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    WEARABLE HEMOPERFUSION DEVICE
    2.
    发明申请
    WEARABLE HEMOPERFUSION DEVICE 审中-公开

    公开(公告)号：US20200338256A1

    公开(公告)日：2020-10-29

    申请号：US16922190

    申请日：2020-07-07

    Applicant: Exthera Medical Corporation

    Inventor： Robert S. Ward ,  Keith R. McCrea

    IPC: A61M1/36 ,  B01D15/08

    Abstract: The present technology relates to methods and devices for the removal of toxins and pathogens from infected blood of patients. In particular, devices are designed to be portable, wearable, disposable and self-contained extracorporeal devices that can be easily assembled from a kit.

    METHOD FOR MODULATING ENDOTHELIAL GLYCOCALYX STRUCTURE
    3.
    发明申请
    METHOD FOR MODULATING ENDOTHELIAL GLYCOCALYX STRUCTURE 有权

    公开(公告)号：US20240366853A1

    公开(公告)日：2024-11-07

    申请号：US18774159

    申请日：2024-07-16

    Applicant: ExThera Medical Corporation

    Inventor： Robert S. Ward ,  Keith R. McCrea ,  Lakhmir (Mink) Chawla

    IPC: A61M1/36 ,  A61K31/726 ,  A61K31/727 ,  A61K31/728 ,  A61K31/737 ,  A61P7/00 ,  B01J20/24

    Abstract: The present invention provides methods and devices for augmenting impaired glycocalyx barrier function in a subject in need thereof by contacting a sample (e.g., blood) obtained from the subject with a glycocalyx-mimetic adsorption media. The adsorption media includes glycosaminoglycan structures and, optionally, proteoglycan core proteins, which are conducive to enhancing and/or restoring the impaired glycocalyx barrier function in a sample. The contacted sample is subsequently separated from the adsorption media, producing a treated sample that can be infused into the subject. Methods and devices for treating a patient suffering from a disease associated with glycocalyx barrier dysfunction are also provided herein.

    METHODS FOR REMOVING CYTOKINES FROM BLOOD WITH SURFACE IMMOBILIZED POLYSACCHARIDES
    5.
    发明申请
    METHODS FOR REMOVING CYTOKINES FROM BLOOD WITH SURFACE IMMOBILIZED POLYSACCHARIDES 审中-公开
    用表面固定化多糖从血液中去除细胞因子的方法

    公开(公告)号：US20160331886A1

    公开(公告)日：2016-11-17

    申请号：US15199737

    申请日：2016-06-30

    Applicant: EXTHERA MEDICAL CORPORATION

    Inventor： ROBERT S. WARD ,  Keith R. McCrea ,  Olle Larm ,  Lars Adolfsson

    IPC: A61M1/36 ,  A61M1/38

    CPC classification number: A61M1/362 ,  A61K31/60 ,  A61K31/722 ,  A61K31/727 ,  A61K31/728 ,  A61M1/3472 ,  A61M1/3496 ,  A61M1/36 ,  A61M1/3621 ,  A61M1/3673 ,  A61M1/3679 ,  A61M1/3687 ,  A61M1/38 ,  A61M2202/0057

    Abstract: The present invention is directed to a method for removing cytokines and/or pathogens from blood or blood serum (blood) by contacting the blood with a solid, essentially non micro-porous substrate which has been surface treated with heparin, heparan sulfate and/or other molecules or chemical groups (the adsorbent media or media) having a binding affinity for the cytokine or pathogen(s) to be removed (the adsorbates), and wherein the size of the interstitial channels within said media is balanced with the amount of media surface area and the surface concentration of binding sites on the media in order to provide adequate adsorptive capacity while also allowing relatively high flow rates of blood through the adsorbent media.

    Abstract translation: 本发明涉及通过使血液与已经用肝素，硫酸乙酰肝素和/或表面处理的固体，基本上非微孔的底物接触，从血液或血清（血液）中除去细胞因子和/或病原体的方法 对待除去的细胞因子或病原体（吸附物）具有结合亲和力的其它分子或化学基团（吸附介质或介质），并且其中所述介质中的间质通道的大小与介质的量平衡 表面积和培养基上结合位点的表面浓度，以提供足够的吸附能力，同时还允许血液通过吸附介质的相对较高的流速。

    Methods for diagnosing infectious diseases using adsorption media
    7.
    发明授权
    Methods for diagnosing infectious diseases using adsorption media 有权

    公开(公告)号：US11306346B2

    公开(公告)日：2022-04-19

    申请号：US16663836

    申请日：2019-10-25

    Applicant: ExThera Medical Corporation

    Inventor： Robert S. Ward ,  Keith R. McCrea

    IPC: C12Q1/24 ,  C12Q1/689 ,  C12Q1/70 ,  B01D15/38 ,  G01N33/569

    Abstract: The present invention provides an in vitro method for concentrating infectious pathogens found in a biological sample obtained from an individual who is suspected of being infected with the pathogens. Provided herein is also an in vitro method for reducing or eliminating blood cells from a sample obtained from an individual suspected to being infected with an infectious pathogen. The present invention also provides a method for diagnosing malaria and a method for determining if an individual is infected with a pathogen. Provided herein is also a concentrator and a kit for use with the methods.

    Method for treating drug intoxication
    8.
    发明授权
    Method for treating drug intoxication 有权

    公开(公告)号：US10786615B2

    公开(公告)日：2020-09-29

    申请号：US15446822

    申请日：2017-03-01

    Applicant: ExThera Medical Corporation

    Inventor： Robert S. Ward ,  Keith R. McCrea

    IPC: A61M1/36 ,  B01J20/286 ,  B01J20/26 ,  B01J20/32 ,  B01D15/38 ,  B01J20/24 ,  A61K35/14

    Abstract: Methods and devices are disclosed for the treatment of a subject suffering from drug intoxication by cleansing a contaminated sample from the subject with adsorption media. The adsorption media composition is selected for its antithrombogenic properties and for its ability to adhere to one or more drug targets to be reduced or eliminated. The media can further be held in a cartridge for use in extracorporeal treatments such as those of hemoperfusion. Contacting the contaminated sample from the subject with the absorption medium allows for the separation of a portion of the drug target from the sample, producing a cleansed sample that can be infused into the subject.

    Methods for removing cytokines from blood with surface immobilized polysaccharides
    9.
    发明授权
    Methods for removing cytokines from blood with surface immobilized polysaccharides 有权
    用表面固定多糖从血液中去除细胞因子的方法

    公开(公告)号：US09408962B2

    公开(公告)日：2016-08-09

    申请号：US14261390

    申请日：2014-04-24

    Applicant: EXTHERA MEDICAL CORPORATION

    Inventor： Robert S. Ward ,  Keith R. McCrea ,  Olle Larm ,  Lars Adolfsson

    IPC: A61M1/36 ,  A61M1/34 ,  A61K31/60 ,  A61K31/722 ,  A61K31/727 ,  A61K31/728 ,  A61M1/38

    CPC classification number: A61M1/362 ,  A61K31/60 ,  A61K31/722 ,  A61K31/727 ,  A61K31/728 ,  A61M1/3472 ,  A61M1/3496 ,  A61M1/36 ,  A61M1/3621 ,  A61M1/3673 ,  A61M1/3679 ,  A61M1/3687 ,  A61M1/38 ,  A61M2202/0057

    Abstract: The present invention is directed to a method for removing cytokines and/or pathogens from blood or blood serum (blood) by contacting the blood with a solid, essentially non microporous substrate which has been surface treated with heparin, heparan sulfate and/or other molecules or chemical groups (the adsorbent media or media) having a binding affinity for the cytokine or pathogen(s) to be removed (the adsorbates), and wherein the size of the interstitial channels within said media is balanced with the amount of media surface area and the surface concentration of binding sites on the media in order to provide adequate adsorptive capacity while also allowing relatively high flow rates of blood through the adsorbent media.

    Abstract translation: 本发明涉及通过使血液与已经用肝素，硫酸乙酰肝素和/或其他分子表面处理的固体，基本上非微孔的底物接触来从血液或血清（血液）中除去细胞因子和/或病原体的方法 或对要除去的细胞因子或病原体（被吸附物）具有结合亲和力的化学基团（吸附介质或介质），并且其中所述介质内的间质通道的尺寸与介质表面积的量平衡 以及培养基上结合位点的表面浓度，以便提供足够的吸附能力，同时还允许血液通过吸附介质的相对较高的流速。

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