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1.发明授权公开(公告)号：US11965021B2
公开(公告)日：2024-04-23
申请号：US16608366
申请日：2018-04-24
发明人： Hong Liu , Pengbo Zhang , Lucas Horan , Yiyang Xu , Binnaz K. Staley , Lianxing Liu , Hongruo Yun
IPC分类号： C07K14/705 , A61K35/17 , A61K39/00 , A61P35/00 , C07K14/725 , C07K16/28 , C07K16/30 , A61K38/00
CPC分类号： C07K16/2803 , A61K35/17 , A61P35/00 , C07K14/7051 , C07K14/70521 , C07K14/70578 , C07K16/2809 , C07K16/2827 , C07K16/283 , C07K16/2833 , C07K16/2887 , C07K16/303 , A61K38/00 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/522 , C07K2317/53 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/92 , C07K2317/94 , C07K2319/02 , C07K2319/03 , C07K2319/30 , C07K2319/33
摘要： The present application provides immune cells (such as T cells) comprising a chimeric antibody-T cell receptor (TCR) construct (caTCR) and a chimeric signaling receptor (CSR) construct. The caTCR comprises an antigen-binding module that specifically binds to a target antigen and a T cell receptor module (TCRM) capable of recruiting at least one TCR-associated signaling molecule, and the CSR comprises a ligand-binding domain that specifically binds to a target ligand and a co-stimulatory signaling domain capable of providing a stimulatory signal to the immune cell. Also provided are methods of making and using these cells.
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公开(公告)号：US11613573B2
公开(公告)日：2023-03-28
申请号：US16608336
申请日：2018-04-24
发明人： Lucas Horan , Yiyang Xu , Zhiyuan Yang , Hong Liu , Javier Morales , Lianxing Liu
IPC分类号： A61P35/00 , A61K35/17 , C07K14/725 , C07K14/705 , C07K16/28 , C07K16/30 , A61K38/00 , A61K39/00
摘要： The present application provides chimeric antibody-TCR constructs comprising an antigen-binding module that specifically binds to a target antigen and a T cell receptor module capable of recruiting at least one TCR-associated signaling molecule. Also provided are methods of making and using these constructs.
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公开(公告)号：US11993661B2
公开(公告)日：2024-05-28
申请号：US17253589
申请日：2019-06-17
发明人： Hong Liu , Hongruo Yun , Xiaomei Ge , Zhiyuan Yang , Lianxing Liu , Pengbo Zhang , Yixiang Xu , Shan Li , Lucas Horan
IPC分类号： C07K16/00 , A61P35/00 , C07H21/04 , C07K14/705 , C07K14/725 , C07K16/28 , C07K16/30 , C07K16/46 , C12N5/02 , C12N15/00 , G01N33/574
CPC分类号： C07K16/3069 , A61P35/00 , C07K14/7051 , C07K14/70521 , C07K16/2809 , G01N33/57434 , C07K2317/21 , C07K2317/31 , C07K2317/622 , C07K2319/02 , C07K2319/03
摘要： The present application provides constructs comprising an antibody moiety that specifically binds to PSMA (e.g., PSMA expressed on the surface of a cell). Also provided are methods of making and using these constructs.
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4.发明申请公开(公告)号：US20220323497A1
公开(公告)日：2022-10-13
申请号：US17628120
申请日：2020-07-24
发明人： Hongruo YUN , Jun Cui , Pengbo Zhang , Yiyang Xu , Lucas Horan , Shaohua Xu , Guangyan Xiong , Shan Li , Yixiang Xu , Bradley Austin Heller , Hongbing Zhang , Hong Liu
IPC分类号： A61K35/17 , C12N5/0783 , C12N15/62 , C12N15/86 , C07K14/725 , C07K14/705 , A61P35/00
摘要： Described herein are immune cells comprising: a chimeric antigen receptor (CAR) that comprises (i) an extracellular target-binding domain comprising an antibody moiety; (ii) a transmembrane domain; and (iii) a primary signaling domain, and a chimeric stimulating receptor (CSR) that comprises (i) a ligand-binding module that is capable of binding or interacting with a target ligand; (ii) a transmembrane domain; and (iii) a CD30 costimulatory domain, in which the CSR in the immune cells lacks a functional primary signaling domain. Also provided herein are methods of using the same or compositions thereof for therapeutic treatment of cancers (e.g., hematological cancers or solid tumor cancers).
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公开(公告)号：US10098951B2
公开(公告)日：2018-10-16
申请号：US15829793
申请日：2017-12-01
发明人： Jingwei Lu , Zhiyuan Yang , Cheng Liu , Hong Liu , Yiyang Xu , Su Yan , Vivien Wai-Fan Chan , Lucas Horan
IPC分类号： C07K16/00 , A61K39/395 , A61K35/17 , C12N15/62 , C07K14/725 , C07K16/28 , A61K38/00 , A61K39/00
摘要： The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.
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公开(公告)号：US11976105B2
公开(公告)日：2024-05-07
申请号：US17181913
申请日：2021-02-22
发明人： Jingwei Lu , Zhiyuan Yang , Cheng Liu , Hong Liu , Yiyang Xu , Su Yan , Vivien Wai-Fan Chan , Lucas Horan
IPC分类号： C07K14/725 , A61K35/17 , A61K38/00 , A61K39/00 , A61K39/395 , A61P35/00 , C07K16/28 , C12N15/62
CPC分类号： C07K14/7051 , A61K35/17 , A61K38/00 , A61K39/39558 , A61P35/00 , C07K16/2809 , C07K16/2833 , C12N15/62 , A61K2039/505 , C07K16/2803 , C07K2317/51 , C07K2317/515 , C07K2317/522 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/03 , C07K2319/33 , C07K2319/74
摘要： The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.
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公开(公告)号：US20220265715A1
公开(公告)日：2022-08-25
申请号：US17628118
申请日：2020-07-24
发明人： Hongruo YUN , Jun Cui , Pengbo Zhang , Yiyang Xu , Lucas Horan , Shaohua Xu , Guangyan Xiong , Shan LI , Yixiang Xu , Hong Liu
IPC分类号： A61K35/17 , A61P35/00 , C07K14/725 , C07K14/705
摘要： Described herein are chimeric antigen receptors (CARs) comprising an extracellular target-binding domain comprising an antibody moiety (e.g., a single chain variable fragment (scFv) antibody), a transmembrane domain, a CD30 costimulatory domain, and a primary signaling domain. Also provided herein are methods of using the same or compositions thereof for the therapeutic treatment of cancers (e.g., hematological cancers or solid tumor cancers).
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公开(公告)号：US10464988B2
公开(公告)日：2019-11-05
申请号：US16121475
申请日：2018-09-04
发明人： Jingwei Lu , Zhiyuan Yang , Cheng Liu , Hong Liu , Yiyang Xu , Su Yan , Vivien Wai-Fan Chan , Lucas Horan
IPC分类号： A61K35/17 , C07K14/725 , C12N15/62 , A61K38/00 , A61K39/395 , C07K16/28 , A61K39/00
摘要： The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.
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公开(公告)号：US11421013B2
公开(公告)日：2022-08-23
申请号：US15769724
申请日：2016-10-21
发明人： Jingwei Lu , Zhiyuan Yang , Cheng Liu , Hong Liu , Yiyang Xu , Su Yan , Vivien Wai-Fan Chan , Lucas Horan
IPC分类号： C07K14/725 , A61K35/17 , C12N15/62 , A61K38/00 , A61P35/00 , A61K39/395 , C07K16/28 , A61K39/00
摘要： The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.
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10.发明授权公开(公告)号：US10822413B2
公开(公告)日：2020-11-03
申请号：US16660515
申请日：2019-10-22
发明人： Hong Liu , Pengbo Zhang , Lucas Horan , Yiyang Xu , Binnaz K. Staley , Lianxing Liu , Hongruo Yun
IPC分类号： A61P35/00 , A61K35/17 , C07K14/725 , C07K14/705 , C07K16/28 , C07K16/30 , A61K38/00 , A61K39/00
摘要： The present application provides immune cells (such as T cells) comprising a chimeric antibody-T cell receptor (TCR) construct (caTCR) and a chimeric signaling receptor (CSR) construct. The caTCR comprises an antigen-binding module that specifically binds to a target antigen and a T cell receptor module (TCRM) capable of recruiting at least one TCR-associated signaling molecule, and the CSR comprises a ligand-binding domain that specifically binds to a target ligand and a co-stimulatory signaling domain capable of providing a stimulatory signal to the immune cell. Also provided are methods of making and using these cells.
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