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公开(公告)号：US06490488B1
公开(公告)日：2002-12-03
申请号：US09552905
申请日：2000-04-20
IPC分类号： B61N502
CPC分类号： A61B18/1815 , A61B2017/00084 , A61B2017/00274 , A61B2018/00023 , A61B2018/00547
摘要： A thermal therapy method includes inserting an applicator including an energy-emitting device into a body cavity such as a urethra adjacent a targeted tissue region such as a prostate, energizing the energy-emitting device, and circulating coolant between the energy-emitting device and a wall of the body cavity. The therapy is controlled by decreasing a temperature of the coolant and continually adjusting coolant temperature based on therapy parameters. The applicator, or selected tissue at a predetermined depth from the wall of the body cavity, is maintained at a temperature corresponding to a predetermined applicator temperature profile by adjusting a power level provided to the energy-emitting device. In one embodiment involving treatment of the prostate, rectal temperature is monitored and, upon sensing a rectal temperature that exceeds a predetermined threshold, the temperature of the coolant is increased to force a reduction in power provided to the energy-emitting device to maintain the applicator at the temperature corresponding to the predetermined applicator temperature profile.
摘要翻译： 一种热疗法包括将包括能量发射装置的施放器插入诸如前列腺等目标组织区域的体腔内的尿道内，激发能量发射装置，以及将能量发射装置和 体腔壁。 该治疗通过降低冷却剂的温度并基于治疗参数连续地调节冷却剂温度来控制。 通过调节提供给能量发射装置的功率水平，将施加器或在体腔壁的预定深度处的选定组织保持在与预定的施用器温度分布相对应的温度。 在涉及治疗前列腺的一个实施方案中，监测直肠温度，并且在检测到超过预定阈值的直肠温度时，增加冷却剂的温度以迫使提供给能量发射装置的功率降低以维持施用器 在对应于预定施加器温度曲线的温度下。
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公开(公告)号：US5413588A
公开(公告)日：1995-05-09
申请号：US847718
申请日：1992-03-06
CPC分类号： A61B18/18 , A61B18/1815 , A61N5/02 , A61N5/04 , A61N5/045 , A61B2017/00274 , A61B2018/00547 , A61M25/10
摘要： An intraurethral, Foley-type catheter shaft contains a microwave antenna capable of generating a cylindrically symmetrical thermal pattern, within which temperatures are capable of exceeding 45.degree. C. The antenna, which is positioned within the shaft, is surrounded by means within the shaft for absorbing thermal energy conducted by the tissue and asymmetrically absorbing electromagnetic energy emitted by the antenna--a greater amount of electromagnetic energy being absorbed on one side of the shaft. This asymmetrical absorption alters the thermal pattern generated by the microwave antenna, making it cylindrically asymmetrical, which effectively focuses microwave thermal therapy toward undesirous benign tumorous tissue growth of a prostate anterior and lateral to the urethra, and away from healthy tissue posterior to the urethra.
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3.发明授权
公开(公告)号：US5370677A
公开(公告)日：1994-12-06
申请号：US123321
申请日：1993-09-17
申请人： Eric N. Rudie , Stanley E. Kluge
发明人： Eric N. Rudie , Stanley E. Kluge
CPC分类号： A61B18/1815 , A61B18/18 , A61N5/02 , A61N5/045 , A61B2018/00523
摘要： A catheter shaft carries a coaxial cable, the terminal end of which contains a dipole antenna with opposing first and second helical elements. The first and second helical elements originate from a common connection to an outer conductor of the coaxial cable. The first and second helical elements are formed by winding flat wire around an outer insulator of the coaxial cable near a terminal end of the coaxial cable. A tubular-shaped capacitor is connected between an inner conductor of the coaxial cable and a point on the second helical element where the resistive component of the antenna's impedance matches the characteristic impedance of the coaxial cable. This match minimizes reflective losses of the antenna, thereby maximizing power transfer to the antenna. The antenna has an effective electrical length which is equal to one half the wavelength of the radiation emitted, independent of the physical length of the antenna. The antenna also has a radiation length which can be adjusted by varying the number and pitch of turns of the flat wire and the location of the impedance matching point.
摘要翻译： 导管轴携带同轴电缆，其同轴电缆的末端包含具有相对的第一和第二螺旋元件的偶极天线。 第一和第二螺旋元件源自与同轴电缆的外部导体的公共连接。 第一和第二螺旋元件通过在同轴电缆的末端附近绕着同轴电缆的外绝缘体缠绕扁线而形成。 管状电容器连接在同轴电缆的内部导体和第二螺旋元件上的点之间，其中天线阻抗的电阻分量与同轴电缆的特性阻抗匹配。 该匹配使天线的反射损耗最小化，从而最大化对天线的功率传输。 天线具有等于辐射发射波长的一半的有效电长度，与天线的物理长度无关。 该天线还具有可以通过改变扁平线的匝数和间距以及阻抗匹配点的位置来调整的辐射长度。
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公开(公告)号：US20080039897A1
公开(公告)日：2008-02-14
申请号：US11836592
申请日：2007-08-09
CPC分类号： A61B5/0215 , A61N1/057 , A61N1/3627 , A61N1/36564
摘要： A pressure sensing device includes a body portion, a pressure transmitting port, and an electrical lead. The body portion includes transducing electronics within a housing that is shaped about a longitudinal axis. The housing has a coating thereon that promotes tissue growth to anchor the housing within a ventricular septum. The pressure transmitting port is located at a distal longitudinal end of the body portion such that a ventricle pressure being sensed is transmitted through the port and to the transducing electronics when the body portion is anchored in the ventricular septum. The electrical lead is connected to the transducing electronics and exits from a proximal longitudinal end of the body portion.
摘要翻译： 压力感测装置包括主体部分，压力传递端口和电引线。 主体部分包括围绕纵向轴线成形的壳体内的换能器。 外壳在其上具有促进组织生长以将壳体锚定在心室隔膜内的涂层。 压力传递端口位于主体部分的远端纵向端部处，使得当身体部分锚定在心室隔膜中时，感测的心室压力通过端口传递到换能电子装置。 电引线连接到换能电子装置并从主体部分的近端纵向端部离开。
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5.发明授权Device and method for asymmetrical thermal therapy with helical dipole microwave antenna 失效用螺旋偶极微波天线进行非对称热疗的装置和方法
公开(公告)号：US5916241A
公开(公告)日：1999-06-29
申请号：US903051
申请日：1997-07-30
CPC分类号： A61B18/18 , A61B18/1815 , A61N5/02 , A61N5/04 , A61N5/045 , A61B2017/00274 , A61B2018/00547 , A61M25/10
摘要： An intraurethral, Foley-type catheter shaft contains a microwave antenna capable of generating a cylindrically symmetrical thermal pattern, within which temperatures are capable of exceeding 45.degree. C. The antenna, which is positioned within the shaft, is surrounded by means within the shaft for absorbing thermal energy conducted by the tissue and asymmetrically absorbing electromagnetic energy emitted by the antenna--a greater amount of electromagnetic energy being absorbed on one side of the shafts. This asymmetrical absorption alters the thermal pattern generated by the microwave antenna, making it cylindrically asymmetrical, which effectively focuses microwave thermal therapy toward undesirous benign tumorous tissue growth of a prostate anterior and lateral to the urethra, and away from healthy tissue posterior to the urethra.
摘要翻译： 尿道内的Foley型导管轴包含能够产生圆柱形对称热图案的微波天线，其中温度可以超过45℃。定位在轴内的天线由轴内的装置包围， 吸收由组织传导的热能并且不对称地吸收由天线发射的电磁能量 - 在轴的一侧上吸收更多量的电磁能。 这种不对称吸收改变了由微波天线产生的热图，使其成圆柱形不对称，这有效地将微波热治疗聚焦到尿道前列腺前列腺前列腺前列腺良性肿瘤组织生长，远离尿道后方的健康组织。
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公开(公告)号：US5899932A
公开(公告)日：1999-05-04
申请号：US824064
申请日：1997-03-24
CPC分类号： A61B18/1815 , A61B18/18 , A61B2017/00101 , A61B2017/00274 , A61B2018/00023 , A61B2018/00547 , A61B2018/1861
摘要： A method of prostate treatment includes the step of inserting into a prostatic portion of urethra an energy emitting device that is connected to an energy source. Energy is delivered to the prostate from the energy emitting device. The amount of energy emitted to prostatic tissue adjacent to a bladder is greater than that emitted to prostatic tissue distant from the bladder.
摘要翻译： 前列腺治疗的方法包括将连接到能量源的能量发射装置插入尿道前列腺部分的步骤。 能量从能量发射装置输送到前列腺。 发射到邻近膀胱的前列腺组织的能量大于远离膀胱的前列腺组织的能量。
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公开(公告)号：US5843144A
公开(公告)日：1998-12-01
申请号：US494320
申请日：1995-06-26
申请人： Eric N. Rudie , Mitchell Dann , John M. Reid , Bruce H. Neilson , James V. Kauphusman , James E. Burgett , Stanley E. Kluge , Steven W. Norsted
发明人： Eric N. Rudie , Mitchell Dann , John M. Reid , Bruce H. Neilson , James V. Kauphusman , James E. Burgett , Stanley E. Kluge , Steven W. Norsted
CPC分类号： A61B18/1815 , A61B18/18
摘要： A method for treating an individual with diseased prostatic tissue, such as benign prostatic hyperplasia, includes inserting a catheter into a urethra to position a microwave antenna located within the catheter adjacent a prostatic region of the urethra. A microwave antenna is then driven within a power range for applying microwave energy substantially continuously to prostatic tissue to heat the prostatic tissue surrounding the microwave antenna at a temperature and for a time period sufficient to cause necrosis of the prostatic tissue.
摘要翻译： 用于治疗具有患病前列腺组织（例如良性前列腺增生）的个体的方法包括将导管插入尿道以将位于尿道前列腺区域附近的微波天线定位。 然后在功率范围内驱动微波天线，以将微波能量基本连续地施加到前列腺组织，以在足以引起前列腺组织坏死的温度和时间段加热微波天线周围的前列腺组织。
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8.发明授权Device and method for asymmetrical thermal therapy with helical dipole microwave antenna 失效用螺旋偶极微波天线进行非对称热疗的装置和方法
公开(公告)号：US5464445A
公开(公告)日：1995-11-07
申请号：US208642
申请日：1994-03-09
CPC分类号： A61B18/18 , A61B18/1815 , A61N5/02 , A61N5/04 , A61N5/045 , A61B2017/00274 , A61B2018/00547 , A61M25/10
摘要： An intraurethral, Foley-type catheter shaft contains a microwave antenna capable of generating a cylindrically symmetrical thermal pattern, within which temperatures are capable of exceeding 45.degree. C. The antenna, which is positioned within the shaft, is surrounded by means within the shaft for absorbing thermal energy conducted by the tissue and asymmetrically absorbing electromagnetic energy emitted by the antenna--a greater amount of electromagnetic energy being absorbed on one side of the shaft. This asymmetrical absorption alters the thermal pattern generated by the microwave antenna, making it cylindrically asymmetrical, which effectively focuses microwave thermal therapy toward undesirous benign tumorous tissue growth of a prostate anterior and lateral to the urethra, and away from healthy tissue posterior to the urethra.
摘要翻译： 尿道内的Foley型导管轴包含能够产生圆柱形对称热图案的微波天线，其中温度可以超过45℃。定位在轴内的天线由轴内的装置包围， 吸收由组织传导的热能并且不对称地吸收天线发射的电磁能量 - 在轴的一侧上吸收更大量的电磁能。 这种不对称吸收改变了由微波天线产生的热图，使其成圆柱形不对称，这有效地将微波热治疗聚焦到尿道前列腺前列腺前列腺前列腺良性肿瘤组织生长，远离尿道后方的健康组织。
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公开(公告)号：US06312391B1
公开(公告)日：2001-11-06
申请号：US09505587
申请日：2000-02-16
IPC分类号： A61B500
CPC分类号： A61B5/4375 , A61B5/015 , A61B2017/00274 , A61B2018/00547 , A61N5/04
摘要： A non-invasive method of determining a temperature distribution in a targeted tissue volume treated with thermal therapy involves determining a baseline perfusion characteristic of the targeted tissue volume. A temperature distribution is calculated in the targeted tissue volume based on the baseline perfusion characteristic of the tissue, a microwave power input and a coolant temperature input. A perfusion characteristic of the targeted tissue volume is iteratively adjusted based on the calculated temperature distribution, and the temperature distribution is iteratively recalculated based on the adjusted perfusion characteristic, the microwave power input and the coolant temperature input throughout the thermal therapy.
摘要翻译： 确定用热疗法治疗的靶组织体积中的温度分布的非侵入性方法包括确定靶组织体积的基线灌注特征。 基于组织的基线灌注特性，微波功率输入和冷却剂温度输入，在目标组织体积中计算温度分布。 基于计算的温度分布迭代地调整目标组织体积的灌注特性，并且基于经整个热治疗的调整灌注特性，微波功率输入和冷却剂温度输入，迭代地重新计算温度分布。
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公开(公告)号：US06223085B1
公开(公告)日：2001-04-24
申请号：US08852154
申请日：1997-05-06
申请人： Mitchell Dann , Scott P. Thome , Jonathan R. McGrath , Eric N. Rudie , Jonathan L. Flachman , Teruo T. Hirose
发明人： Mitchell Dann , Scott P. Thome , Jonathan R. McGrath , Eric N. Rudie , Jonathan L. Flachman , Teruo T. Hirose
IPC分类号： A61B1736
CPC分类号： A61B18/18 , A61B18/1492 , A61B18/1815 , A61B2017/22002 , A61B2017/22038 , A61B2017/22067 , A61B2018/00023 , A61B2018/00214 , A61B2018/00369 , A61B2018/00422 , A61B2018/1435 , A61B2018/183 , A61B2018/1838 , A61B2018/1846 , A61B2018/1861 , A61N5/045
摘要： A method and apparatus for reducing restenosis of a stenotic region of a blood vessel after performing a dilatation angioplasty treatment is disclosed. The method includes radiating microwave energy from a microwave antenna to kill a medial tissue layer of the blood vessel in the stenotic region. The radiation is applied during or after inflation of dilatation balloon to permanently dilate the stenotic region. When radiation is applied during dilatation of the stenotic region, the dilatation balloon forms a seal against the inner wall surface of the blood vessel to exclude blood in the vessel from contacting the stenotic region. The method preferably further includes cooling the blood circulating in the blood vessel about a shaft of the catheter with cooling fluid circulating within cooling lumens of the catheter and cooling an inner wall surface of the blood vessel in the stenotic region during the application of radiation to the medial cell layer. Finally, the method also preferably includes perfusing blood in the vessel through the catheter across the stenotic region during dilatation of the stenotic region to maintain circulation of blood through the blood vessel during the dilatation of the stenotic region.
摘要翻译： 公开了一种用于在进行扩张血管成形术治疗后减少血管狭窄区域的再狭窄的方法和装置。 该方法包括从微波天线辐射微波能量以杀死狭窄区域中血管的内侧组织层。 在膨胀气球充气期间或之后施加辐射以永久扩张狭窄区域。 当在狭窄区域的扩张期间施加辐射时，扩张气囊对血管的内壁表面形成密封，以排除血管中的血液与狭窄区域接触。 该方法优选还包括：在导管冷却腔内循环的冷却流体冷却在血管周围的血液循环的血液，并且在将辐射施加到第二导管的过程中冷却狭窄区域中血管的内壁表面 内侧细胞层。 最后，该方法还优选包括在狭窄区域的扩张期间通过穿过狭窄区域的导管在血管中灌注血液，以在狭窄区域的扩张期间维持血液通过血管的循环。
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