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    ANTI-CLUSTERIN MONOTHERAPY FOR CANCER TREATMENT
    5.
    发明申请
    ANTI-CLUSTERIN MONOTHERAPY FOR CANCER TREATMENT 审中-公开
    用于癌症治疗的抗CLUSTERIN单克隆抗体

    公开(公告)号：US20140275215A1

    公开(公告)日：2014-09-18

    申请号：US14207471

    申请日：2014-03-12

    申请人： Shoshi Tessler ,  Joel Kaye ,  Tania Fine ,  Rina Kashi

    发明人： Shoshi Tessler ,  Joel Kaye ,  Tania Fine ,  Rina Kashi

    IPC分类号： C12N15/113

    CPC分类号： C12N15/113 ,  A61K31/711 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2320/35 ,  C12N2310/321 ,  C12N2310/3525

    摘要： The present invention provides a method of treating cancer in a subject afflicted with cancer comprising administering to the subject an anti-clusterin oligonucleotide as a monotherapy to treat the cancer. The present invention also provides compositions for treating cancer in a subject afflicted with cancer, comprising an anti-clusterin oligonucleotide having the sequence CAGCAGCAGAGTCTTCATCAT (Seq. ID No.: 1). Additionally, the present invention provides pharmaceutical compositions for treating cancer in a subject afflicted with cancer, the composition comprising an anti-clusterin oligonucleotide having the sequence CAGCAGCAGAGTCTTCATCAT (Seq. ID No.: 1), wherein the anti-clusterin oligonucleotide has a phosphorothioate backbone throughout, has sugar moieties of nucleotides 1-4 and 18-21 bearing 2′-O-methoxyethyl modifications, has nucleotides 5-17 which are 2′deoxynucleotides, and has 5-methylcytosines at nucleotides 1, 4, and 19.

    摘要翻译： 本发明提供了治疗患有癌症的受试者中的癌症的方法，其包括向受试者施用抗簇蛋白寡核苷酸作为单一疗法以治疗癌症。 本发明还提供用于治疗患有癌症的受试者的癌症的组合物，其包含具有CAGCAGCAGAGTCTTCATCAT（Seq.ID No .: 1）序列的抗聚集蛋白寡核苷酸。 另外，本发明提供用于治疗患有癌症的受试者的癌症的药物组合物，该组合物包含具有CAGCAGCAGAGTCTTCATCAT（Seq.ID No .: 1）序列的抗聚集蛋白寡核苷酸，其中抗聚集蛋白寡核苷酸具有硫代磷酸酯骨架 全部具有含有2'-O-甲氧基乙基修饰的核苷酸1-4和18-21的糖部分具有2'-脱氧核苷酸的核苷酸5-17，在核苷酸1,4和19具有5-甲基胞嘧啶。

    METHOD FOR TREATING NON-SMALL CELL LUNG CANCER
    6.
    发明申请
    METHOD FOR TREATING NON-SMALL CELL LUNG CANCER 审中-公开
    用于治疗非小细胞肺癌的方法

    公开(公告)号：US20130310440A1

    公开(公告)日：2013-11-21

    申请号：US13896737

    申请日：2013-05-17

    申请人： Chen Duksin ,  Shoshi Tessler

    发明人： Chen Duksin ,  Shoshi Tessler

    IPC分类号： A61K31/713 ,  A61K31/337

    CPC分类号： A61K31/713 ,  A61K31/337 ,  G01N33/57423 ,  A61K2300/00

    摘要： The present invention provides methods for treating a human patient afflicted with unresectable, advanced or metastatic non-small cell lung cancer comprising periodically administering to the human patient chemotherapy comprising an amount of docetaxel; and 640 mg of an anti-clusterin oligonucleotide having the sequence CAGCAGCAGAGTCTTCATCAT (Seq. ID No.: 1), wherein the anti-clusterin oligonucleotide has a phosphorothioate backbone throughout, has sugar moieties of nucleotides 1-4 and 18-21 bearing 2′-O-methoxyethyl modifications, has nucleotides 5-17 which are 2′deoxynucleotides, and has 5-methylcytosines at nucleotides 1, 4, and 19, thereby treating the human patient afflicted with unresectable, advanced or metastatic non-small cell lung cancer. The present invention also provides compositions and combinations, packages, and uses thereof for treating a human patient afflicted with unresectable, advanced or metastatic non-small cell lung cancer.

    摘要翻译： 本发明提供了治疗患有不可切除，晚期或转移性非小细胞肺癌的人类患者的方法，其包括定期施用包含一定量的多西紫杉醇的人类患者化学疗法; 和640mg具有序列CAGCAGCAGAGTCTTCATCAT（Seq.ID No .: 1）的抗聚簇蛋白寡核苷酸，其中抗聚簇蛋白寡核苷酸全部具有硫代磷酸酯主链，具有含有2'端的核苷酸1-4和18-21的糖部分， -O-甲氧基乙基修饰，具有2个脱氧核苷酸的核苷酸5-17，并且在核苷酸1,4和19处具有5-甲基胞嘧啶，从而治疗患有不可切除，晚期或转移性非小细胞肺癌的人类患者。 本发明还提供用于治疗患有不可切除，晚期或转移性非小细胞肺癌的人类患者的组合物和组合，包装及其用途。

    METHOD FOR TREATING NON-SMALL CELL LUNG CANCER
    7.
    发明申请
    METHOD FOR TREATING NON-SMALL CELL LUNG CANCER 审中-公开
    用于治疗非小细胞肺癌的方法

    公开(公告)号：US20130017272A1

    公开(公告)日：2013-01-17

    申请号：US13475780

    申请日：2012-05-18

    申请人： Chen DUKSIN ,  Shoshi Tessler

    发明人： Chen DUKSIN ,  Shoshi Tessler

    IPC分类号： A61K31/711 ,  A61P35/04 ,  A61K33/24 ,  A61P35/00

    CPC分类号： C12N15/113 ,  C12N2310/11 ,  C12N2320/31

    摘要： A method of treating a human patient afflicted with lung cancer comprising periodically administering to the human patient chemotherapy comprising an amount of a taxane and 640 mg of an anti-clusterin oligonucleotide having the sequence CAGCAGCAGAGTCTTCATCAT (Seq. ID No.: 1), wherein the anti-clusterin oligonucleotide has a phosphorothioate backbone throughout, has sugar moieties of nucleotides 1-4 and 18-21 bearing 2′-O-methoxyethyl modifications, has nucleotides 5-17 which are 2′ deoxynucleotides, and has 5-methylcytosines at nucleotides 1, 4, and 19, thereby treating the human patient afflicted with cell lung cancer.

    摘要翻译： 一种治疗患有肺癌的人类患者的方法，其包括定期施用包含一定量的紫杉烷的人类患者化疗和640mg具有序列CAGCAGCAGAGTCTTCATCAT（Seq.ID No .: 1）的抗聚簇蛋白寡核苷酸，其中 抗聚簇蛋白寡核苷酸全部具有硫代磷酸酯骨架，具有含有2'-O-甲氧基乙基修饰的核苷酸1-4和18-21的糖部分，具有2'脱氧核苷酸的核苷酸5-17，并且在核苷酸1具有5-甲基胞嘧啶 4和19，从而治疗患有细胞肺癌的人类患者。