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公开(公告)号：US20050124667A1
公开(公告)日：2005-06-09
申请号：US10969480
申请日：2004-10-20
申请人： Eric Sartori , Magali Maillet , Marie Paugam , Eric Nicolai , Michael Lawrence , Karnail Atwal
发明人： Eric Sartori , Magali Maillet , Marie Paugam , Eric Nicolai , Michael Lawrence , Karnail Atwal
IPC分类号： A61K31/165 , A61K31/277 , A61K31/325 , A61K31/4172 , A61K31/455
CPC分类号： A61K31/165 , A61K31/277 , A61K31/325 , A61K31/4172 , A61K31/455
摘要： Methods of treating disorders associated with elevated levels of PAI-1 are disclosed comprising administering to a patient in need thereof a therapeutically effective amount of at least one compound of formula at least one compound of formula (I), or a pharmaceutically-acceptable salt, prodrug, stereoismer or solvate thereof, wherein: A is aryl or heteroaryl, X is O or S, and R1-R9 and R18 are defined herein. The invention also pertains to pharmaceutical compositions and compounds within the scope of formula (I) as well as medicaments and articles of manufacture comprising compounds of formula (I).
摘要翻译： 公开了治疗与升高的PAI-1水平相关的疾病的方法，包括向有需要的患者施用治疗有效量的至少一种式至少一种式（I）化合物或其药学上可接受的盐， 前体药物，立体异构体或溶剂化物，其中：A是芳基或杂芳基，X是O或S，R 1 -R 9和R 18 >在本文中定义。 本发明还涉及式（I）范围内的药物组合物和化合物以及包含式（I）化合物的药物和制品。
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2.发明申请公开(公告)号：US20050143384A1
公开(公告)日：2005-06-30
申请号：US10969692
申请日：2004-10-20
申请人： Eric Sartori , Magali Maillet , Marie Paugam , Eric Nicolai , Michael Lawrence
发明人： Eric Sartori , Magali Maillet , Marie Paugam , Eric Nicolai , Michael Lawrence
IPC分类号： A61K31/433 , A61K31/4439 , A61K31/501 , A61K31/60 , C07D285/12 , C07D285/135 , C07D417/12 , C07D417/02 , C07D285/14
CPC分类号： C07D285/135 , A61K31/433 , A61K31/4439 , A61K31/501 , A61K31/60 , C07D417/12 , A61K2300/00
摘要： Methods of treating disorders associated with elevated levels of PAI-1 are disclosed comprising administering to a patient in need thereof a therapeutically effective amount of at least one compound of formula at least one compound of formula (I), or a pharmaceutically-acceptable salt, prodrug, stereoisomer or solvate thereof, wherein: A is aryl or heteroaryl and R1—R11, are defined herein. The invention also pertains to pharmaceutical compositions and compounds within the scope of formula (I) as well as medicaments and articles of manufacture comprising compounds of formula (I).
摘要翻译： 公开了治疗与升高的PAI-1水平相关的疾病的方法，包括向有需要的患者施用治疗有效量的至少一种式至少一种式（I）化合物或其药学上可接受的盐， 前药，立体异构体或其溶剂合物，其中：A是芳基或杂芳基，R 1 -R 11是在本文中定义的。 本发明还涉及式（I）范围内的药物组合物和化合物以及包含式（I）化合物的药物和制品。
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公开(公告)号：US20050124664A1
公开(公告)日：2005-06-09
申请号：US10969703
申请日：2004-10-20
申请人： Eric Sartori , Magali Maillet , Marie Paugam , Eric Nicolai , Michael Lawrence
发明人： Eric Sartori , Magali Maillet , Marie Paugam , Eric Nicolai , Michael Lawrence
IPC分类号： A61K31/433 , A61K31/4439 , C07D285/12 , C07D285/135 , C07D405/12 , C07D417/12 , C07D471/04 , C07D417/02
CPC分类号： C07D285/135 , A61K31/433 , A61K31/4439 , C07D405/12 , C07D417/12 , C07D471/04
摘要： Methods of treating disorders associated with elevated levels of PAI-1 are disclosed comprising administering to a patient in need thereof a therapeutically effective amount of at least one compound of formula (I), or a pharmaceutically-acceptable salt, prodrug, stereoisomer or solvate thereof, wherein: A is aryl o heteroaryl, and R1-R12, are defined herein. The invention also pertains to pharmaceutical compositions and compounds within the scope of formula (I) as well as medicaments and articles of manufacture comprising compounds of formula (I).
摘要翻译： 公开了治疗与升高的PAI-1水平相关的疾病的方法，包括向有需要的患者施用治疗有效量的至少一种式（I）化合物或其药学上可接受的盐，前药，立体异构体或溶剂化物 ，其中：A是芳基o杂芳基，R 1 -R 12，在本文中定义。 本发明还涉及式（I）范围内的药物组合物和化合物以及包含式（I）化合物的药物和制品。
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4.发明授权3,4-diaryloxazolone derivatives, their methods of preparation and their uses in therapeutics 失效3,4-二恶唑酮衍生物，其制备方法及其在治疗中的应用
公开(公告)号：US5866596A
公开(公告)日：1999-02-02
申请号：US822520
申请日：1997-03-24
申请人： Eric Sartori , Jean-Marie Teulon
发明人： Eric Sartori , Jean-Marie Teulon
IPC分类号： C07D263/38 , A61K31/42
CPC分类号： C07D263/38
摘要： The present invention relates to the derivatives of formula: ##STR1## and to their use in therapeutics, especially as drugs with anti-inflammatory and analgesic properties.
摘要翻译： 本发明涉及下式的衍生物：＆lt; IMAGE＆gt;及其在治疗学中的用途，特别是具有抗炎和镇痛特性的药物。
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5.发明授权3,4-diarylthiazolin-2-one or -2-thione derivatives, their methods of preparation and their uses in their methods of preparation and their uses in therapeutics 失效3,4-二芳基噻唑啉-2-酮或-2-硫酮衍生物，其制备方法及其在治疗中的应用
公开(公告)号：US5859036A
公开(公告)日：1999-01-12
申请号：US962256
申请日：1997-10-31
申请人： Eric Sartori , Jean-Marie Teulon
发明人： Eric Sartori , Jean-Marie Teulon
IPC分类号： C07D277/20 , A61K31/426 , A61P9/00 , A61P15/06 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/28 , A61P29/00 , A61P35/00 , C07D277/34 , C07D277/36 , A61K31/425 , C07D277/14 , C07D277/16
CPC分类号： C07D277/34 , C07D277/36
摘要： The present invention relates to derivatives of formula ##STR1## and to their use in therapeutics especially as drugs with anti-inflammatory and analgesic properties.
摘要翻译： 本发明涉及式“IMAGE”的衍生物及其在治疗学中的用途，特别是具有抗炎和镇痛特性的药物。
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6.发明授权Analgesic .alpha.-amino-N-pyridylbenzenepropanamide derivatives and pharmaceutical compositions containing them 失效止痛α-氨基-N-吡啶基苯丙酰胺衍生物和含有它们的药物组合物
公开(公告)号：US5200408A
公开(公告)日：1993-04-06
申请号：US849709
申请日：1992-03-11
IPC分类号： C07D213/75 , C07D405/12 , C07D409/12
CPC分类号： C07D213/75 , C07D405/12 , C07D409/12
摘要： The present invention relates to the derivatives of the formula ##STR1## in the (S) configuration, to their addition salts and to their use in therapy, especially as drugs with analgesic properties.
摘要翻译： 本发明涉及（S）构型中式（I）的衍生物，其加成盐及其在治疗中的用途，特别是具有止痛性质的药物。
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