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公开(公告)号：US20220265715A1
公开(公告)日：2022-08-25
申请号：US17628118
申请日：2020-07-24
发明人： Hongruo YUN , Jun Cui , Pengbo Zhang , Yiyang Xu , Lucas Horan , Shaohua Xu , Guangyan Xiong , Shan LI , Yixiang Xu , Hong Liu
IPC分类号： A61K35/17 , A61P35/00 , C07K14/725 , C07K14/705
摘要： Described herein are chimeric antigen receptors (CARs) comprising an extracellular target-binding domain comprising an antibody moiety (e.g., a single chain variable fragment (scFv) antibody), a transmembrane domain, a CD30 costimulatory domain, and a primary signaling domain. Also provided herein are methods of using the same or compositions thereof for the therapeutic treatment of cancers (e.g., hematological cancers or solid tumor cancers).
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公开(公告)号：US11827672B2
公开(公告)日：2023-11-28
申请号：US17043352
申请日：2019-03-29
发明人： Jun Cui , Pengbo Zhang , Yiyang Xu , Shan Li , Yixiang Xu , Guangyan Xiong , Hongruo Yun , Lianxing Liu , Xiaomei Ge , Shaohua Xu , Hong Liu , Javier Morales
IPC分类号： C07K16/28 , A61P35/00 , C07K14/725 , A61K39/00 , G01N33/574
CPC分类号： C07K16/2803 , A61P35/00 , C07K14/7051 , C07K16/2809 , G01N33/57492 , A61K2039/505 , C07K2317/31 , C07K2317/622 , C07K2319/02 , C07K2319/03 , G01N2333/70503
摘要： Described herein are antibodies (e.g., single chain variable fragment (scFv) antibodies) and constructs comprising antibody moieties that bind to the extracellular domain of CD22 or a portion thereof (e.g., SEQ ID NO: 205 or a portion thereof). Also provided herein are methods of using the same or compositions thereof for the therapeutic treatment of diseases characterized by CD22 expression, in particular, B-cell lymphomas and leukemias.
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3.发明申请公开(公告)号：US20220323497A1
公开(公告)日：2022-10-13
申请号：US17628120
申请日：2020-07-24
发明人： Hongruo YUN , Jun Cui , Pengbo Zhang , Yiyang Xu , Lucas Horan , Shaohua Xu , Guangyan Xiong , Shan Li , Yixiang Xu , Bradley Austin Heller , Hongbing Zhang , Hong Liu
IPC分类号： A61K35/17 , C12N5/0783 , C12N15/62 , C12N15/86 , C07K14/725 , C07K14/705 , A61P35/00
摘要： Described herein are immune cells comprising: a chimeric antigen receptor (CAR) that comprises (i) an extracellular target-binding domain comprising an antibody moiety; (ii) a transmembrane domain; and (iii) a primary signaling domain, and a chimeric stimulating receptor (CSR) that comprises (i) a ligand-binding module that is capable of binding or interacting with a target ligand; (ii) a transmembrane domain; and (iii) a CD30 costimulatory domain, in which the CSR in the immune cells lacks a functional primary signaling domain. Also provided herein are methods of using the same or compositions thereof for therapeutic treatment of cancers (e.g., hematological cancers or solid tumor cancers).
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公开(公告)号：US20220267420A1
公开(公告)日：2022-08-25
申请号：US16970332
申请日：2019-02-14
发明人： David A. SCHEINBERG , Cheng LIU , Zhiyuan YANG , Lianxing LIU , Shaohua Xu , Pei WANG , Yiyang XU
IPC分类号： C07K16/18 , C07K14/725 , C07K14/74 , C07K14/705 , C12N5/0783
摘要： Provided herein are compositions, kits, and methods for manufacturing cells for adoptive cell therapy comprising (a) an engineered receptor, vector encoding an engineered receptor, or engineered immune cell expressing such engineered receptor or comprising such vector; and (b) a Fox P3 targeting agent.
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公开(公告)号：US20210017280A1
公开(公告)日：2021-01-21
申请号：US17043352
申请日：2019-03-29
发明人： Jun CUI , Pengbo Zhang , Yiyang Xu , Shan Li , Yixiang Xu , Guangyan Xiong , Hongruo Yun , Lianxing Liu , Xiaomei Ge , Shaohua Xu , Hong Liu , Javier Morales
IPC分类号： C07K16/28 , C07K14/725 , G01N33/574 , A61P35/00
摘要： Described herein are antibodies (e.g., single chain variable fragment (scFv) antibodies) and constructs comprising antibody moieties that bind to the extracellular domain of CD22 or a portion thereof (e.g., SEQ ID NO: 205 or a portion thereof). Also provided herein are methods of using the same or compositions thereof for the therapeutic treatment of diseases characterized by CD22 expression, in particular, B-cell lymphomas and leukemias.
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