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公开(公告)号：US20100322857A1
公开(公告)日：2010-12-23
申请号：US12517413
申请日：2007-12-11
申请人： Torgrim Engell , Steven Fairway , Ingrid Henriksen
发明人： Torgrim Engell , Steven Fairway , Ingrid Henriksen
CPC分类号： A61K51/08 , A61K51/088
摘要： The present invention relates to new radiolabelled peptide-based compounds and their use for diagnostic imaging using positron emission tomography (PET). Such compounds may thus be used for diagnosis or therapy of, for example, malignant diseases, heart diseases, endometriosis, inflammation-related diseases, rheumatoid arthritis and Kaposi's sarcoma.
摘要翻译： 本发明涉及新的放射性标记肽基化合物及其用于使用正电子发射断层摄影（PET）的诊断成像的用途。 因此，这样的化合物可用于诊断或治疗例如恶性疾病，心脏病，子宫内膜异位，炎症相关疾病，类风湿性关节炎和卡波西肉瘤。
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公开(公告)号：US08501153B2
公开(公告)日：2013-08-06
申请号：US12880218
申请日：2010-09-13
申请人： Radha Achanath , Srinath Balaji , Afsal M. Kadavilpparampu Mohamed , Umamaheshwar Mokkapati , Steven Fairway , Dimitrios Mantzilas , Dennis O'Shea , William John Trigg , Harry John Wadsworth , Joanna Marie Passmore , Bo Shan
发明人： Radha Achanath , Srinath Balaji , Afsal M. Kadavilpparampu Mohamed , Umamaheshwar Mokkapati , Steven Fairway , Dimitrios Mantzilas , Dennis O'Shea , William John Trigg , Harry John Wadsworth , Joanna Marie Passmore , Bo Shan
CPC分类号： C07D209/94 , A61K51/0446 , A61K51/0455 , A61K51/0468 , C07B59/002 , C07B2200/05 , C07D209/88 , C07D295/192 , C07D401/06 , C07D495/04
摘要： The present invention provides a PET tracer that has improved properties for imaging the peripheral benzodiazepine receptor (PBR) as compared with known such PET tracers. The present invention also provides a precursor compound useful in the preparation of the PET tracer of the invention and methods for the preparation of said precursor compound and said PET tracer. Also provided by the present invention is a radiopharmaceutical composition comprising the PET tracer of the invention. Methods for using the PET tracer and the radiopharmaceutical composition are also provided.
摘要翻译： 本发明提供了与已知的这种PET示踪剂相比具有改进的外周苯并二氮杂受体（PBR）成像的特性的PET示踪剂。 本发明还提供了可用于制备本发明的PET示踪剂的前体化合物和用于制备所述前体化合物和所述PET示踪剂的方法。 本发明还提供了包含本发明的PET示踪剂的放射性药物组合物。 还提供了使用PET示踪剂和放射性药物组合物的方法。
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公开(公告)号：US20110070161A1
公开(公告)日：2011-03-24
申请号：US12880218
申请日：2010-09-13
申请人： RADHA ACHANATH , SRINATH BALAJI , STEVEN FAIRWAY , AFSAL M. KADAVILPPARAMPU MOHAMED , DIMITRIOS MANTZILAS , UMAMAHESHWAR MOKKAPATI , DENNIS O'SHEA , JOANNA MARIE PASSMORE , BO SHAN , WILLIAM JOHN TRIGG , HARRY JOHN WADSWORTH
发明人： RADHA ACHANATH , SRINATH BALAJI , STEVEN FAIRWAY , AFSAL M. KADAVILPPARAMPU MOHAMED , DIMITRIOS MANTZILAS , UMAMAHESHWAR MOKKAPATI , DENNIS O'SHEA , JOANNA MARIE PASSMORE , BO SHAN , WILLIAM JOHN TRIGG , HARRY JOHN WADSWORTH
IPC分类号： A61K51/04 , C07D209/88 , B01J19/00
CPC分类号： C07D209/94 , A61K51/0446 , A61K51/0455 , A61K51/0468 , C07B59/002 , C07B2200/05 , C07D209/88 , C07D295/192 , C07D401/06 , C07D495/04
摘要： The present invention provides a PET tracer that has improved properties for imaging the peripheral benzodiazepine receptor (PBR) as compared with known such PET tracers. The present invention also provides a precursor compound useful in the preparation of the PET tracer of the invention and methods for the preparation of said precursor compound and said PET tracer. Also provided by the present invention is a radiopharmaceutical composition comprising the PET tracer of the invention. Methods for using the PET tracer and the radiopharmaceutical composition are also provided.
摘要翻译： 本发明提供了与已知的这种PET示踪剂相比具有改进的外周苯并二氮杂受体（PBR）成像的特性的PET示踪剂。 本发明还提供了可用于制备本发明的PET示踪剂的前体化合物和用于制备所述前体化合物和所述PET示踪剂的方法。 本发明还提供了包含本发明的PET示踪剂的放射性药物组合物。 还提供了使用PET示踪剂和放射性药物组合物的方法。
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公开(公告)号：US08969580B2
公开(公告)日：2015-03-03
申请号：US13517276
申请日：2010-10-08
申请人： Eric Horn , Steven Fairway , Dimitrios Mantzilas , Nigel Powell
发明人： Eric Horn , Steven Fairway , Dimitrios Mantzilas , Nigel Powell
IPC分类号： C07D277/66 , A61K51/04 , C07B59/00 , C07B63/00
CPC分类号： C07D277/66 , A61K51/0402 , B01D15/26 , C07B59/002 , C07B63/00 , C07B2200/05
摘要： A diagnostic imaging agent useful for positron emission tomography (PET) imaging as well as to improved hardware for producing such imaging agents is described. Flutemetamol (18F) Injection for the imaging of b amyloid plaques in the brain and methods and devices for preparing same are described including the automated synthesis and purification of [18F]flutemetamol by means of solid phase extraction (SPE).
摘要翻译： 描述了可用于正电子发射断层摄影（PET）成像以及用于生产这种成像剂的改进硬件的诊断成像剂。 描述了Flutemetamol（18F）用于脑中b淀粉样蛋白斑的成像的注射剂，以及用于制备其的方法和装置的注射剂，包括通过固相萃取（SPE）自动合成和纯化[18 F]氟美塔莫尔。
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公开(公告)号：US20130012718A1
公开(公告)日：2013-01-10
申请号：US13517276
申请日：2010-10-08
申请人： Eric Horn , Steven Fairway , Dimitrios Mantzilas , Nigel Powell
发明人： Eric Horn , Steven Fairway , Dimitrios Mantzilas , Nigel Powell
IPC分类号： C07D277/66 , B01D15/26
CPC分类号： C07D277/66 , A61K51/0402 , B01D15/26 , C07B59/002 , C07B63/00 , C07B2200/05
摘要： A diagnostic imaging agent useful for positron emission tomography (PET) imaging as well as to improved hardware for producing such imaging agents is described. Flutemetamol (18F) Injection for the imaging of b amyloid plaques in the brain and methods and devices for preparing same are described including the automated synthesis and purification of [18F]flutemetamol by means of solid phase extraction (SPE).
摘要翻译： 描述了可用于正电子发射断层摄影（PET）成像以及用于生产这种成像剂的改进硬件的诊断成像剂。 描述了Flutemetamol（18F）用于脑中b淀粉样蛋白斑的成像的注射剂，以及用于制备其的方法和装置的注射剂，包括通过固相萃取（SPE）自动合成和纯化[18 F]氟美塔莫尔。
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