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公开(公告)号：US20080057038A1
公开(公告)日：2008-03-06
申请号：US11850942
申请日：2007-09-06
申请人： Iftach Yacoby , Eliora Ron , Doron Shabat , Marina Shamis , Itai Benhar
发明人： Iftach Yacoby , Eliora Ron , Doron Shabat , Marina Shamis , Itai Benhar
CPC分类号： A61K47/62
摘要： The present invention relates to the field of drug delivery. More specifically, the invention relates to the preparation and use of a bacteriophage conjugated through a labile/non labile linker or directly to at least 1,000 therapeutic drug molecules such that the drug molecules are conjugated to the outer surface of the bacteriophage. The bacteriophage optionally displays on its coat a ligand that endows it with specificity towards target cells. Thus, there is provided a targeted, high-capacity drug delivery system useful for the treatment of various pathological conditions.
摘要翻译： 本发明涉及药物递送领域。 更具体地，本发明涉及通过不稳定/非不稳定接头缀合的或直接与至少1,000种治疗性药物分子结合的噬菌体的制备和用途，使得药物分子与噬菌体的外表面缀合。 噬菌体任选地在其外壳上显示赋予其对靶细胞特异性的配体。 因此，提供了可用于治疗各种病理状况的靶向高容量药物递送系统。
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公开(公告)号：US07985573B2
公开(公告)日：2011-07-26
申请号：US11850942
申请日：2007-09-06
申请人： Iftach Yacoby , Eliora Z. Ron , Doron Shabat , Marina Shamis , Itai Benhar
发明人： Iftach Yacoby , Eliora Z. Ron , Doron Shabat , Marina Shamis , Itai Benhar
CPC分类号： A61K47/62
摘要： The present invention relates to the field of drug delivery. More specifically, the invention relates to the preparation and use of a bacteriophage conjugated through a labile/non labile linker or directly to at least 1,000 therapeutic drug molecules such that the drug molecules are conjugated to the outer surface of the bacteriophage. The bacteriophage optionally displays on its coat a ligand that endows it with specificity towards target cells. Thus, there is provided a targeted, high-capacity drug delivery system useful for the treatment of various pathological conditions.
摘要翻译： 本发明涉及药物递送领域。 更具体地，本发明涉及通过不稳定/非不稳定接头缀合的或直接与至少1,000种治疗性药物分子结合的噬菌体的制备和用途，使得药物分子与噬菌体的外表面缀合。 噬菌体任选地在其外壳上显示赋予其对靶细胞特异性的配体。 因此，提供了可用于治疗各种病理状况的靶向高容量药物递送系统。
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公开(公告)号：US20110286971A1
公开(公告)日：2011-11-24
申请号：US13159171
申请日：2011-06-13
申请人： Iftach YACOBY , Eliora Z. Ron , Doron Shabat , Marina Shamis , Itai Benhar
发明人： Iftach YACOBY , Eliora Z. Ron , Doron Shabat , Marina Shamis , Itai Benhar
IPC分类号： A61K35/76 , C12N7/01 , A61P31/10 , A61P37/06 , A61P31/12 , A61P33/00 , A61P9/10 , A61P35/00 , C12N7/00 , A61P31/04
CPC分类号： A61K47/62
摘要： The present invention relates to the field of drug delivery. More specifically, the invention relates to the preparation and use of a bacteriophage conjugated through a labile/non labile linker or directly to at least 1,000 therapeutic drug molecules such that the drug molecules are conjugated to the outer surface of the bacteriophage. The bacteriophage optionally displays on its coat a ligand that endows it with specificity towards target cells. Thus, there is provided a targeted, high-capacity drug delivery system useful for the treatment of various pathological conditions.
摘要翻译： 本发明涉及药物递送领域。 更具体地，本发明涉及通过不稳定/非不稳定接头缀合的或直接与至少1,000种治疗性药物分子结合的噬菌体的制备和用途，使得药物分子与噬菌体的外表面缀合。 噬菌体任选地在其外壳上显示赋予其对靶细胞特异性的配体。 因此，提供了可用于治疗各种病理状况的靶向高容量药物递送系统。
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4.发明申请Self-immolative dendrimers releasing many active moieties upon a single activating event 审中-公开自发性树枝状大分子在单一活化事件发生许多活性部分公开(公告)号：US20050271615A1
公开(公告)日：2005-12-08
申请号：US10525951
申请日：2003-08-28
申请人： Doron Shabat , Benjamin List , Roey Amir , Marina Shamis , Neta Pessah
发明人： Doron Shabat , Benjamin List , Roey Amir , Marina Shamis , Neta Pessah
IPC分类号： A61K31/785 , A61K47/48 , C08G83/00 , C08L77/06
CPC分类号： C08G83/003 , A61K47/6949 , B82Y5/00
摘要： A self-immolative dendrimer capable of releasing all of its tail units upon a single cleavage event, methods of synthesizing same and uses thereof are disclosed.
摘要翻译： 公开了能够在单次切割事件时释放其所有尾部单元的自褪色树枝状大分子，其合成方法及其用途。
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