公开(公告)号：US20050124667A1

公开(公告)日：2005-06-09

申请号：US10969480

申请日：2004-10-20

申请人： Eric Sartori ,  Magali Maillet ,  Marie Paugam ,  Eric Nicolai ,  Michael Lawrence ,  Karnail Atwal

发明人： Eric Sartori ,  Magali Maillet ,  Marie Paugam ,  Eric Nicolai ,  Michael Lawrence ,  Karnail Atwal

IPC分类号： A61K31/165 ,  A61K31/277 ,  A61K31/325 ,  A61K31/4172 ,  A61K31/455

CPC分类号： A61K31/165 ,  A61K31/277 ,  A61K31/325 ,  A61K31/4172 ,  A61K31/455

摘要： Methods of treating disorders associated with elevated levels of PAI-1 are disclosed comprising administering to a patient in need thereof a therapeutically effective amount of at least one compound of formula at least one compound of formula (I), or a pharmaceutically-acceptable salt, prodrug, stereoismer or solvate thereof, wherein: A is aryl or heteroaryl, X is O or S, and R1-R9 and R18 are defined herein. The invention also pertains to pharmaceutical compositions and compounds within the scope of formula (I) as well as medicaments and articles of manufacture comprising compounds of formula (I).

摘要翻译： 公开了治疗与升高的PAI-1水平相关的疾病的方法，包括向有需要的患者施用治疗有效量的至少一种式至少一种式（I）化合物或其药学上可接受的盐， 前体药物，立体异构体或溶剂化物，其中：A是芳基或杂芳基，X是O或S，R 1 -R 9和R 18 >在本文中定义。 本发明还涉及式（I）范围内的药物组合物和化合物以及包含式（I）化合物的药物和制品。

公开(公告)号：US20050124664A1

公开(公告)日：2005-06-09

申请号：US10969703

申请日：2004-10-20

申请人： Eric Sartori ,  Magali Maillet ,  Marie Paugam ,  Eric Nicolai ,  Michael Lawrence

发明人： Eric Sartori ,  Magali Maillet ,  Marie Paugam ,  Eric Nicolai ,  Michael Lawrence

IPC分类号： A61K31/433 ,  A61K31/4439 ,  C07D285/12 ,  C07D285/135 ,  C07D405/12 ,  C07D417/12 ,  C07D471/04 ,  C07D417/02

CPC分类号： C07D285/135 ,  A61K31/433 ,  A61K31/4439 ,  C07D405/12 ,  C07D417/12 ,  C07D471/04

摘要： Methods of treating disorders associated with elevated levels of PAI-1 are disclosed comprising administering to a patient in need thereof a therapeutically effective amount of at least one compound of formula (I), or a pharmaceutically-acceptable salt, prodrug, stereoisomer or solvate thereof, wherein: A is aryl o heteroaryl, and R1-R12, are defined herein. The invention also pertains to pharmaceutical compositions and compounds within the scope of formula (I) as well as medicaments and articles of manufacture comprising compounds of formula (I).

摘要翻译： 公开了治疗与升高的PAI-1水平相关的疾病的方法，包括向有需要的患者施用治疗有效量的至少一种式（I）化合物或其药学上可接受的盐，前药，立体异构体或溶剂化物 ，其中：A是芳基o杂芳基，R 1 -R 12，在本文中定义。 本发明还涉及式（I）范围内的药物组合物和化合物以及包含式（I）化合物的药物和制品。

公开(公告)号：US20050143384A1

公开(公告)日：2005-06-30

申请号：US10969692

申请日：2004-10-20

申请人： Eric Sartori ,  Magali Maillet ,  Marie Paugam ,  Eric Nicolai ,  Michael Lawrence

发明人： Eric Sartori ,  Magali Maillet ,  Marie Paugam ,  Eric Nicolai ,  Michael Lawrence

IPC分类号： A61K31/433 ,  A61K31/4439 ,  A61K31/501 ,  A61K31/60 ,  C07D285/12 ,  C07D285/135 ,  C07D417/12 ,  C07D417/02 ,  C07D285/14

CPC分类号： C07D285/135 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/501 ,  A61K31/60 ,  C07D417/12 ,  A61K2300/00

摘要： Methods of treating disorders associated with elevated levels of PAI-1 are disclosed comprising administering to a patient in need thereof a therapeutically effective amount of at least one compound of formula at least one compound of formula (I), or a pharmaceutically-acceptable salt, prodrug, stereoisomer or solvate thereof, wherein: A is aryl or heteroaryl and R1—R11, are defined herein. The invention also pertains to pharmaceutical compositions and compounds within the scope of formula (I) as well as medicaments and articles of manufacture comprising compounds of formula (I).

摘要翻译： 公开了治疗与升高的PAI-1水平相关的疾病的方法，包括向有需要的患者施用治疗有效量的至少一种式至少一种式（I）化合物或其药学上可接受的盐， 前药，立体异构体或其溶剂合物，其中：A是芳基或杂芳基，R 1 -R 11是在本文中定义的。 本发明还涉及式（I）范围内的药物组合物和化合物以及包含式（I）化合物的药物和制品。