公开(公告)号：US20230201370A1

公开(公告)日：2023-06-29

申请号：US18057359

申请日：2022-11-21

申请人： Evox Therapeutics Ltd. ,  Oxford University Innovation Limited

发明人： Justin HEAN ,  Imre MAGER ,  Matthew WOOD ,  Samir EL ANDALOUSSI ,  Oscar WIKLANDER ,  Joel NORDIN

IPC分类号： A61K48/00 ,  A61K47/65 ,  A61K41/00 ,  A61K47/64 ,  A61K47/00 ,  A61K9/127

CPC分类号： A61K48/0008 ,  A61K47/65 ,  A61K41/0042 ,  A61K47/6425 ,  A61K47/00 ,  A61K9/127 ,  A61K48/005 ,  A61K48/0091

摘要： The present invention pertains to an inventive release mechanism for extracellular vesicle (EV)-mediated intracellular and intramembrane delivery of therapeutic polypeptides. More specifically, the invention relates to EVs comprising polypeptide constructs which comprise a therapeutic polypeptide releasably attached to an exosomal polypeptide. Furthermore, the present invention pertains to manufacturing methods, pharmaceutical compositions, medical uses and applications, and various other embodiments related to the inventive EVs.

公开(公告)号：US20190167810A1

公开(公告)日：2019-06-06

申请号：US16304580

申请日：2017-05-25

申请人： EVOX THERAPEUTICS LTD ,  OXFORD UNIVERSITY INNOVATION

发明人： Justin HEAN ,  Imre MAGER ,  Matthew WOOD ,  Samir EL ANDALOUSSI ,  Oscar WIKLANDER ,  Joel NORDIN

IPC分类号： A61K48/00 ,  A61K9/127

摘要： The present invention pertains to an inventive release mechanism for extracellular vesicle (EV)-mediated intracellular and intramembrane delivery of therapeutic polypeptides. More specifically, the invention relates to EVs comprising polypeptide constructs which comprise a therapeutic polypeptide releasably attached to an exosomal polypeptide. Furthermore, the present invention pertains to manufacturing methods, pharmaceutical compositions, medical uses and applications, and various other embodiments related to the inventive EVs.