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29 条记录 (耗时 0.02 秒)

    Cell nucleus-entering compositions
    1.
    发明申请
    Cell nucleus-entering compositions 审中-公开
    细胞核进入组合物

    公开(公告)号：US20060100156A1

    公开(公告)日：2006-05-11

    申请号：US11240636

    申请日：2005-10-03

    申请人： Ewald Hannappel ,  Thomas Huff ,  Allan Goldstein ,  David Crockford

    发明人： Ewald Hannappel ,  Thomas Huff ,  Allan Goldstein ,  David Crockford

    IPC分类号： A61K38/08 ,  C07K7/06

    CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K2319/09

    摘要： A pharmaceutically acceptable composition and method for entering a cell nucleus utilizes a cell nucleus-entering polypeptide including at least one of amino acid sequence LKKTET, amino acid sequence LKKTNT or amino acid sequence KSKLKK, or a conservative variant thereof, linked to a physiologically active agent having at least one of therapeutic or diagnostic application in the cell nucleus.

    摘要翻译： 用于进入细胞核的药学上可接受的组合物和方法利用细胞核进入多肽，其包括与生理活性剂连接的氨基酸序列LKKTET，氨基酸序列LKKTNT或氨基酸序列KSKLKK或其保守变体中的至少一种 具有在细胞核中的治疗或诊断应用中的至少一种。

    TREATMENT OF INFECTIONS AND OTHER DISORDERS
    3.
    发明申请
    TREATMENT OF INFECTIONS AND OTHER DISORDERS 审中-公开
    治疗感染和其他疾病

    公开(公告)号：US20080051348A1

    公开(公告)日：2008-02-28

    申请号：US11773168

    申请日：2007-07-03

    申请人： Allan Goldstein ,  Jack Finkelstein ,  David Crockford

    发明人： Allan Goldstein ,  Jack Finkelstein ,  David Crockford

    IPC分类号： A61K38/00 ,  A61P43/00

    CPC分类号： A61K38/2292

    摘要： A method of treatment for treating, inhibiting, reducing or at least partly preventing respiratory or pulmonary microbial infection or gastrointestinal disorder of tissue of a subject, includes administering to a subject an effective amount of a composition including a polypeptide including thymosin β4 (TB4), an isoform of TB4, an N-terminal variant of TB4, a C-terminal variant of TB4, LKKTET or a conservative variant thereof, LKKTNT or a conservative variant thereof, TB4 sulfoxide, TB4ala, Tβ9, Tβ10, Tβ11, Tβ12, Tβ13, Tβ14, Tβ15, gelsolin, vitamin D binding protein (DBP), profilin, cofilin, adsevertin, propomyosin, fincilin, depactin, Dnasel, vilin, fragmin, severin, capping protein, β-actinin, acumentin or a combination thereof, so as to inhibit the infection or disorder.

    摘要翻译： 用于治疗，抑制，减少或至少部分防止受试者组织的呼吸道或肺部微生物感染或胃肠道疾病的治疗方法包括向受试者施用有效量的包含多肽的组合物，包括胸腺素β4（TB4）， TB4的同种型，TB4的N末端变体，TB4的C末端变体，LKKTET或其保守变体，LKKTNT或其保守变体，TB4亚砜，TB4Δa，Tbeta9， Tbeta10，Tbeta11，Tbeta12，Tbeta13，Tbeta14，Tbeta15，凝溶胶蛋白，维生素D结合蛋白（DBP），profilin，cofilin，adsevertin，纯肌球蛋白，fincilin，depactin，Dnasel，vilin，fragmin，severin，封端蛋白，β-肌动蛋白， 或其组合，以抑制感染或病症。

    Apparatus and method for hanging supplemental sets of curtains
    4.
    发明授权
    Apparatus and method for hanging supplemental sets of curtains 失效
    悬挂辅助窗帘的装置和方法

    公开(公告)号：US07648111B2

    公开(公告)日：2010-01-19

    申请号：US10925062

    申请日：2004-08-24

    申请人： Allan Goldstein

    发明人： Allan Goldstein

    IPC分类号： A47H1/10 ,  E04G25/00

    CPC分类号： A47H1/102 ,  A47H1/022 ,  A47H1/142 ,  Y10T403/55

    摘要： An end of a curtain rod is provided with a hook for grasping a mounting tube extending transversely from a wall-mounted flange. The hook may be offset from the longitudinal axis of the curtain rod to permit two rods with similar offset hooks to the mounted end to end, in axial alignment, on a common mounting tube. Alternatively, one rod may be provided with a centrally mounted hook and the other rod with a claw having spaced hooks for receiving the single centrally mounted hook of an axially aligned rod therebetween. Each hook an claw may be mounted on a connector which can be fitted over the end of a segment of a tubular curtain rod, with or without an adapter, depending upon whether the segment is an inner segment or outer segment of a telescoping curtain rod.

    摘要翻译： 窗帘杆的端部设置有用于抓握从壁挂式凸缘横向延伸的安装管的钩。 钩子可以从窗帘杆的纵向轴线偏移，以允许具有类似偏移钩的两个杆在轴向对准的情况下安装在公共安装管上。 或者，一个杆可以设置有中心安装的钩，另一个杆具有爪，其具有间隔开的钩，用于容纳在它们之间的轴向对准杆的单个中心安装的钩。 每个钩爪可以安装在连接器上，连接器可以安装在具有或不具有适配器的管状窗帘杆的段的端部上，这取决于该段是伸缩式窗帘杆的内部段还是外部段。

    Treatment or prevention of damage due to radiation exposure
    9.
    发明申请
    Treatment or prevention of damage due to radiation exposure 审中-公开
    治疗或预防由辐射引起的损伤

    公开(公告)号：US20060246057A1

    公开(公告)日：2006-11-02

    申请号：US10564766

    申请日：2004-07-19

    申请人： Allan Goldstein

    发明人： Allan Goldstein

    IPC分类号： A61K39/395 ,  A61K48/00 ,  A61K38/08

    CPC分类号： A61K38/2292 ,  A61K45/06

    摘要： A method of treatment or prevention of damage due to ionizing radiation exposure involves administering to a subject in need of such treatment an effective amount of a composition containing 1) a compound including a radiation damage-inhibiting polypeptide containing amino acid sequence LKKTET (such as Thymosin β4), a conservative variant of LKKTET, an actin-sequestering agent, an anti-inflammatory agent; 2) an agent which stimulates production of the compound in the subject; 3) an agent which regulates the compound in the subject; or 4) an antagonist of the compound, so as to inhibit radiation damage in the subject.

    摘要翻译： 治疗或预防由于电离辐射暴露引起的损伤的方法涉及对需要这种治疗的受试者施用有效量的组合物，其含有1）包含含有氨基酸序列LKKTET（例如胸腺素的辐射损伤抑制多肽）的化合物 β4），LKKTET的保守变体，肌动蛋白螯合剂，抗炎剂; 2）刺激受试者中化合物生产的试剂; 3）调节受试者中化合物的药剂; 或4）化合物的拮抗剂，以便抑制受试者的辐射损伤。

    Mounts for parallel curtain rods with adjustable spacing
    10.
    发明授权
    Mounts for parallel curtain rods with adjustable spacing 失效
    用于可调间距的平行帘杆安装

    公开(公告)号：US6135403A

    公开(公告)日：2000-10-24

    申请号：US238010

    申请日：1999-01-26

    申请人： Allan Goldstein

    发明人： Allan Goldstein

    IPC分类号： A47H1/12 ,  A47H1/142 ,  A47H1/14

    CPC分类号： A47H1/12 ,  A47H1/142

    摘要： A mount for supporting the ends of parallel hung curtain rods has telescoping male and female members pivotally mounted on a base with a tensioning screw. Connectors for receiving the ends of the curtain rods are mounted on remote ends of the telescoping male and female members. The distance between the connectors and the angle of an axis intersecting the connectors can be adjusted by loosening the tensioning screw and then tightening it to fix the connectors and, hence, the curtain rods in a desired disposition.

    摘要翻译： 用于支撑平行悬挂幕杆的端部的安装件具有可伸缩的公和母构件，其可旋转地安装在具有张紧螺钉的基座上。 用于接收帘杆的端部的连接器安装在伸缩式阳和阴构件的远端上。 连接器之间的距离和与连接器相交的轴线的角度可以通过松开张紧螺丝然后拧紧以将连接器和因此的窗帘杆固定在所需的布置中来调节。