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1.发明申请Method of treating, preventing, inhibiting or reducing damage to cardiac tissue with thymosin beta 4 fragments 审中-公开用胸腺素β4片段治疗，预防，抑制或减少心脏组织损伤的方法公开(公告)号：US20070191275A1
公开(公告)日：2007-08-16
申请号：US11649889
申请日：2007-01-05
申请人： Ewald Hannappel , Thomas Huff , Allan Goldstein
发明人： Ewald Hannappel , Thomas Huff , Allan Goldstein
IPC分类号： A61K38/17
CPC分类号： A61K38/07 , A61K38/2292
摘要： A method of treatment for promoting regeneration or repair a damaged cardiovascular tissue, or for preventing damage to cardiovascular tissue, includes administering to the tissue a damage-treating or -preventing fragment of thymosin beta 4 (Tβ4), such as AcSDKP, or a stimulating agent that forms such a fragment of (Tβ4).
摘要翻译： 用于促进再生或修复受损的心血管组织或用于预防对心血管组织的损伤的治疗方法包括向组织施用胸腺素β4（Tbeta4）的损伤治疗或预防性片段，例如AcSDKP，或刺激 形成（Tbeta4）片段的试剂。
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公开(公告)号：US20080248993A1
公开(公告)日：2008-10-09
申请号：US11722979
申请日：2006-01-17
IPC分类号： A61K38/02
CPC分类号： C07K14/57581 , A61K38/00
摘要： A composition including an oxidized or superoxidized methionine-containing beta thymosin peptide, isoform thereof, fragment thereof, isolated R-enantiomer thereof or isolated S-enantiomer thereof, other than racemic thymosin beta 4 sulfoxide, or a modified beta thymosin peptide, isoform or fragment thereof with an amino acid substituent substituted for at least one methionine of an amino acid sequence of a normally methionine-containing beta thymosin peptide, isoform or fragment thereof, and method for forming same.
摘要翻译： 包含氧化或超氧化的含甲硫氨酸的β胸腺素肽，其同种型，其片段，其分离的R-对映异构体或其分离的S-对映异构体，除外消旋胸腺素β4亚砜，或经修饰的β胸腺素肽，同种型或片段 的氨基酸取代基取代至少一种含有正常甲硫氨酸的β-胸腺素肽，同种型或其片段的氨基酸序列的甲硫氨酸及其形成方法。
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公开(公告)号：US20060100156A1
公开(公告)日：2006-05-11
申请号：US11240636
申请日：2005-10-03
申请人： Ewald Hannappel , Thomas Huff , Allan Goldstein , David Crockford
发明人： Ewald Hannappel , Thomas Huff , Allan Goldstein , David Crockford
CPC分类号： C07K7/06 , A61K38/00 , C07K2319/09
摘要： A pharmaceutically acceptable composition and method for entering a cell nucleus utilizes a cell nucleus-entering polypeptide including at least one of amino acid sequence LKKTET, amino acid sequence LKKTNT or amino acid sequence KSKLKK, or a conservative variant thereof, linked to a physiologically active agent having at least one of therapeutic or diagnostic application in the cell nucleus.
摘要翻译： 用于进入细胞核的药学上可接受的组合物和方法利用细胞核进入多肽，其包括与生理活性剂连接的氨基酸序列LKKTET，氨基酸序列LKKTNT或氨基酸序列KSKLKK或其保守变体中的至少一种 具有在细胞核中的治疗或诊断应用中的至少一种。
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公开(公告)号：US20100215583A1
公开(公告)日：2010-08-26
申请号：US12632654
申请日：2009-12-07
CPC分类号： C07K7/06 , A61K38/00 , C07K2319/09
摘要： A pharmaceutically acceptable composition and method for entering a cell nucleus utilizes a cell nucleus-entering polypeptide including at least one of amino acid sequence LKKTET (SEQ ID NO: 1), amino acid sequence LKKTNT (SEQ ID NO: 2) or amino acid sequence KSKLKK (SEQ ID NO: 3), or a conservative variant thereof, linked to a physiologically active agent having at least one of therapeutic or diagnostic application in the cell nucleus.
摘要翻译： 用于进入细胞核的药学上可接受的组合物和方法利用细胞核进入的多肽，其包括氨基酸序列LKKTET（SEQ ID NO：1），氨基酸序列LKKTNT（SEQ ID NO：2）或氨基酸序列 与具有在细胞核中具有治疗或诊断应用的至少一种的生理活性剂连接的KSKLKK（SEQ ID NO：3）或其保守变体。
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公开(公告)号：US07638483B2
公开(公告)日：2009-12-29
申请号：US11240636
申请日：2005-10-03
摘要： A pharmaceutically acceptable composition and method for entering a cell nucleus utilizes a cell nucleus-entering polypeptide including at least one of amino acid sequence LKKTET (SEQ ID NO:1), amino acid sequence LKKTNT (SEQ ID NO:2) or amino acid sequence KSKLKK (SEQ ID NO:3), or a conservative variant thereof, linked to a physiologically active agent having at least one of therapeutic or diagnostic application in the cell nucleus.
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