公开(公告)号：US07569683B2

公开(公告)日：2009-08-04

申请号：US12044818

申请日：2008-03-07

申请人： Eric J. Hansen ,  Christoph Aebi ,  Leslie D. Cope ,  Isobel Maciver ,  Michael J. Fiske ,  Ross A. Fredenburg

发明人： Eric J. Hansen ,  Christoph Aebi ,  Leslie D. Cope ,  Isobel Maciver ,  Michael J. Fiske ,  Ross A. Fredenburg

IPC分类号： C07H21/04

CPC分类号： C07K14/212 ,  A61K39/00 ,  C07K16/1217

摘要： The present invention discloses the existence of two novel proteins UspA1 and UspA2, and their respective genes uspA1 and uspA2. Each protein encompasses a region that is conserved between the two proteins and comprises an epitope that is recognized by the MAb 17C7. One or more than one of these species may aggregate to form the very high molecular weight form (i.e. greater than 200 kDa) of the UspA antigen. Compositions and both diagnostic and therapeutic methods for the treatment and study of M. catarrhalis are disclosed.

摘要翻译： 本发明公开了两种新型蛋白质UspA1和UspA2及其各自的基因uspA1和uspA2的存在。 每个蛋白质包含在两种蛋白质之间保守的区域，并且包含由MAb 17C7识别的表位。 这些物质中的一种或多于一种可能聚集形成UspA抗原的非常高分子量形式（即大于200kDa）。 公开了组合物以及用于治疗和研究卡他莫拉菌的诊断和治疗方法。

公开(公告)号：US06753417B2

公开(公告)日：2004-06-22

申请号：US09952267

申请日：2001-09-12

申请人： Eric J. Hansen ,  Christoph Aebi ,  Leslie D. Cope ,  Isobel Maciver ,  Michael J. Fiske ,  Ross A. Fredenburg

发明人： Eric J. Hansen ,  Christoph Aebi ,  Leslie D. Cope ,  Isobel Maciver ,  Michael J. Fiske ,  Ross A. Fredenburg

IPC分类号： C07H2104

CPC分类号： C07K14/212 ,  A61K39/00 ,  C07K16/1217

摘要： The present invention discloses the existence of two novel proteins UspA1 and UspA2, and their respective genes uspA1 and uspA2. Each protein encompasses a region that is conserved between the two proteins and comprises an epitope that is recognized by the MAb 17C7. One or more than one of these species may aggregate to form the very high molecular weight form (i.e. greater than 200 kDa) of the UspA antigen. Compositions and both diagnostic and therapeutic methods for the treatment and study of M. catarrhalis are disclosed.

摘要翻译： 本发明公开了两种新型蛋白质UspA1和UspA2及其各自的基因uspA1和uspA2的存在。 每个蛋白质包含在两种蛋白质之间保守的区域，并且包含由MAb 17C7识别的表位。 这些物质中的一种或多于一种可能聚集形成UspA抗原的非常高分子量形式（即大于200kDa）。 公开了组合物以及用于治疗和研究卡他莫拉菌的诊断和治疗方法。

公开(公告)号：US06310190B1

公开(公告)日：2001-10-30

申请号：US09336447

申请日：1999-06-21

申请人： Eric J. Hansen ,  Christoph Aebi ,  Leslie D. Cope ,  Isobel Maciver ,  Michael J. Fiske ,  Ross A. Fredenburg

发明人： Eric J. Hansen ,  Christoph Aebi ,  Leslie D. Cope ,  Isobel Maciver ,  Michael J. Fiske ,  Ross A. Fredenburg

IPC分类号： C07H2104

CPC分类号： C07K14/212 ,  A61K39/00 ,  C07K16/1217

摘要： The present invention discloses the existence of two novel proteins UspA1 and UspA2, and their respective genes uspA1 and uspA2. Each protein encompasses a region that is conserved between the two proteins and comprises an epitope that is recognized by the MAb 17C7. One or more than one of these species may aggregate to form the very high molecular weight form (i.e. greater than 200 kDa) of the UspA antigen. Compositions and both diagnostic and therapeutic methods for the treatment and study of M. catarrhalis are disclosed.

摘要翻译： 本发明公开了两种新型蛋白质UspA1和UspA2及其各自的基因uspA1和uspA2的存在。 每个蛋白质包含在两种蛋白质之间保守的区域，并且包含由MAb 17C7识别的表位。 这些物质中的一种或多于一种可能聚集形成UspA抗原的非常高分子量形式（即大于200kDa）。 公开了组合物以及用于治疗和研究卡他莫拉菌的诊断和治疗方法。

公开(公告)号：US20090118486A1

公开(公告)日：2009-05-07

申请号：US12044805

申请日：2008-03-07

申请人： ERIC J. HANSEN ,  Christoph Aebi ,  Leslie D. Cope ,  Isobel Maciver ,  Michael J. Fiske ,  Ross A. Fredenburg

发明人： ERIC J. HANSEN ,  Christoph Aebi ,  Leslie D. Cope ,  Isobel Maciver ,  Michael J. Fiske ,  Ross A. Fredenburg

IPC分类号： C07H21/00

CPC分类号： C07K14/212 ,  A61K39/00 ,  C07K16/1217

摘要： The present invention discloses the existence of two novel proteins UspA1 and UspA2, and their respective genes uspA1 and uspA2. Each protein encompasses a region that is conserved between the two proteins and comprises an epitope that is recognized by the MAb 17C7. One or more than one of these species may aggregate to form the very high molecular weight form (i.e. greater than 200 kDa) of the UspA antigen. Compositions and both diagnostic and therapeutic methods for the treatment and study of M. catarrhalis are disclosed.

公开(公告)号：US07344724B2

公开(公告)日：2008-03-18

申请号：US10872769

申请日：2004-06-21

申请人： Eric J. Hansen ,  Christoph Aebi ,  Leslie D. Cope ,  Isobel Maciver ,  Michael J. Fiske ,  Ross A. Fredenburg

发明人： Eric J. Hansen ,  Christoph Aebi ,  Leslie D. Cope ,  Isobel Maciver ,  Michael J. Fiske ,  Ross A. Fredenburg

IPC分类号： A61K39/02

CPC分类号： C07K14/212 ,  A61K39/00 ,  C07K16/1217

摘要： The present invention discloses the existence of two novel proteins UspA1 and UspA2, and their respective genes uspA1 and uspA2. Each protein encompasses a region that is conserved between the two proteins and comprises an epitope that is recognized by the MAb 17C7. One or more than one of these species may aggregate to form the very high molecular weight form (i.e. greater than 200 kDa) of the UspA antigen. Compositions and both diagnostic and therapeutic methods for the treatment and study of M. catarrhalis are disclosed.

摘要翻译： 本发明公开了两种新型蛋白质UspA1和UspA2及其各自的基因uspA1和uspA2的存在。 每个蛋白质包含在两种蛋白质之间保守的区域，并且包含由MAb 17C7识别的表位。 这些物质中的一种或多于一种可以聚集形成UspA抗原的非常高分子量形式（即大于200kDa）。 公开了组合物以及用于治疗和研究卡他莫拉菌的诊断和治疗方法。

公开(公告)号：US07288646B2

公开(公告)日：2007-10-30

申请号：US10872768

申请日：2004-06-21

申请人： Eric J. Hansen ,  Christoph Aebi ,  Leslie D. Cope ,  Isobel Maciver ,  Michael J. Fiske ,  Ross A. Fredenburg

发明人： Eric J. Hansen ,  Christoph Aebi ,  Leslie D. Cope ,  Isobel Maciver ,  Michael J. Fiske ,  Ross A. Fredenburg

IPC分类号： C07H21/04

CPC分类号： C07K14/212 ,  A61K39/00 ,  C07K16/1217

摘要： The present invention discloses the existence of two novel proteins UspA1 and UspA2, and their respective genes uspA1 and uspA2. Each protein encompasses a region that is conserved between the two proteins and comprises an epitope that is recognized by the MAb 17C7. One or more than one of these species may aggregate to form the very high molecular weight form (ie. greater than 200 kDa) of the UspA antigen. Compositions and both diagnostic and therapeutic methods for the treatment and study of M catarrhalis are disclosed.

摘要翻译： 本发明公开了两种新型蛋白质UspA1和UspA2及其各自的基因uspA1和uspA2的存在。 每个蛋白质包含在两种蛋白质之间保守的区域，并且包含由MAb 17C7识别的表位。 这些物质中的一种或多于一种可能聚集形成UspA抗原的非常高分子量形式（即大于200kDa）。 公开了治疗和研究卡他莫拉胶囊的组合物和诊断和治疗方法。

公开(公告)号：US07576194B2

公开(公告)日：2009-08-18

申请号：US12044805

申请日：2008-03-07

申请人： Eric J. Hansen ,  Christoph Aebi ,  Leslie D. Cope ,  Isobel Maciver ,  Michael J. Fiske ,  Ross A. Fredenburg

发明人： Eric J. Hansen ,  Christoph Aebi ,  Leslie D. Cope ,  Isobel Maciver ,  Michael J. Fiske ,  Ross A. Fredenburg

IPC分类号： C07H21/04

CPC分类号： C07K14/212 ,  A61K39/00 ,  C07K16/1217

摘要： The present invention discloses the existence of two novel proteins UspA1 and UspA2, and their respective genes uspA1 and uspA2. Each protein encompasses a region that is conserved between the two proteins and comprises an epitope that is recognized by the MAb 17C7. One or more than one of these species may aggregate to form the very high molecular weight form (i.e. greater than 200 kDa) of the UspA antigen. Compositions and both diagnostic and therapeutic methods for the treatment and study of M. catarrhalis are disclosed.

摘要翻译： 本发明公开了两种新型蛋白质UspA1和UspA2及其各自的基因uspA1和uspA2的存在。 每个蛋白质包含在两种蛋白质之间保守的区域，并且包含由MAb 17C7识别的表位。 这些物质中的一种或多于一种可能聚集形成UspA抗原的非常高分子量形式（即大于200kDa）。 公开了组合物以及用于治疗和研究卡他莫拉菌的诊断和治疗方法。

公开(公告)号：US20090137788A1

公开(公告)日：2009-05-28

申请号：US12044818

申请日：2008-03-07

申请人： ERIC J. HANSEN ,  Christoph Aebi ,  Leslie D. Cope ,  Isobel Maciver ,  Michael J. Fiske ,  Ross A. Fredenburg

发明人： ERIC J. HANSEN ,  Christoph Aebi ,  Leslie D. Cope ,  Isobel Maciver ,  Michael J. Fiske ,  Ross A. Fredenburg

IPC分类号： C07H21/00

CPC分类号： C07K14/212 ,  A61K39/00 ,  C07K16/1217

摘要： The present invention discloses the existence of two novel proteins UspA1 and UspA2, and their respective genes uspA1 and uspA2. Each protein encompasses a region that is conserved between the two proteins and comprises an epitope that is recognized by the MAb 17C7. One or more than one of these species may aggregate to form the very high molecular weight form (i.e. greater than 200 kDa) of the UspA antigen. Compositions and both diagnostic and therapeutic methods for the treatment and study of M. catarrhalis are disclosed.

摘要翻译： 本发明公开了两种新型蛋白质UspA1和UspA2及其各自的基因uspA1和uspA2的存在。 每个蛋白质包含在两种蛋白质之间保守的区域，并且包含由MAb 17C7识别的表位。 这些物质中的一种或多于一种可能聚集形成UspA抗原的非常高分子量形式（即大于200kDa）。 公开了组合物以及用于治疗和研究卡他莫拉菌的诊断和治疗方法。

公开(公告)号：US20090253655A1

公开(公告)日：2009-10-08

申请号：US12402910

申请日：2009-03-12

申请人： Peter T. Lansbury, JR. ,  Craig J. Justman ,  Ross A. Fredenburg ,  Robin Kate Meray ,  Mark E. Duggan ,  Peter Lin

发明人： Peter T. Lansbury, JR. ,  Craig J. Justman ,  Ross A. Fredenburg ,  Robin Kate Meray ,  Mark E. Duggan ,  Peter Lin

IPC分类号： A61K31/675 ,  C12N5/02 ,  A61K31/47 ,  C07F9/06 ,  C07D215/00 ,  C07D401/02 ,  C07D409/04 ,  C07D401/14

CPC分类号： C07F9/65583 ,  C07D215/36 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D409/14

摘要： Novel quinolinone farnesyl transferase inhibitors are provided. These new compounds are useful in the treatment or prevention of synucleinopathies, such as Parkinson's Disease, Diffuse Lewy Body Disease, multiple system atrophy, and disorders of brain iron concentration including pantothenate kinase-associated neurodegeneration (e.g., PANK1), or other neurodegenerative/neurological diseases. Provided compounds are also useful in the treatment of proliferative diseases such as cancer, and in the treatment of neurological diseases, such as cognitive impairment, depression, and anxiety.The treatment including administering to a subject a therapeutically effective amount of an inventive farnesyl transferase inhibitor compound.

摘要翻译： 提供了新的喹啉酮法呢基转移酶抑制剂。 这些新化合物可用于治疗或预防突触核蛋白病，如帕金森病，弥漫性路易体病，多系统萎缩，脑铁浓度紊乱，包括泛酸激酶相关神经变性（如PANK1）或其他神经变性/神经系统疾病 疾病 提供的化合物也可用于治疗增殖性疾病如癌症，以及治疗诸如认知障碍，抑郁和焦虑的神经疾病。 治疗包括向受试者施用治疗有效量的本发明的法呢基转移酶抑制剂化合物。

公开(公告)号：US08232402B2

公开(公告)日：2012-07-31

申请号：US12402910

申请日：2009-03-12

申请人： Peter T. Lansbury, Jr. ,  Craig J. Justman ,  Ross A. Fredenburg ,  Robin Kate Meray ,  Mark E. Duggan ,  Peter Lin

发明人： Peter T. Lansbury, Jr. ,  Craig J. Justman ,  Ross A. Fredenburg ,  Robin Kate Meray ,  Mark E. Duggan ,  Peter Lin

IPC分类号： C07D215/38 ,  A61K31/04

CPC分类号： C07F9/65583 ,  C07D215/36 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D409/14

摘要： Novel quinolinone farnesyl transferase inhibitors are provided. These new compounds are useful in the treatment or prevention of synucleinopathies, such as Parkinson's Disease, Diffuse Lewy Body Disease, multiple system atrophy, and disorders of brain iron concentration including pantothenate kinase-associated neurodegeneration (e.g., PANK1), or other neurodegenerative/neurological diseases. Provided compounds are also useful in the treatment of proliferative diseases such as cancer, and in the treatment of neurological diseases, such as cognitive impairment, depression, and anxiety. The treatment including administering to a subject a therapeutically effective amount of an inventive farnesyl transferase inhibitor compound.

摘要翻译： 提供了新的喹啉酮法呢基转移酶抑制剂。 这些新化合物可用于治疗或预防突触核蛋白病，如帕金森病，弥漫性路易体病，多系统萎缩，脑铁浓度紊乱，包括泛酸激酶相关神经变性（如PANK1）或其他神经变性/神经系统疾病 疾病 提供的化合物也可用于治疗增殖性疾病如癌症，以及治疗诸如认知障碍，抑郁和焦虑的神经疾病。 治疗包括向受试者施用治疗有效量的本发明的法呢基转移酶抑制剂化合物。