公开(公告)号：US06887694B1

公开(公告)日：2005-05-03

申请号：US09710262

申请日：2000-11-10

申请人： Eugene Rosenberg ,  Eliora Ron ,  Elisha Orr ,  Yossi Paitan

发明人： Eugene Rosenberg ,  Eliora Ron ,  Elisha Orr ,  Yossi Paitan

IPC分类号： C12N15/52 ,  C12N9/00

CPC分类号： C12N15/52

摘要： There is provided DNA sequences isolated from Myxococcus xanthus partially encoding a functional portion of a polypeptide component required for the synthesis of antibiotic TA. Also provided are purified, isolated and cloned DNA sequences encoding a polypeptide component required for postmodification of antibiotic TA and encoding a gene product involved in the regulation of the biosynthesis of antibiotic TA. A purified, isolated and cloned DNA sequence having a DNA sequence (seq. ID No:2 and 20) encoding a polypeptide component required for encoding the TA gene cluster and any mutations thereof is provided. Also provided are methods of using the TA genes for combinatorial genetics and of using the TA genes encoding for synthesis and modification or regulation of antibiotic TA.

摘要翻译： 提供了从部分编码合成抗生素TA所需的多肽组分的功能部分的黄链球菌分离的DNA序列。 还提供了纯化，分离和克隆的DNA序列，其编码抗生素TA后修饰所需的多肽组分，并编码参与抗生素TA生物合成调控的基因产物。 提供了具有编码TA基因簇编码所需的多肽组分及其任何突变的DNA序列（序列号：2和20）的纯化，分离和克隆的DNA序列。 还提供了使用TA基因进行组合遗传学和使用编码抗生素TA的合成和修饰或调节的TA基因的方法。

公开(公告)号：US20080108109A1

公开(公告)日：2008-05-08

申请号：US11905592

申请日：2007-10-02

申请人： Eugene Rosenberg ,  Eliora Ron ,  Elisha Orr ,  Yossi Paitan

发明人： Eugene Rosenberg ,  Eliora Ron ,  Elisha Orr ,  Yossi Paitan

IPC分类号： C12P19/00

CPC分类号： C12N9/52 ,  C12N15/52 ,  C12P17/14

摘要： A method of producing an antibiotic TA comprising (i) expressing in a host cell an exogenous polynucleotide sequence encoding at least one polypeptide selected from the group consisting of SEQ ID NOs: 1 and 3-19; and (ii) culturing the host cell under conditions suitable for synthesis of the antibiotic TA, thereby producing the antibiotic TA.

摘要翻译： 一种生产抗生素TA的方法，包括（i）在宿主细胞中表达编码选自SEQ ID NO：1和3-19的至少一种多肽的外源多核苷酸序列; 和（ii）在适于合成抗生素TA的条件下培养宿主细胞，从而产生抗生素TA。

公开(公告)号：US20080057038A1

公开(公告)日：2008-03-06

申请号：US11850942

申请日：2007-09-06

申请人： Iftach Yacoby ,  Eliora Ron ,  Doron Shabat ,  Marina Shamis ,  Itai Benhar

发明人： Iftach Yacoby ,  Eliora Ron ,  Doron Shabat ,  Marina Shamis ,  Itai Benhar

IPC分类号： A61K38/00 ,  A61P31/00 ,  C12N7/00

CPC分类号： A61K47/62

摘要： The present invention relates to the field of drug delivery. More specifically, the invention relates to the preparation and use of a bacteriophage conjugated through a labile/non labile linker or directly to at least 1,000 therapeutic drug molecules such that the drug molecules are conjugated to the outer surface of the bacteriophage. The bacteriophage optionally displays on its coat a ligand that endows it with specificity towards target cells. Thus, there is provided a targeted, high-capacity drug delivery system useful for the treatment of various pathological conditions.

摘要翻译： 本发明涉及药物递送领域。 更具体地，本发明涉及通过不稳定/非不稳定接头缀合的或直接与至少1,000种治疗性药物分子结合的噬菌体的制备和用途，使得药物分子与噬菌体的外表面缀合。 噬菌体任选地在其外壳上显示赋予其对靶细胞特异性的配体。 因此，提供了可用于治疗各种病理状况的靶向高容量药物递送系统。