公开(公告)号：US20220265715A1

公开(公告)日：2022-08-25

申请号：US17628118

申请日：2020-07-24

申请人： Eureka Therapeutics, Inc.

发明人： Hongruo YUN ,  Jun Cui ,  Pengbo Zhang ,  Yiyang Xu ,  Lucas Horan ,  Shaohua Xu ,  Guangyan Xiong ,  Shan LI ,  Yixiang Xu ,  Hong Liu

IPC分类号： A61K35/17 ,  A61P35/00 ,  C07K14/725 ,  C07K14/705

摘要： Described herein are chimeric antigen receptors (CARs) comprising an extracellular target-binding domain comprising an antibody moiety (e.g., a single chain variable fragment (scFv) antibody), a transmembrane domain, a CD30 costimulatory domain, and a primary signaling domain. Also provided herein are methods of using the same or compositions thereof for the therapeutic treatment of cancers (e.g., hematological cancers or solid tumor cancers).

公开(公告)号：US20220185910A1

公开(公告)日：2022-06-16

申请号：US17253589

申请日：2019-06-17

申请人： EUREKA THERAPEUTICS, INC.

发明人： Hong LIU ,  Hongruo YUN ,  Xiaomei GE ,  Zhiyuan YANG ,  Lianxing LIU ,  Pengbo ZHANG ,  Yixiang XU ,  Shan LI ,  Lucas HORAN

IPC分类号： C07K16/30 ,  C07K14/725 ,  C07K14/705 ,  G01N33/574 ,  C07K16/28 ,  A61P35/00

摘要： The present application provides constructs comprising an antibody moiety that specifically binds to PSMA (e.g., PSMA expressed on the surface of a cell). Also provided are methods of making and using these constructs.