Degradable polymers
    3.
    发明申请
    Degradable polymers 审中-公开
    可降解聚合物

    公开(公告)号:US20070155926A1

    公开(公告)日:2007-07-05

    申请号:US10548354

    申请日:2004-03-29

    IPC分类号: C08F120/00

    摘要: Polymers comprising a polymer backbone comprising one or more degradable units are described. The polymer may additionally comprise two or more polymer segments comprising radically (co)polymerizable vinyl monomer units. The degradable units may be independently selected from, but not limited to, at least one of hydrodegradable, photodegradable and biodegradable units between the polymer segments and dispersed along the polymer backbone. The degradable units may be derived from one or more monomers comprising a heterocyclic ring that is capable of undergoing radical ring opening polymerization, a coupling agent, or from a polymerization initiator, radically polymerizable monomers, as well as other reactive sources. Embodiments of the degradable polymer of claim are capable of degrading by at least one of a hydrodegradation, photodegradation or biodegradation mechanisms to form at least one of telechelic oligomer and telechelic polymeric fragments of the polymer. The degradable polymer may be able to degrade into polymer fragments having a molecular weight distribution of less than 5, or in certain applications it may be preferable for embodiments of the polymer to be capable of forming polymer fragments having a molecular weight distribution of the polymer fragments less than 3.0 or even less than 2.5. Embodiments of the present invention also include methods of producing degradable polymers.

    摘要翻译: 描述了包含包含一个或多个可降解单元的聚合物主链的聚合物。 聚合物可以另外包含两个或更多个包含自由基(共)可聚合的乙烯基单体单元的聚合物链段。 可降解单元可以独立地选自但不限于聚合物链段之间的可分解降解的,可光降解的和可生物降解的单元中的至少一种,并沿着聚合物主链分散。 可降解单元可以衍生自一种或多种包含能够进行自由基开环聚合的杂环,偶联剂或聚合引发剂,可自由基聚合的单体以及其它反应性源的单体。 权利要求中的可降解聚合物的实施方案能够通过加氢降解,光降解或生物降解机理中的至少一种降解以形成聚合物的遥爪低聚物和遥爪聚合物片段中的至少一种。 可降解聚合物可能能够降解为具有小于5的分子量分布的聚合物片段,或者在某些应用中,聚合物的实施方案可优选地形成具有聚合物片段的分子量分布的聚合物片段 小于3.0或甚至小于2.5。 本发明的实施方案还包括生产可降解聚合物的方法。