公开(公告)号：US07670764B2

公开(公告)日：2010-03-02

申请号：US10971195

申请日：2004-10-22

申请人： Esther H. Oh ,  Catherine M. Smith

发明人： Esther H. Oh ,  Catherine M. Smith

IPC分类号： C12Q1/04 ,  C12Q1/70 ,  A61K39/29

CPC分类号： C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2800/52

摘要： The present invention provides a method of diagnosing the presence or severity of tissue fibrosis in an individual by detecting α2-macroglobulin (α2-MG) in a sample from the individual; detecting hyaluronic acid (HA) in a sample from the individual; detecting tissue inhibitor of metalloproteinases-1 (TIMP-1) in a sample from the individual; and diagnosing the presence or severity of tissue fibrosis in the individual based on the presence or level of α2-MG, HA and TIMP-1.

摘要翻译： 本发明提供一种通过检测来自个体的样品中的α2-巨球蛋白（α2-MG）来诊断个体中组织纤维化的存在或严重程度的方法; 检测来自个体的样品中的透明质酸（HA）; 检测来自个体的样品中金属蛋白酶-1（TIMP-1）的组织抑制剂; 并根据α2-MG，HA和TIMP-1的存在或水平诊断个体组织纤维化的存在或严重程度。

公开(公告)号：US20100317022A1

公开(公告)日：2010-12-16

申请号：US12695126

申请日：2010-01-27

申请人： Esther H. Oh ,  Catherine M. Smith

发明人： Esther H. Oh ,  Catherine M. Smith

IPC分类号： G01N33/53

CPC分类号： C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2800/52

摘要： The present invention provides a method of diagnosing the presence or severity of tissue fibrosis in an individual by detecting α2-macroglobulin (α2-MG) in a sample from the individual; detecting hyaluronic acid (HA) in a sample from the individual; detecting tissue inhibitor of metalloproteinases-1 (TIMP-1) in a sample from the individual; and diagnosing the presence or severity of tissue fibrosis in the individual based on the presence or level of α2-MG, HA and TIMP-1.

摘要翻译： 本发明提供一种通过检测来自个体的样品中的α2-巨球蛋白（α2-MG）来诊断个体中组织纤维化的存在或严重程度的方法; 检测来自个体的样品中的透明质酸（HA）; 检测来自个体的样品中金属蛋白酶-1（TIMP-1）的组织抑制剂; 并根据α2-MG，HA和TIMP-1的存在或水平诊断个体组织纤维化的存在或严重程度。

公开(公告)号：US06986995B2

公开(公告)日：2006-01-17

申请号：US10087188

申请日：2002-02-28

申请人： Steven L. Rose ,  Esther H. Oh ,  Michael J. Walsh

发明人： Steven L. Rose ,  Esther H. Oh ,  Michael J. Walsh

IPC分类号： C12Q1/37 ,  G01N33/576 ,  G01N33/68

CPC分类号： G01N33/5767 ,  G01N33/6893 ,  G01N2333/4713 ,  G01N2333/8107 ,  G01N2333/8146 ,  G01N2800/085 ,  G01N2800/52 ,  G06F19/00 ,  Y02A90/24 ,  Y02A90/26 ,  Y10S436/811 ,  Y10S436/82 ,  Y10S706/924 ,  Y10T436/143333

摘要： The present invention provides a method of diagnosing the presence or severity of liver fibrosis in an individual by detecting α2-macroglobulin (α2-MG) in a sample from the individual; detecting hyaluronic acid (HA) in a sample from the individual; detecting tissue inhibitor of metalloproteinases-1 (TIMP-1) in a sample from the individual; and diagnosing the presence or severity of liver fibrosis in the individual based on the presence or level of α2-MG, HA and TIMP-1.

公开(公告)号：US07759079B2

公开(公告)日：2010-07-20

申请号：US11128011

申请日：2005-05-11

申请人： Esther H. Oh ,  John F. Marcelletti ,  Susan M. Carroll ,  Katie M. Smith

发明人： Esther H. Oh ,  John F. Marcelletti ,  Susan M. Carroll ,  Katie M. Smith

IPC分类号： G01N33/53

CPC分类号： G01N33/6893 ,  G01N2800/065 ,  G01N2800/52

摘要： The present invention provides methods for diagnosing the presence or severity of inflammatory bowel disease (IBD) in an individual and methods for stratifying IBD by determining the level of one or more IBD markers in a sample from the individual and calculating an index value using an algorithm based upon the level of the IBD markers. Methods for monitoring the efficacy of IBD therapy, monitoring the progression or regression of IBD, and optimizing therapy in an individual having IBD are also provided.

摘要翻译： 本发明提供用于诊断个体中炎症性肠病（IBD）的存在或严重性的方法以及通过确定来自个体的样品中的一种或多种IBD标记物的水平来分级IBD的方法，并使用算法计算指数值 基于IBD标记的水平。 还提供了用于监测IBD治疗的功效，监测IBD的进展或消退以及优化IBD个体治疗的方法。