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1.发明授权公开(公告)号：US08415314B2
公开(公告)日：2013-04-09
申请号：US12456883
申请日：2009-06-23
CPC分类号： C07H21/00 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： A method for treating a patient suffering from multiple sclerosis, particularly a relapsing form of multiple sclerosis, comprising periodically administering a pharmaceutical composition comprising a therapeutically effective amount of OLIGONUCLEOTIDE 1 to the patient, thereby treating the patient.
摘要翻译： 一种用于治疗患有多发性硬化，特别是复发型多发性硬化症的患者的方法，包括向患者周期性地施用包含治疗有效量的寡核苷酸1的药物组合物，从而治疗患者。
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2.发明申请公开(公告)号：US20130345293A1
公开(公告)日：2013-12-26
申请号：US13848811
申请日：2013-03-22
IPC分类号： C07H21/00
CPC分类号： C07H21/00 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： A method for treating a patient suffering from multiple sclerosis, particularly a relapsing form of multiple sclerosis, comprising periodically administering a pharmaceutical composition comprising a therapeutically effective amount of OLIGONUCLEOTIDE 1 to the patient, thereby treating the patient.
摘要翻译： 一种用于治疗患有多发性硬化，特别是复发型多发性硬化症的患者的方法，包括向患者周期性地施用包含治疗有效量的寡核苷酸1的药物组合物，从而治疗患者。
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3.发明申请公开(公告)号：US20100119480A1
公开(公告)日：2010-05-13
申请号：US12456883
申请日：2009-06-23
IPC分类号： A61K38/21 , A61K31/7088 , A61K39/395 , A61P37/06
CPC分类号： C07H21/00 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： A method for treating a patient suffering from multiple sclerosis, particularly a relapsing form of multiple sclerosis, comprising periodically administering a pharmaceutical composition comprising a therapeutically effective amount of OLIGONUCLEOTIDE 1 to the patient, thereby treating the patient.
摘要翻译： 一种用于治疗患有多发性硬化，特别是复发型多发性硬化症的患者的方法，包括向患者周期性地施用包含治疗有效量的寡核苷酸1的药物组合物，从而治疗患者。
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4.发明授权公开(公告)号：US08759314B2
公开(公告)日：2014-06-24
申请号：US13848811
申请日：2013-03-22
CPC分类号： C07H21/00 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： A method for treating a patient suffering from multiple sclerosis, particularly a relapsing form of multiple sclerosis, comprising periodically administering a pharmaceutical composition comprising a therapeutically effective amount of OLIGONUCLEOTIDE 1 to the patient, thereby treating the patient.
摘要翻译： 一种用于治疗患有多发性硬化，特别是复发型多发性硬化症的患者的方法，包括向患者周期性地施用包含治疗有效量的寡核苷酸1的药物组合物，从而治疗患者。
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5.发明授权Modulation of growth hormone receptor expression and insulin-like growth factor expression 有权调节生长激素受体表达和胰岛素样生长因子表达公开(公告)号：US08299039B2
公开(公告)日：2012-10-30
申请号：US10927466
申请日：2004-08-25
CPC分类号： C12N15/1138 , C07K14/72 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y10T436/143333 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of growth hormone receptor and/or insulin like growth factor-I (IGF-I). The compositions comprise oligonucleotides, targeted to nucleic acid encoding growth hormone receptor. Methods of using these compounds for modulation of growth hormone receptor expression and for diagnosis and treatment of disease associated with expression of growth hormone receptor and/or insulin-like growth factor-I are provided. Diagnostic methods and kits are also provided.
摘要翻译： 提供化合物，组合物和方法用于调节生长激素受体和/或胰岛素样生长因子-I（IGF-I）的表达。 组合物包含针对编码生长激素受体的核酸的寡核苷酸。 提供了使用这些化合物调节生长激素受体表达和用于诊断和治疗与生长激素受体和/或胰岛素样生长因子-I表达相关的疾病的方法。 还提供诊断方法和试剂盒。
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6.发明授权公开(公告)号：US08623836B2
公开(公告)日：2014-01-07
申请号：US12953105
申请日：2010-11-23
申请人： George Tachas , Kenneth Dobie , Ravi Jain , Christopher Belyea , Mark Heffernan
发明人： George Tachas , Kenneth Dobie , Ravi Jain , Christopher Belyea , Mark Heffernan
CPC分类号： C12N15/1138 , A61K47/554 , C12N2310/11 , C12N2320/30 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/74 , G01N2333/71 , Y10T436/143333
摘要： Compounds, compositions and methods are provided for modulating the expression of growth hormone receptor and/or insulin like growth factor-I (IGF-I). The compositions comprise oligonucleotides, targeted to nucleic acid encoding growth hormone receptor. Methods of using these compounds for modulation of growth hormone receptor expression and for diagnosis and treatment of disease associated with expression of growth hormone receptor and/or insulin-like growth factor-I are provided. Diagnostic methods and kits are also provided.
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7.发明申请Modulation of growth hormone receptor expression and insulin-like growth factor expression 有权调节生长激素受体表达和胰岛素样生长因子表达公开(公告)号：US20050282761A1
公开(公告)日：2005-12-22
申请号：US10927466
申请日：2004-08-25
申请人： George Tachas , Kenneth Dobie , Ravi Jain , Christopher Belyea , Mark Heffernan
发明人： George Tachas , Kenneth Dobie , Ravi Jain , Christopher Belyea , Mark Heffernan
IPC分类号： A61K31/7088 , A61K48/00 , C07H21/00 , C07H21/02 , C07H21/04 , C07K14/72 , C12N20060101 , C12N9/10 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/1138 , C07K14/72 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y10T436/143333 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of growth hormone receptor and/or insulin like growth factor-I (IGF-I). The compositions comprise oligonucleotides, targeted to nucleic acid encoding growth hormone receptor. Methods of using these compounds for modulation of growth hormone receptor expression and for diagnosis and treatment of disease associated with expression of growth hormone receptor and/or insulin-like growth factor-I are provided. Diagnostic methods and kits are also provided.
摘要翻译： 提供化合物，组合物和方法用于调节生长激素受体和/或胰岛素样生长因子-I（IGF-I）的表达。 组合物包含针对编码生长激素受体的核酸的寡核苷酸。 提供了使用这些化合物调节生长激素受体表达和用于诊断和治疗与生长激素受体和/或胰岛素样生长因子-I表达相关的疾病的方法。 还提供诊断方法和试剂盒。
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8.发明申请Modulation of growth hormone receptor expression and insulin-like growth factor expression 有权调节生长激素受体表达和胰岛素样生长因子表达公开(公告)号：US20060178325A1
公开(公告)日：2006-08-10
申请号：US10547239
申请日：2004-02-27
申请人： George Tachas , Kenneth Dobie , Christopher Belyea , Mark Heffernan , Ravi Jain
发明人： George Tachas , Kenneth Dobie , Christopher Belyea , Mark Heffernan , Ravi Jain
CPC分类号： C12N15/1138 , A61K47/554 , C12N2310/11 , C12N2320/30 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/74 , G01N2333/71 , Y10T436/143333
摘要： Compounds, compositions and methods are provided for modulating the expression of growth hormone receptor and/or insulin like growth factor-I (IGF-I). The compositions comprise oligonucleotides, targeted to nucleic acid encoding growth hormone receptor. Methods of using these compounds for modulation of growth hormone receptor expression and for diagnosis and treatment of disease associated with expression of growth hormone receptor and/or insulin-like growth factor-I are provided. Diagnostic methods and kits are also provided.
摘要翻译： 提供化合物，组合物和方法用于调节生长激素受体和/或胰岛素样生长因子-I（IGF-I）的表达。 组合物包含针对编码生长激素受体的核酸的寡核苷酸。 提供了使用这些化合物调节生长激素受体表达和用于诊断和治疗与生长激素受体和/或胰岛素样生长因子-I表达相关的疾病的方法。 还提供诊断方法和试剂盒。
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9.发明授权公开(公告)号：US09084770B2
公开(公告)日：2015-07-21
申请号：US12578471
申请日：2009-10-13
IPC分类号： C12N15/113 , A61K31/337 , A61K31/7052
CPC分类号： C12N15/1138 , A61K31/337 , A61K31/7052 , A61K31/7088 , A61K45/06 , C12N2310/11 , C12N2320/30 , A61K2300/00
摘要： Provided herein are methods, compounds, and compositions for reducing expression of an IGF-IR mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions that inhibit expression of IGF-IR in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate the tumor or cancer, or a symptom thereof.
摘要翻译： 本文提供了用于减少动物体内IGF-1R mRNA和蛋白质表达的方法，化合物和组合物。 本文还提供抑制动物中IGF-1R表达的方法，化合物和组合物。 这些方法，化合物和组合物可用于治疗，预防，延迟或改善肿瘤或癌症或其症状。
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10.发明授权Topical administrations of antisense compounds to VLA-4 for the treatment of respiratory conditions 失效用于治疗呼吸道疾病的VLA-4反义化合物的局部给药公开(公告)号：US08765700B2
公开(公告)日：2014-07-01
申请号：US11666001
申请日：2005-10-20
申请人： George Tachas , James G. Karras , Susan Gregory , Jeffrey R. Crosby , Kenneth W. Dobie , Frank C. Bennett
发明人： George Tachas , James G. Karras , Susan Gregory , Jeffrey R. Crosby , Kenneth W. Dobie , Frank C. Bennett
IPC分类号： C12N15/11
CPC分类号： A61K31/711 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： A method for the treatment and/or prophylaxis of an animal having a respiratory disease or condition associated with airway hyperresponsiveness, eosinophilia, neutrophilia, leukocytes or overproduction of mucus and/or with the expression of integrin α4 comprising administering to the animal a composition comprising from. 0.001 to 1000 μg per kg body weight of the animal of an antisense compound targeted to a nucleic acid molecule encoding integrin α4.
摘要翻译： 用于治疗和/或预防具有呼吸道疾病或与气道高反应性，嗜酸性粒细胞增多症，嗜中性粒细胞减少，白细胞或过度产生粘液和/或整合素α4相关的病症的动物的方法，包括向动物施用包含 。 0.001至1000μg/ kg体重的靶向编码整联蛋白α4的核酸分子的反义化合物的动物。
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