公开(公告)号：US07238349B1

公开(公告)日：2007-07-03

申请号：US10088632

申请日：2000-09-27

申请人： Erik D'Hondt ,  Norbert Hehme

发明人： Erik D'Hondt ,  Norbert Hehme

IPC分类号： A61K35/76

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5252 ,  A61K2039/54 ,  A61K2039/543 ,  A61K2039/55505 ,  C07K14/005 ,  C12N2760/16122 ,  C12N2760/16151 ,  C12N2760/16222 ,  C12N2760/16234 ,  C12N2760/16251

摘要： The invention provides a monovalent influenza vaccine comprising a low dose of egg-derived influenza virus antigen from an influenza virus strain that is associated with a pandemic outbreak or has the potential to be associated with a pandemic outbreak, in combination with an aluminium adjuvant. The invention also provides vaccine kits comprising a combination of a parenteral and a mucosal influenza vaccine, wherein the combined dose of antigen is no more than the conventional antigen dose. Also provided are methods for preparing the vaccines.

摘要翻译： 本发明提供了一种单价流感疫苗，其包含与大流行性流感相关的流感病毒毒株的低剂量的来自卵的流感病毒抗原或与大肠杆菌爆发相关联的潜在的铝佐剂。 本发明还提供包含肠胃外和粘膜流感疫苗的组合的疫苗试剂盒，其中抗原的组合剂量不超过常规抗原剂量。 还提供了制备疫苗的方法。

公开(公告)号：US20070141078A1

公开(公告)日：2007-06-21

申请号：US11487769

申请日：2006-07-17

申请人： Erik D'Hondt ,  Norbert Hehme ,  Emmanuel Hanon ,  Jean Stephenne

发明人： Erik D'Hondt ,  Norbert Hehme ,  Emmanuel Hanon ,  Jean Stephenne

IPC分类号： A61K39/395 ,  A61K39/12

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5252 ,  A61K2039/54 ,  A61K2039/543 ,  A61K2039/55505 ,  C07K14/005 ,  C12N2760/16122 ,  C12N2760/16151 ,  C12N2760/16222 ,  C12N2760/16234 ,  C12N2760/16251

摘要： The present invention relates to monovalent influenza vaccine formulations and vaccination regimes for immunising against influenza disease, their use in medicine, in particular their use in augmenting immune responses to various antigens, and to methods of preparation. In particular, the invention relates to monovalent influenza immunogenic compositions comprising an influenza antigen or antigenic preparation thereof from an influenza virus strain being associated with a pandemic outbreak or having the potential to be associated with a pandemic outbreak, in combination with an oil-in-water emulsion adjuvant comprising a metabolisable oil, a sterol or a tocopherol such as alpha tocopherol, and an emulsifying agent.

摘要翻译： 本发明涉及用于免疫流感病毒的单价流感疫苗制剂和疫苗接种方案，它们在医学中的用途，特别是它们在增强对各种抗原的免疫应答中的用途以及制备方法。 特别地，本发明涉及包含流感病毒抗原或其抗原制品的单价流感免疫原性组合物，该流感病毒抗原或其抗原制品与流感大流行爆发相关或具有与大流行性流感相关联的流感病毒株， 水乳剂佐剂，其包含可代谢的油，固醇或生育酚如α-生育酚和乳化剂。