公开(公告)号：US08969580B2

公开(公告)日：2015-03-03

申请号：US13517276

申请日：2010-10-08

申请人： Eric Horn ,  Steven Fairway ,  Dimitrios Mantzilas ,  Nigel Powell

发明人： Eric Horn ,  Steven Fairway ,  Dimitrios Mantzilas ,  Nigel Powell

IPC分类号： C07D277/66 ,  A61K51/04 ,  C07B59/00 ,  C07B63/00

CPC分类号： C07D277/66 ,  A61K51/0402 ,  B01D15/26 ,  C07B59/002 ,  C07B63/00 ,  C07B2200/05

摘要： A diagnostic imaging agent useful for positron emission tomography (PET) imaging as well as to improved hardware for producing such imaging agents is described. Flutemetamol (18F) Injection for the imaging of b amyloid plaques in the brain and methods and devices for preparing same are described including the automated synthesis and purification of [18F]flutemetamol by means of solid phase extraction (SPE).

摘要翻译： 描述了可用于正电子发射断层摄影（PET）成像以及用于生产这种成像剂的改进硬件的诊断成像剂。 描述了Flutemetamol（18F）用于脑中b淀粉样蛋白斑的成像的注射剂，以及用于制备其的方法和装置的注射剂，包括通过固相萃取（SPE）自动合成和纯化[18 F]氟美塔莫尔。

公开(公告)号：US20130012718A1

公开(公告)日：2013-01-10

申请号：US13517276

申请日：2010-10-08

申请人： Eric Horn ,  Steven Fairway ,  Dimitrios Mantzilas ,  Nigel Powell

发明人： Eric Horn ,  Steven Fairway ,  Dimitrios Mantzilas ,  Nigel Powell

IPC分类号： C07D277/66 ,  B01D15/26

CPC分类号： C07D277/66 ,  A61K51/0402 ,  B01D15/26 ,  C07B59/002 ,  C07B63/00 ,  C07B2200/05

摘要： A diagnostic imaging agent useful for positron emission tomography (PET) imaging as well as to improved hardware for producing such imaging agents is described. Flutemetamol (18F) Injection for the imaging of b amyloid plaques in the brain and methods and devices for preparing same are described including the automated synthesis and purification of [18F]flutemetamol by means of solid phase extraction (SPE).

摘要翻译： 描述了可用于正电子发射断层摄影（PET）成像以及用于生产这种成像剂的改进硬件的诊断成像剂。 描述了Flutemetamol（18F）用于脑中b淀粉样蛋白斑的成像的注射剂，以及用于制备其的方法和装置的注射剂，包括通过固相萃取（SPE）自动合成和纯化[18 F]氟美塔莫尔。

公开(公告)号：US07011619B1

公开(公告)日：2006-03-14

申请号：US09763006

申请日：1999-08-13

申请人： Dewi M. Lewis ,  Lucinda A. Dollimore ,  Nigel Powell ,  Gregory L. McIntire ,  Evan Gustow ,  Robert A. Snow

发明人： Dewi M. Lewis ,  Lucinda A. Dollimore ,  Nigel Powell ,  Gregory L. McIntire ,  Evan Gustow ,  Robert A. Snow

IPC分类号： A61N5/00

CPC分类号： A61N5/1027 ,  A61N2005/1023 ,  A61N2005/1025 ,  G21G4/08

摘要： The invention provides the use of a radiation source which is a low energy X-ray emitter, e.g. with an energy of emission of the principal photon in the range of 20 to 100 keV, preferably 20 to 40 keV and with a half life of 10 to 100 days, preferably 15 to 70 days, for the treatment of restenosis. Suitable radioisotopes include palladium-103, dysprosium-159, samarium-145, cadmium-109, ytterbium-169 and preferably iodine-125. High activity radioactive bodies and sources comprising such radioisotopes, and methods for the manufacture of such sources, are also disclosed.

公开(公告)号：US20060199991A1

公开(公告)日：2006-09-07

申请号：US11363844

申请日：2006-02-28

申请人： Dewi Lewis ,  Lucinda Dollimore ,  Nigel Powell ,  Gregory McIntire ,  Evan Gustow ,  Robert Snow

发明人： Dewi Lewis ,  Lucinda Dollimore ,  Nigel Powell ,  Gregory McIntire ,  Evan Gustow ,  Robert Snow

IPC分类号： A61N5/00

CPC分类号： A61N5/1027 ,  A61N2005/1023 ,  A61N2005/1025 ,  G21G4/08

摘要： The invention provides the use of a radiation source which is a low energy X-ray emitter, e.g. with an energy of emission of the principal photon in the range of 20 to 100 keV, preferably 20 to 40 keV and with a half life of 10 to 100 days, preferably 15 to 70 days, for the treatment of restenosis. Suitable radioisotopes include palladium-103, dysprosium-159, samarium-145, cadmium-109, ytterbium-169 and preferably iodine-125. High activity radioactive bodies and sources comprising such radioisotopes, and methods for the manufacture of such sources, are also disclosed.

摘要翻译： 本发明提供了一种辐射源的使用，该辐射源是低能X射线发射器，例如， 主要光子的发射能量在20至100keV，优选20至40keV的范围内，半衰期为10至100天，优选为15至70天，用于治疗再狭窄。 合适的放射性同位素包括钯-103，镝-159，钐-145，镉-109，镱-169，优选碘-125。 还公开了高活性放射性体和包含这种放射性同位素的来源，以及制造这种来源的方法。