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1.发明授权Application of blend zones, depth reduction, and transition zones to ablation shapes 有权混合区域，深度减少和过渡区域应用于消融形状公开(公告)号：US08216213B2
公开(公告)日：2012-07-10
申请号：US10100231
申请日：2002-03-14
申请人： Erik Gross , Rich Hofer , Jonathan Wong
发明人： Erik Gross , Rich Hofer , Jonathan Wong
IPC分类号： A61F9/008
CPC分类号： A61F9/008 , A61F9/00806 , A61F9/00808 , A61F9/00817 , A61F2009/00844 , A61F2009/00846 , A61F2009/00848 , A61F2009/00872 , A61F2009/0088
摘要： Methods, devices, and systems for reprofiling a surface of a cornea of an eye ablate a portion of the cornea to create an ablation zone with an optically correct central optical zone disposed in a central portion of the cornea, and a blend zone disposed peripherally to the central optical zone and at least partially within an optical zone of the eye. The blend zone can have an optical power that gradually diminishes with increasing radius from the central optical zone.
摘要翻译： 用于重新生成眼睛角膜表面的方法，装置和系统消融角膜的一部分以产生具有设置在角膜中心部分的光学校正中心光学区的消融区，以及混合区， 中心光学区域并且至少部分地在眼睛的光学区域内。 混合区域可以具有随中心光学区域的半径增加而逐渐减小的光学功率。
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2.发明申请APPLICATION OF BLEND ZONES, DEPTH REDUCTION, AND TRANSITION ZONES TO ABLATION SHAPES 审中-公开混合区，深度减少和过渡区应用于排列形状公开(公告)号：US20120271287A1
公开(公告)日：2012-10-25
申请号：US13539605
申请日：2012-07-02
申请人： Erik Gross , Rich Hofer , Jonathan Wong
发明人： Erik Gross , Rich Hofer , Jonathan Wong
IPC分类号： A61F9/01
CPC分类号： A61F9/008 , A61F9/00806 , A61F9/00808 , A61F9/00817 , A61F2009/00844 , A61F2009/00846 , A61F2009/00848 , A61F2009/00872 , A61F2009/0088
摘要： Methods, devices, and systems for reprofiling a surface of a cornea of an eye ablate a portion of the cornea to create an ablation zone with an optically correct central optical zone disposed in a central portion of the cornea, and a blend zone disposed peripherally to the central optical zone and at least partially within an optical zone of the eye. The blend zone can have an optical power that gradually diminishes with increasing radius from the central optical zone.
摘要翻译： 用于重新生成眼睛角膜表面的方法，装置和系统消融角膜的一部分以产生具有设置在角膜中心部分的光学校正中心光学区的消融区，以及混合区， 中心光学区域并且至少部分地在眼睛的光学区域内。 混合区域可以具有随中心光学区域的半径增加而逐渐减小的光学功率。
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公开(公告)号：US10449089B2
公开(公告)日：2019-10-22
申请号：US13539605
申请日：2012-07-02
申请人： Erik Gross , Rich Hofer , Jonathan Wong
发明人： Erik Gross , Rich Hofer , Jonathan Wong
IPC分类号： A61F9/008
摘要： Methods, devices, and systems for reprofiling a surface of a cornea of an eye ablate a portion of the cornea to create an ablation zone with an optically correct central optical zone disposed in a central portion of the cornea, and a blend zone disposed peripherally to the central optical zone and at least partially within an optical zone of the eye. The blend zone can have an optical power that gradually diminishes with increasing radius from the central optical zone.
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公开(公告)号：US06964659B2
公开(公告)日：2005-11-15
申请号：US10447667
申请日：2003-05-28
申请人： Erik Gross , Kingman Yee , Jonathan Wong
发明人： Erik Gross , Kingman Yee , Jonathan Wong
CPC分类号： A61F9/008 , A61B34/10 , A61F9/00806 , A61F9/00817 , A61F2009/00846 , A61F2009/00848 , A61F2009/00872 , A61F2009/0088
摘要： The present invention provides systems and methods for applying pulsed energy to an eye. In an exemplary embodiment, a firing rate of the pulsed energy varies in correlation with a modeled or estimated thermal response of a tissue of the eye to the pulses of the laser beam during the treatment.
摘要翻译： 本发明提供了向眼睛施加脉冲能量的系统和方法。 在示例性实施例中，脉冲能量的燃烧速率与处理期间的眼睛组织对激光束的脉冲的建模或估计的热响应相关。
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公开(公告)号：US09388427B2
公开(公告)日：2016-07-12
申请号：US12320434
申请日：2009-01-26
申请人： Lakshman R. Sehgal , Jonathan Wong
发明人： Lakshman R. Sehgal , Jonathan Wong
IPC分类号： C12N15/11 , A61K39/235 , C12N15/861 , A61K31/715 , A01N63/00 , C07H21/04 , C12N15/86 , A61K38/44 , A61K39/00 , C07K14/745 , C12N7/00 , A61K48/00 , A61K38/00
CPC分类号： C12N15/86 , A61K38/00 , A61K38/44 , A61K39/001 , A61K48/00 , A61K48/005 , A61K48/0058 , A61K48/0075 , C07K14/7455 , C12N7/00 , C12N2710/10343 , C12N2830/008 , C12Y113/11052
摘要： A method for treating a renal disease in a subject is disclosed. The method includes administering into a kidney of the subject with an effective amount of a gutless adenoviral vector containing a polynucleotide encoding a therapeutic agent. The gutless adenoviral vector contains the nucleotide sequence of SEQ ID NO:13 or SEQ ID NO:15 and expresses the therapeutic agent in a kidney tissue of the subject.
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公开(公告)号：US08420075B2
公开(公告)日：2013-04-16
申请号：US12750219
申请日：2010-03-30
申请人： Lakshman R. Sehgal , Jonathan Wong
发明人： Lakshman R. Sehgal , Jonathan Wong
IPC分类号： A01N63/00 , A61K31/715 , A61K39/235 , C07H21/04 , C12N15/861
CPC分类号： C07K14/7455 , A61K38/00 , A61K48/00 , A61K48/005 , C12N15/86 , C12N2710/10343 , C12N2799/022 , C12N2830/008
摘要： The present invention relates to methods and compositions for treatment of cardiovascular and peripheral vascular diseases using ex vivo and in vivo gene delivery technologies. One aspect of the present invention relates to a method for treating a vascular disease by introducing a DNA sequence encoding a TM protein or its variant into a segment of a blood vessel in vivo using a gutless adenovirus vector. Another aspect of the present invention is to provide a method to deliver a gutless adenovirus vector carrying a DNA sequence encoding a TM protein or its variant using a stent.
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7.发明授权Operator-controlled scanning laser procedure designed for large-area epithelium removal 有权操作员控制的扫描激光程序设计用于大面积去皮公开(公告)号：US08292878B2
公开(公告)日：2012-10-23
申请号：US13073747
申请日：2011-03-28
IPC分类号： A61B18/18
CPC分类号： A61F9/008 , A61B2017/00057 , A61F9/00806 , A61F9/00817 , A61F2009/00844 , A61F2009/00848 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882 , A61F2009/00897
摘要： Systems and methods for removing an epithelial layer disposed over a stromal layer in a cornea irradiate a region of the epithelial layer with a pulsed beam of ablative radiation. The ablative radiation is scanned to vary the location of the beam within the region in accordance with a pulse sequence. The pulse sequence is arranged to enhance optical feedback based on a tissue fluorescence of the epithelial layer. The penetration of the epithelial layer is detected in response to the optical feedback. The use of scanning with the pulse sequence arranged to enhance optical feedback allows large areas of the epithelium to be ablated such that an operator can detect penetration of the epithelial layer.
摘要翻译： 用于去除设置在角膜上的基质层上的上皮层的系统和方法用消融辐射的脉冲束照射上皮层的区域。 根据脉冲序列扫描烧蚀辐射以改变该区域内的光束的位置。 布置脉冲序列以增强基于上皮层的组织荧光的光学反馈。 响应于光学反馈检测上皮层的穿透。 使用布置成增强光学反馈的脉冲序列的扫描允许上皮的大面积被消融，使得操作者可以检测上皮层的穿透。
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公开(公告)号：US20110307076A1
公开(公告)日：2011-12-15
申请号：US13180378
申请日：2011-07-11
申请人： Lakshman R. SEHGAL , Jonathan Wong
发明人： Lakshman R. SEHGAL , Jonathan Wong
CPC分类号： C12N15/86 , A61K38/00 , A61K38/44 , A61K39/001 , A61K48/00 , A61K48/005 , A61K48/0058 , A61K48/0075 , C07K14/7455 , C12N7/00 , C12N2710/10343 , C12N2830/008 , C12Y113/11052
摘要： A method for treating a renal disease in a subject is disclosed. The method includes administering into a kidney of the subject with an effective amount of a gutless adenoviral vector containing a polynucleotide encoding a therapeutic agent. The gutless adenoviral vector contains the nucleotide sequence of SEQ ID NO:13 or SEQ ID NO:15 and expresses the therapeutic agent in a kidney tissue of the subject.
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9.发明授权Operator-controlled scanning laser procedure designed for large-area epithelium removal 有权操作员控制的扫描激光程序设计用于大面积去皮公开(公告)号：US07931644B2
公开(公告)日：2011-04-26
申请号：US11937760
申请日：2007-11-09
IPC分类号： A61B18/20
CPC分类号： A61F9/008 , A61B2017/00057 , A61F9/00806 , A61F9/00817 , A61F2009/00844 , A61F2009/00848 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882 , A61F2009/00897
摘要： Systems and methods for removing an epithelial layer disposed over a stromal layer in a cornea irradiate a region of the epithelial layer with a pulsed beam of ablative radiation. The ablative radiation is scanned to vary the location of the beam within the region in accordance with a pulse sequence. The pulse sequence is arranged to enhance optical feedback based on a tissue fluorescence of the epithelial layer. The penetration of the epithelial layer is detected in response to the optical feedback. The use of scanning with the pulse sequence arranged to enhance optical feedback allows large areas of the epithelium to be ablated such that an operator can detect penetration of the epithelial layer.
摘要翻译： 用于去除设置在角膜上的基质层上的上皮层的系统和方法用消融辐射的脉冲束照射上皮层的区域。 根据脉冲序列扫描烧蚀辐射以改变该区域内的光束的位置。 布置脉冲序列以增强基于上皮层的组织荧光的光学反馈。 响应于光学反馈检测上皮层的穿透。 使用布置成增强光学反馈的脉冲序列的扫描允许上皮的大面积被消融，使得操作者可以检测上皮层的穿透。
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公开(公告)号：US20050102008A1
公开(公告)日：2005-05-12
申请号：US10447665
申请日：2003-05-28
申请人： Jonathan Wong
发明人： Jonathan Wong
CPC分类号： A61F9/008 , A61B34/10 , A61F9/00806 , A61F9/00817 , A61F2009/00844 , A61F2009/00846 , A61F2009/00848 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882
摘要： Systems and methods apply pulsed laser energy to an eye with a pulsed laser system. The laser system includes a pulsed laser, a laser beam delivery system and at least one processor. The laser makes a beam of an ablative light energy. A dimension across the laser beam varies during a treatment of the eye. A firing rate of the laser varies as the dimension across the beam varies during the treatment. The dimension across the beam and the firing rate of the laser can be arranged so as to maintain a power of the beam applied to the eye at a substantially constant level during at least a portion of the treatment. A firing rate of the laser for each pulse may be listed in a treatment table.
摘要翻译： 系统和方法使用脉冲激光系统将脉冲激光能量应用于眼睛。 激光系统包括脉冲激光器，激光束传送系统和至少一个处理器。 激光产生烧蚀光束。 在治疗眼睛期间，穿过激光束的尺寸变化。 激光的燃烧速率随着治疗期间横梁的尺寸变化而变化。 横梁上的尺寸和激光的射出速率可被布置成在治疗的至少一部分期间将施加到眼睛的光束的功率保持在基本恒定的水平。 每个脉冲的激光的点火速率可以列在治疗台中。
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