and conditions associated with expression of HIF1-beta are provided.